Summary
ADB-PINACA is a positional isomer of Schedule I synthetic cannabinoids; potency at CB1 is in the sub-nanomolar range (EC50 = 0.52 nM), approximately 3-6 times more potent than THC. Extremely narrow safety margin – milligram-scale errors have produced seizures, severe tachycardia, and fatalities. Always weigh with a 0.001 g (1 mg) readability scale and apply evenly to an inert herbal carrier; avoid 'eye-balling' liquid drops. Significant number of hospitalizations (Colorado 2013 outbreak, CDC) and several confirmed deaths have been attributed to ADB-PINACA or its isomers. Metabolized primarily via hepatic CYP3A4/2C9; inhibitors (ketoconazole, fluconazole, grapefruit) may prolong and intensify effects.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Smoked | 0.5-1mg | - | - | - |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects |
|---|---|---|---|---|
| Smoked | 1-2 min | 5-30 min | 1-2 hrs | 6-24 hrs |
| Oral | 15-45 min | 30-90 min | 2-3 hrs | 6-24 hrs |
Tolerance
Build-up
develops over weeks of regular use via CB1 receptor downregulation
Reset
2–4 weeks for most users; heavy users may need longer
Effects
Positive
- Pain relief
Negative
- Rapid intoxication and body load
- Dry mouth and red eyes
- Tachycardia and palpitations
- Nausea/vomiting
- Seizure activity in vulnerable users
- Nausea
- Body heaviness and motor incoordination
- Cataleptic episodes at high doses
- Spontaneous bodily sensations
Positive
- Introspection
- Euphoria
Negative
- Short-term memory impairment
- Anxiety
- Paranoia
- Motor control loss
- Short-term memory suppression
- Intense euphoria or dysphoria
- Altered time perception
- Time distortion
Positive
- Color enhancement
- Appetite enhancement
- Perception of bodily lightness
- Increased Music Appreciation
- Bodily control enhancement
Negative
- Dehydration
- Auditory and visual distortions
- Visual distortions
- Appetite intensification
- Changes in felt gravity