AEM
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 1 source
- descriptive-only dose data
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 1 source
- descriptive-only dose data
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: Ξ±-ethylmescaline, Ξ±-ethyl-3,4,5-trimethoxyphenethylamine
Summary
AEM is an extremely rare and poorly documented phenethylamine psychedelic first synthesized by Alexander Shulgin and described in PiHKAL as entry #1. Shulgin reported that doses exceeding 220 mg produced few to no psychoactive effects, classifying it as essentially inactive. The compound's inactivity discouraged Shulgin from synthesizing further alpha-position-extended mescaline analogues (such as alpha-propylmescaline or alpha-butylmescaline).
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | Unknown (inactive) | - | - | - |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Low visuals and headspace
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track AEM there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
AEM Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 220+ (inactive) Β· light Unknown (inactive) Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
No established activity; tolerance patterns cannot be inferred for AEM itself. If the ingested material is actually an active serotonergic psychedelic, expect typical crossβtolerance with other psychedelics lasting days to weeks.
Effects
- Dilated pupils
- Introspection
- No significant psychoactive effects reported
- Color enhancement
- Visual distortions
Combinations
Cross-Check AEM with another substancePiHKAL / TiHKAL
Helpful Links
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