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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    Acetildenafil Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • classified Research-chemical

    Aliases: Hongdenafil

    Research-chemical Supplement

    Summary dose.wiki TripSit

    Acetildenafil (a.k.a. Hongdenafil) is an unapproved research chemical often detected as an undeclared adulterant in "herbal" sexual-enhancement supplements. Pharmacologically it shows sub-micromolar PDE-5 inhibition comparable to sildenafil (IC50 ≈ 7.6 nM), with a slightly longer half-life (≈ 3–5 hours) and anecdotal reports of milder facial flushing.

    Dose Information dose.wiki TripSit

    ROA Light Common Strong Heavy
    Oral 5-15mg 15-30mg 30-40mg 40mg+
    Sublingual 5-15mg 15-30mg 30-40mg 40mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki TripSit

    ROA Onset Peak Offset After Effects Total
    Oral 30-60 min 1-2 hrs 3-5 hrs 6-24 min 3-7 hrs
    Sublingual 10-45 min 1-2 hrs 3-5 hrs 6-24 min 3-7 hrs

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track Acetildenafil there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "Acetildenafil (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    Acetildenafil
    Unit
    mg
    Description 
    Acetildenafil
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): light 5-15 · common 15-30 · strong 30-40 · heavy 40+
Sublingual dose (mg): threshold 2 · light 5-15 · common 15-30 · strong 30-40 · heavy 40+

Oral duration: onset 0.5-1h · peak 1-2h · offset 3-5h · total 3-7h · after-effects 6-24m
Sublingual duration: onset 10-45m · peak 1-2h · offset 3-5h · total 3-7h · after-effects 6-24m

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 22.5 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up varies by mechanism; therapeutic tolerance may develop over weeks of regular use
    Reset typically days to weeks after discontinuation

    Tolerance Decay

    Half tolerance 3d Baseline ~14d

    Clinically relevant tolerance is not expected with intermittent use, based on class experience with sildenafil/tadalafil used PRN. Regular daily use may reduce perceived efficacy due to psychological habituation rather than pharmacologic tolerance.

    Cross-Tolerances

    Other PDE‑5 inhibitors
    50%

    Effects dose.wiki

    Negative
    • Facial/upper-body flushing
    • Headache/pressure behind eyes
    Neutral
    • Improved ability to achieve/maintain erection
    • Increased penile firmness
    • Mild nasal congestion
    • Dyspepsia
    • Rare prolonged erection
    Positive
    • Warmth in extremities
    Acetildenafil's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 TripSit 📖 PsychonautWiki