Acetildenafil
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Encyclopedic
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- 3 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- classified Research-chemical
- 3 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- classified Research-chemical
Aliases: Hongdenafil
Summary
Acetildenafil (a.k.a. Hongdenafil) is an unapproved research chemical often detected as an undeclared adulterant in "herbal" sexual-enhancement supplements. Pharmacologically it shows sub-micromolar PDE-5 inhibition comparable to sildenafil (IC50 ≈ 7.6 nM), with a slightly longer half-life (≈ 3–5 hours) and anecdotal reports of milder facial flushing.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 5-15mg | 15-30mg | 30-40mg | 40mg+ |
| Sublingual | 5-15mg | 15-30mg | 30-40mg | 40mg+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 30-60 min | 1-2 hrs | 3-5 hrs | 3-7 hrs |
| Sublingual | 10-45 min | 1-2 hrs | 3-5 hrs | 3-7 hrs |
Tolerance
Tolerance Decay
Clinically relevant tolerance is not expected with intermittent use, based on class experience with sildenafil/tadalafil used PRN. Regular daily use may reduce perceived efficacy due to psychological habituation rather than pharmacologic tolerance.
Cross-Tolerances
Effects
- Facial/upper-body flushing
- Headache/pressure behind eyes
- Improved ability to achieve/maintain erection
- Increased penile firmness
- Mild nasal congestion
- Dyspepsia
- Rare prolonged erection
- Warmth in extremities
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