Acrylfentanyl
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- classified Tentative
- classified Research-chemical
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- classified Tentative
- classified Research-chemical
Aliases: Acryloylfentanyl, acryl-fentanyl
Summary
Potency approximately 3-5x morphine per microgram; microgram-scale errors are routinely fatal. Several case reports describe naloxone resistance; higher doses or continuous infusion may be required. The acrylamide moiety is electrophilic with theoretical mutagenic and carcinogenic risk.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 5-12.5ug | 12.5-25ug | 25-47.5ug | 47.5ug+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 15-30 min | 30-90 min | 1-3 hrs | 3-5 hrs |
| Insufflated | 1-5 min | 30-90 min | 1-3 hrs | 3-5 hrs |
| Intravenous | 1-2 min | 30-90 min | 1-3 hrs | 3-5 hrs |
| Inhaled | 1-5 min | 30-90 min | 1-3 hrs | 3-5 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong euphoria with moderate itching/nausea, mild pain relief, low sedation
Tolerance
Tolerance Decay
Rapid tolerance accrues with consecutive daily use; marked loss of tolerance occurs after several days’ abstinence, increasing overdose risk on return. Cross‑tolerance expected across µ‑agonists, but potency and kinetics vary substantially between analogues. Data primarily anecdotal and inferred from broader opioid literature; individual variability is high.
Cross-Tolerances
Effects
- Physical euphoria
- Analgesia
- Cough suppression
- Respiratory depression
- Nausea
- Dry Mouth
- Sedation
- Itchiness
- Pupil constriction
- Difficulty urinating
- Relaxant
- Euphoria
- Anxiety suppression
- Cognitive euphoria
- Mood lift
- Reduced anxiety
- Constipation
- Compulsive redosing
- Motor control loss
- Dizziness
- Physical autonomy
- Warmth
- Color enhancement
- Increased music appreciation
- Brightened colour
- Light sensitivity
- Appetite suppression
- Disinhibition
- Dehydration
- Dulled perception
- Drifting
Combinations
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