Acrylfentanyl
Aliases: Acryloylfentanyl, acryl-fentanyl
Categories
Summary
Potency approximately 3-5x morphine per microgram; microgram-scale errors are routinely fatal. Several case reports describe naloxone resistance; higher doses or continuous infusion may be required. The acrylamide moiety is electrophilic with theoretical mutagenic and carcinogenic risk. Reported elimination half-life in whole blood approximately 5-7 hours; subjective effects are shorter than systemic presence, creating a redose and over-accumulation hazard. Severe, idiosyncratic withdrawal has been noted even in poly-opioid users.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 5-12.5ug | 12.5-25ug | 25-47.5ug | 47.5ug+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|
| Oral | 15-30 min | 30-90 min | 1-3 hrs | 6-24 hrs | 180-0 min |
| Insufflated | 1-5 min | 30-90 min | 1-3 hrs | 6-24 hrs | 180-0 min |
| Intravenous | 1-2 min | 30-90 min | 1-3 hrs | 6-24 hrs | 180-0 min |
| Inhaled | 1-5 min | 30-90 min | 1-3 hrs | 6-24 hrs | 180-0 min |
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Effects
Positive
- Physical euphoria
- Analgesia
- Cough suppression
Negative
- Respiratory depression
- Nausea
- Dry Mouth
- Sedation
- Itchiness
- Pupil constriction
- Difficulty urinating
- Relaxant
Positive
- Euphoria
- Anxiety suppression
- Cognitive euphoria
- Mood lift
- Reduced anxiety
Negative
- Constipation
- Compulsive redosing
- Motor control loss
- Dizziness
- Physical autonomy
Positive
- Warmth
- Color enhancement
- Increased music appreciation
- Brightened colour
Negative
- Light sensitivity
- Appetite suppression
- Disinhibition
- Dehydration
- Dulled perception
- Drifting