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    Allylescaline molecular structure

    Allylescaline Stats & Data

    Al Allylmescaline
    NPS DataHub
    MW237.3
    FormulaC13H19NO3
    CAS39201-75-7
    IUPAC2-(3,5-dimethoxy-4-prop-2-enoxyphenyl)ethanamine
    SMILESNCCc1cc(OC)c(OCC=C)c(OC)c1
    InChIKeyJNUAYHHGCXYBHX-UHFFFAOYSA-N
    Phenethylamines; 2020/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2021/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2022/1. Von 2-Phenethylamin abgeleitete Verbindungen
    Chemical Class Phenethylamine
    Psychoactive Class Psychedelic

    Pharmacology

    DrugBank
    State Solid

    Description

    A metallic element that has the atomic number 13, atomic symbol Al, and atomic weight 26.98.

    Mechanism of Action

    Aluminum Acetate is an astringent. An astrignent is a chemical that tends to shrink or constrict body tissues, usually locally after topical medicinal application. The shrinkage or constriction is through osmotic flow of water (or other fluids) away from the area where the astringent was applied. Astringent medicines cause shrinkage of mucous membranes or exposed tissues and are often used internally to check discharge of blood serum or mucous secretions. This can happen with a sore throat, hemorrhages, diarrhea, or with peptic ulcers. Externally applied astringents, which cause mild coagulation of skin proteins, dry, harden, and protect the skin. Acne sufferers are often advised to use astringents if they have oily skin. Astringents also help heal stretch marks and other scars. Mild astringent solutions are used in the relief of such minor skin irritations as those resulting from superficial cuts, allergies, insect bites, or fungal infections such as athlete's foot.

    Receptor Profile

    Receptor Actions

    Agonists
    5-HT2A receptor agonist (partial)
    5-HT2B receptor agonist (partial)
    5-HT2C receptor agonist (partial)

    History & Culture

    Allylescaline was first documented in the scientific literature by Czech chemist Otakar Leminger in 1972. The compound received broader attention when American chemist Alexander Shulgin synthesized and characterized its psychoactive effects, publishing his findings in the 1991 book PiHKAL: A Chemical Love Story. In PiHKAL, Shulgin described allylescaline's subjective effects and established dosage parameters based on his bioassay methodology. The compound remained relatively obscure for over two decades following PiHKAL's publication. It emerged on the research chemical market in 2013, when it was identified as a novel designer drug being sold online. This appearance prompted regulatory responses in several countries during the mid-2010s.

    Effect Profile

    Curated + 20 Reports
    Psychedelic 8.8

    Strong visuals, headspace, auditory effects, and body load

    Visual Intensity×3
    1010
    Headspace Depth×3
    107.5
    Auditory Effects×1
    1010
    Body Load / Somatic Effects×1
    1010
    Catalog Erowid

    Tolerance & Pharmacokinetics

    drugs.wiki

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Experience Report Analysis

    Erowid
    20 Reports
    2012–2023 Date Range
    18 With Age Data
    23 Effects Detected

    Demographics

    Gender Distribution

    Age Distribution

    Reports Over Time

    Effect Analysis

    Erowid

    Effects aggregated from 20 experience reports (20 Erowid)

    20 Reports
    23 Effects Detected
    9 Positive
    7 Adverse
    7 Neutral

    Effect Sentiment Distribution

    Confidence Distribution

    Positive Effects 9

    Color Enhancement 70.0% 70%
    Stimulation 55.0% 70%
    Euphoria 45.0% 70%
    Focus Enhancement 40.0% 70%
    Body High 35.0% 70%
    Music Enhancement 35.0% 70%
    Tactile Enhancement 35.0% 70%
    Introspection 30.0% 70%
    Empathy 30.0% 70%

    Adverse Effects 7

    Anxiety 60.0% 70%
    Nausea 55.0% 70%
    Headache 25.0% 70%
    Muscle Tension 25.0% 70%
    Motor Impairment 15.0% 70%
    Confusion 15.0% 70%
    Increased Heart Rate 15.0% 70%

    Dosage Distribution

    Dose distribution from experience reports

    Median: 27.0 mg IQR: 15.0–50.0 mg n=15

    Real-World Dose Distribution

    62K Doses

    From 33 individual dose entries

    Oral (n=30)

    Median: 15.0mg 25th: 10.0mg 75th: 25.0mg 90th: 41.0mg
    mg/kg median: 0.208 mg/kg 75th: 0.351

    Form / Preparation

    Most common forms and preparations reported

    Body-Weight Dosing

    Dose relative to body weight from reports with weight data

    Median: 0.344 mg/kg IQR: 0.157–0.588 mg/kg n=15

    Redose Patterns

    Redosing behavior across 15 reports

    26.7% Redosed
    1.6 Avg Doses
    70m Median Interval

    Legal Status

    Country Status Notes
    Germany Anlage I BtMG Controlled under the Narcotics Act (Betäubungsmittelgesetz) Schedule I since February 1, 1997, listed as '4-Allyloxy-3,5-dimethoxy-phenethylazan'. Manufacturing, possession, import, export, purchase, sale, procurement, and dispensation without a license are prohibited.
    Japan Controlled substance Designated as a controlled substance effective March 25, 2015.
    Sweden Illegal Classified as an illegal substance since January 2016.
    Switzerland Controlled (Verzeichnis E) Specifically named and controlled under Verzeichnis E of Swiss narcotics legislation.
    United Kingdom Illegal (Psychoactive Substances Act) Production, supply, and import prohibited under the Psychoactive Substances Act 2016, which came into effect on May 26, 2016.
    United States Unscheduled Not directly scheduled under the Controlled Substances Act. However, due to structural similarities with mescaline, sale for human consumption or use for illicit purposes could potentially be prosecuted under the Federal Analogue Act.
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