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    Disclaimer
    ☠ This is a fentanyl analogue active in microgram doses. Accidental overdose can be rapidly fatal. Naloxone should always be on hand.
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    Acrylfentanyl

    Aliases: Acryloylfentanyl, acryl-fentanyl

    Depressant Research-chemical Opioid

    Summary TheDrug.Wiki TripSit

    Potency approximately 3-5x morphine per microgram; microgram-scale errors are routinely fatal. Several case reports describe naloxone resistance; higher doses or continuous infusion may be required. The acrylamide moiety is electrophilic with theoretical mutagenic and carcinogenic risk.

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Oral 5-12.5ug 12.5-25ug 25-47.5ug 47.5ug+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Peak Offset After Effects Total
    Oral 15-30 min 30-90 min 1-3 hrs 6-24 hrs 1.8-5 hrs
    Insufflated 1-5 min 30-90 min 1-3 hrs 6-24 hrs 1.5-4.6 hrs
    Intravenous 1-2 min 30-90 min 1-3 hrs 6-24 hrs 1.5-4.5 hrs
    Inhaled 1-5 min 30-90 min 1-3 hrs 6-24 hrs 1.5-4.6 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 6.3
    Strong 6/10

    Strong euphoria with moderate itching/nausea, mild pain relief, low sedation

    Euphoria / Warmth ×3
    10
    physical euphoria euphoria cognitive euphoria warmth mood lift
    Analgesia ×2
    4
    analgesia
    Sedation / Relaxation ×1
    3
    sedation
    ⚠ Itching / Nausea ×1
    7
    nausea constipation dry mouth
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Acrylfentanyl
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Cross-Tolerances

    All µ-opioid agonists
    100%

    Effects TheDrug.Wiki TripSit

    Positive
    • Physical euphoria
    • Analgesia
    • Cough suppression
    Negative
    • Respiratory depression
    • Nausea
    • Dry Mouth
    Neutral
    • Sedation
    • Itchiness
    • Pupil constriction
    • Difficulty urinating
    • Relaxant
    Positive
    • Euphoria
    • Anxiety suppression
    • Cognitive euphoria
    • Mood lift
    • Reduced anxiety
    Negative
    • Constipation
    • Compulsive redosing
    • Motor control loss
    • Dizziness
    Neutral
    • Physical autonomy
    Positive
    • Warmth
    • Color enhancement
    • Increased music appreciation
    • Brightened colour
    Negative
    • Light sensitivity
    • Appetite suppression
    • Disinhibition
    • Dehydration
    Neutral
    • Dulled perception
    • Drifting

    Combinations TripSit

    Acrylfentanyl's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 TripSit 📖 PsychonautWiki