Acrylfentanyl
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 29 combo interactions documented
- classified Tentative
- classified Research-chemical
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 29 combo interactions documented
- classified Tentative
- classified Research-chemical
Aliases: Acryloylfentanyl, acryl-fentanyl
Summary
Potency approximately 3-5x morphine per microgram; microgram-scale errors are routinely fatal. Several case reports describe naloxone resistance; higher doses or continuous infusion may be required. The acrylamide moiety is electrophilic with theoretical mutagenic and carcinogenic risk.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 5-12.5ug | 12.5-25ug | 25-47.5ug | 47.5ug+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 15-30 min | 30-90 min | 1-3 hrs | 3-5 hrs |
| Insufflated | 1-5 min | 30-90 min | 1-3 hrs | 3-5 hrs |
| Intravenous | 1-2 min | 30-90 min | 1-3 hrs | 3-5 hrs |
| Inhaled | 1-5 min | 30-90 min | 1-3 hrs | 3-5 hrs |
Effect Profile
Scores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong euphoria with moderate itching/nausea, mild pain relief, low sedation
Tolerance
No tolerance chart. Our decay curves for opioids were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.
Opioid tolerance drops fast when you stop, and even a few days off can be enough, so a dose that used to be normal can now stop your breathing. Overdose deaths rise sharply after prison, detox or leaving treatment, and tolerance also falls during a hospital stay. After any break, start with a much smaller amount, try a test dose first, don't use alone, and keep naloxone within reach. Alcohol, benzodiazepines, gabapentinoids and other sedatives make an opioid overdose much more likely.
Sources: FRANK: heroin · National Harm Reduction Coalition · WHO: opioid overdose · Merrall et al. 2010 · Binswanger et al. 2007 · Strang et al. 2003 · FDA 2019: gabapentinoids and breathing
Cross-Tolerances
Effects
Effect glossary — · full glossary
Combinations
Cross-Check Acrylfentanyl with another substanceHelpful Links
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Acrylfentanyl there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Acrylfentanyl Source: SubstanceSearch (substancesearch.com) Oral dose (µg): light 5-12.5ug · common 12.5-25ug · strong 25-47.5ug · heavy 47.5ug+ Oral duration: onset 15-30m · peak 0.5-1.5h · offset 1-3h · total 3-5h · after-effects 6-24h Insufflated duration: onset 1-5m · peak 0.5-1.5h · offset 1-3h · total 3-5h · after-effects 6-24h Intravenous duration: onset 1-2m · peak 0.5-1.5h · offset 1-3h · total 3-5h · after-effects 6-24h Inhaled duration: onset 1-5m · peak 0.5-1.5h · offset 1-3h · total 3-5h · after-effects 6-24h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 18.75 µg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for Acrylfentanyl? Let us know. Reports are reviewed by moderators — this is not posted publicly.