ADB-PINACA
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 1 source
- 2 ROAs with full dose ladders
- duration data present
- 16 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 1 source
- 2 ROAs with full dose ladders
- duration data present
- 16 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: Isomer 1
Summary
ADB-PINACA is a synthetic cannabinoid (an indazolecarboxamide research chemical) and a positional isomer of Schedule I synthetic cannabinoids. It acts at the CB1 receptor with sub-nanomolar potency (EC50 = 0.52 nM), making it approximately 3-6 times more potent than THC. This high potency leaves an extremely narrow safety margin, and milligram-scale dosing errors have produced seizures, severe tachycardia, and fatalities. Because of this, it should be weighed with a 0.001 g (1 mg) readability scale and applied evenly to an inert herbal carrier rather than "eye-balled" as liquid drops.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Smoked | 0.5-1mg | 1-2mg | 2-4mg | 4mg+ |
| Oral | 1-2mg | 2-3mg | 3-5mg | 5mg+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Smoked | - | 5-30 min | 1-2 hrs | 1-3 hrs |
| Oral | 15-45 min | 5-30 min | 1-2 hrs | 1-3 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Low visuals, headspace, and body load
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session โ the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Frequent SCRA administration leads to rapid tolerance build-up and withdrawal (irritability, insomnia, sweats, nausea) described widely in community reports. Decay appears partial over 1โ2 weeks with further recovery by ~4 weeks in many users; exact kinetics are not established.
Cross-Tolerances
Effects
- Pain relief
- Rapid intoxication and body load
- Dry mouth and red eyes
- Tachycardia and palpitations
- Nausea/vomiting
- Seizure activity in vulnerable users
- Nausea
- Body heaviness and motor incoordination
- Cataleptic episodes at high doses
- Spontaneous bodily sensations
- Introspection
- Euphoria
- Short-term memory impairment
- Anxiety
- Paranoia
- Motor control loss
- Short-term memory suppression
- Intense euphoria or dysphoria
- Altered time perception
- Time distortion
- Color enhancement
- Appetite enhancement
- Perception of bodily lightness
- Increased Music Appreciation
- Bodily control enhancement
- Dehydration
- Auditory and visual distortions
- Visual distortions
- Appetite intensification
- Changes in felt gravity
Combinations
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