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    ADB-PINACA isomer 1 Well-documented
    Well-documented
    Multiple authoritative sources agree on dosing and effects.
    • 2 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 27 combo interactions documented

    Cannabinoid

    Summary

    ADB-PINACA isomer 1 is a synthetic cannabinoid. Reported effects include euphoria, visual distortions, color enhancement, and anxiety suppression. Limited data is available on its dosage and safety profile.

    Dose Information Drugs.Wiki

    Dose basis. Smoked: Doses are aggregated from community reports and case data; potency between batches varies markedly. Because milligram-level errors can cause overdose, volumetric solutions (e.g., 1–2 mg/mL in ethanol/acetone) applied evenly to inert herb and thoroughly dried are preferred over sprinkling dry powder. Avoid “eyeballing” or drop-counting. Source quality is highly variable in “Spice/K2”-type products. Oral: Oral effects are slower, longer, and harder to titrate. Start low due to delayed onset and risk of stacking. Many severe SCRA poisonings occur with mislabeled commercial products; treat any unknown edible/vape as potentially overdosed. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Smoked 0.5-1mg 1-2mg 2-4mg 4mg+
    Oral 1-2mg 2-3mg 3-5mg 5mg+
    Light Common Strong Heavy
    Sources

    Smoked

    Dose ladder — Drugs.Wiki

    Oral

    Dose ladder — Drugs.Wiki

    Onset, Duration & After-effects Drugs.Wiki

    ROA Onset Peak Offset After Effects Total
    Smoked <1-2 min 5-30 min 1-2 hrs 6-24 hrs 1-3 hrs
    Oral 15-45 min 30-90 min 2-3 hrs 6-24 hrs 1-3 hrs

    Tolerance

    Build-up develops over weeks of regular use via CB1 receptor downregulation
    Reset 2–4 weeks for most users; heavy users may need longer

    Tolerance Decay

    Full tolerance 3d Half tolerance 21d Baseline ~28d

    Effects

    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral

    Combinations

    Cross-Check ADB-PINACA isomer 1 with another substance

    ADB-PINACA isomer 1's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track ADB-PINACA isomer 1 there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "ADB-PINACA isomer 1 (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    ADB-PINACA isomer 1
    Unit
    mg
    Description 
    ADB-PINACA isomer 1
Source: SubstanceSearch (substancesearch.com)

Smoked dose (mg): threshold 0.5 · light 0.5-1 · common 1-2 · strong 2-4 · heavy 4+
Oral dose (mg): threshold 1 · light 1-2 · common 2-3 · strong 3-5 · heavy 5+

Smoked duration: onset <1-2m · peak 5-30m · offset 1-2h · total 1-3h · after-effects 6-24h
Oral duration: onset 15-45m · peak 0.5-1.5h · offset 2-3h · total 1-3h · after-effects 6-24h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 1.5 mg (Smoked).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.