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    AM-1248 molecular structure

    AM-1248 Stats & Data

    Psychedelic Research-chemical Cannabinoid
    PubChem CID 10293794
    NPS DataHub
    MW390.57
    FormulaC26H34N2O
    CAS335160-66-2
    IUPAC1-[(N-methylpiperidin-2-yl)methyl]-3-(adamant-1-oyl)indole
    SMILESCN1CCCCC1Cn1cc(C(=O)C23CC4CC(CC(C4)C2)C3)c2ccccc12
    InChIKeyJRECAXBHMULNJQ-UHFFFAOYSA-N
    2020/2.1 Von Indol Pyrazol und 4-Chinolon abgeleitete Verbindungen; 2021/2.1 Von Indol Pyrazol und 4-Chinolon abgeleitete Verbindungen; 2022/2.1 Von Indol Pyrazol und 4-Chinolon abgeleitete Verbindungen
    Chemical Class Cannabinoid
    Psychoactive Class Psychedelic
    Half-Life Unknown in humans; effects are short‑lived when inhaled, suggesting rapid distribution/elimination; detection and PK data for AM‑1248 specifically are scarce in open literature.

    Pharmacology

    DrugBank

    Effect Profile

    Curated
    Psychedelic 5.6

    Strong visuals with mild body load, headspace, and auditory effects

    Visual Intensity×3
    8
    Headspace Depth×3
    4
    Auditory Effects×1
    4
    Body Load / Somatic Effects×1
    5
    Based on reports from:
    Erowid Experience Reports PsychonautWiki AM-1248

    Tolerance & Pharmacokinetics

    drugs.wiki
    Half-Life
    Unknown in humans; effects are short‑lived when inhaled, suggesting rapid distribution/elimination; detection and PK data for AM‑1248 specifically are scarce in open literature.
    Addiction Potential
    Moderate to high. Synthetic cannabinoids show rapid tolerance development and a recognized withdrawal syndrome (sleep disturbance, irritability, anxiety, nausea; occasionally seizures), particularly with daily/frequent use.

    Tolerance Decay

    Full tolerance 3d Half tolerance 14d Baseline ~28d

    Tolerance and cross‑tolerance patterns are inferred from user surveys and clinical observations of SCRAs as a class; quantitative values are illustrative to help plan spacing between sessions and should not be treated as precise pharmacometrics.

    Cross-Tolerances

    Cannabis (THC)
    50% ●○○
    Other synthetic cannabinoids
    70% ●○○

    Harm Reduction

    drugs.wiki

    Evidence-backed harm-reduction points and rationale added below in this message. See citations. Ki/affinity values for AM‑1248 vary by source; secondary compilations suggest nanomolar CB binding with CB2 > CB1 selectivity, but primary in vitro data are limited in open sources accessible here. Treat potency as very high and batch-variable.

    References

    Drugs.wiki References

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