Summary
Acetildenafil (a.k.a. Hongdenafil) is an unapproved research chemical often detected as an undeclared adulterant in "herbal" sexual-enhancement supplements. Pharmacologically it shows sub-micromolar PDE-5 inhibition comparable to sildenafil (IC50 ≈ 7.6 nM), with a slightly longer half-life (≈ 3–5 hours) and anecdotal reports of milder facial flushing. Because it is metabolised mainly via CYP3A4, potent inhibitors can greatly increase its plasma concentration. Users report effective erectile support at 10–40 mg; however, some counterfeit tablets contain 80–120 mg, raising the risk of priapism, headache, and hypotension.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 5-15mg | 15-30mg | 30-40mg | 40mg+ |
| Sublingual | 5-15mg | 15-30mg | 30-40mg | 40mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|
| Oral | 30-60 min | 1-2 hrs | 3-5 hrs | 6-24 min | 180-0 min |
| Sublingual | 10-45 min | 1-2 hrs | 3-5 hrs | 6-24 min | 180-0 min |
Tolerance
Build-up
varies by mechanism; therapeutic tolerance may develop over weeks of regular use
Reset
typically days to weeks after discontinuation
Effects
Positive
Negative
- Facial/upper-body flushing
- Headache/pressure behind eyes
- Improved ability to achieve/maintain erection
- Increased penile firmness
- Mild nasal congestion
- Dyspepsia
- Rare prolonged erection
Positive
- Warmth in extremities
Negative