Summary
AM-1248 is an extremely potent full agonist at CB1 and CB2 receptors with binding affinities approximately 1000-fold higher than THC. Effects are qualitatively similar to very strong cannabis concentrates but arrive faster and without the self-titration possible when smoking plant material. Users report a steep dose-response curve where accidentally doubling a planned dose can turn a mild experience into overwhelming dysphoria, panic, or unconsciousness. Powder is usually applied to herbal carrier; uneven distribution creates dangerous "hot spots." Emergency presentations have included severe agitation, seizures, and acute kidney injury. No specific antagonists exist; supportive care is recommended.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects |
|---|---|---|---|---|
| Vaporized | 1 min | 5-30 min | 30-60 min | 2-6 hrs |
| Oral | 30-90 min | 1-3 hrs | 1-2 hrs | 2-6 hrs |
Tolerance
Build-up
develops over weeks of regular use via CB1 receptor downregulation
Reset
2–4 weeks for most users; heavy users may need longer
Effects
Positive
- Bodily warmth
- Stimulation
- Physical euphoria
Negative
- Tachycardia
- Nausea
- Increased heart rate
- Pupil dilation
- Insomnia
- Xerostomia
- Sedation
Positive
- Euphoria
- Anxiety suppression
- Conceptual thinking
- Analysis enhancement
- Empathy
Negative
- Anxiety
- Memory suppression
- Confusion
- Motor control loss
- Time distortion
Positive
- Tactile enhancement
- Color enhancement
- Tracers
- Increased music appreciation
- Enhanced tactile sensation
- Pattern recognition enhancement
Negative
- Visual snow
- Visual distortions
- Drifting
- Auditory distortion