Summary
Adamantanes are a chemical class of organic compounds that are based on the adamantane structure. Members of this class have various pharmacological actions which includes dopaminergic stimulation and NMDA receptor antagonism. Memantine and bromantane are two prominent members of this class.
Tolerance
Build-up
develops with repeated use over days to weeks
Reset
2–4 weeks for noticeable reduction
Effects
Positive
- Stimulation
- Physical euphoria
- Pain relief
- Analgesia
Negative
- Numbness
- Loss of balance
- Nausea
- Increased heart rate
- Sedation
- Physical disconnection
Positive
- Cognitive euphoria
- Conceptual thinking
Negative
- Depersonalization
- Motor control loss
- Derealization
- Memory suppression
- Amnesia
- Dizziness
- Disconnection
- Time distortion
Positive
- Increased music appreciation
- Perception of bodily lightness
Negative
- Derealization
- Tactile suppression
- Disinhibition
- Spatial disorientation
- Double vision
- Auditory distortion
- Visual disconnection
- Scenery slicing