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    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Synthetic cannabinoids are far more potent and unpredictable than natural cannabis. They lack a ceiling effect and have been linked to seizures, psychosis, and death.

    AM-1248 Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 16 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Psychedelic Research-chemical Cannabinoid

    Summary dose.wiki

    AM-1248 is an extremely potent full agonist at CB1 and CB2 receptors with binding affinities approximately 1000-fold higher than THC. Effects are qualitatively similar to very strong cannabis concentrates but arrive faster and without the self-titration possible when smoking plant material. Users report a steep dose-response curve where accidentally doubling a planned dose can turn a mild experience into overwhelming dysphoria, panic, or unconsciousness.

    Dose Information dose.wiki Drugs.Wiki

    Dose basis. Doses are derived from user reports and vary widely by batch potency and coating; never eyeball. Always weigh with a 0.001 g (1 mg) scale. To prepare smoking material, people commonly dissolve a precisely weighed amount in high-purity ethanol or acetone, apply evenly to a pre-weighed herbal substrate, allow to fully evaporate, and mix thoroughly to reduce ‘hot spots.’ Potency between vendors and batches can differ by multiples. Start at the very low end and wait for full effects before redosing. Oral onset is delayed and variable; stacking before the first dose peaks is a common cause of accidental overdose. User-derived estimates only; potency varies markedly. Mix into oil/fat for more reliable absorption; avoid redosing for at least 2 hours. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Vaporized 0.3-1mg 1-3mg 3-5mg 5mg+
    Oral 1-3mg 3-6mg 6-10mg 10mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Peak Offset After Effects Total
    Vaporized 36 sec 5-30 min 30-60 min 2-6 hrs 0.59-1.51 hrs
    Oral 30-90 min 1-3 hrs 1-2 hrs 2-6 hrs 2.5-6.5 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 5.6
    Strong 6/10

    Strong visuals with mild body load, headspace, and auditory effects

    Visual Intensity ×3
    8
    color enhancement drifting tracers pattern recognition enhancement visual distortions
    Headspace Depth ×3
    4
    conceptual thinking time distortion confusion
    Auditory Effects ×1
    4
    auditory distortion
    ⚠ Body Load / Somatic Effects ×1
    5
    nausea tachycardia increased heart rate
    View methodology →

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track AM-1248 there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "AM-1248 (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    AM-1248
    Unit
    mg
    Description 
    AM-1248
Source: SubstanceSearch (substancesearch.com)

Vaporized dose (mg): threshold 0.3 · light 0.3-1 · common 1-3 · strong 3-5 · heavy 5+
Oral dose (mg): threshold 1 · light 1-3 · common 3-6 · strong 6-10 · heavy 10+

Vaporized duration: onset 36s · peak 5-30m · offset 0.5-1h · total 0.59-1.51h · after-effects 2-6h
Oral duration: onset 0.5-1.5h · peak 1-3h · offset 1-2h · total 2.5-6.5h · after-effects 2-6h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 2 mg (Vaporized).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops over weeks of regular use via CB1 receptor downregulation
    Reset 2–4 weeks for most users; heavy users may need longer

    Tolerance Decay

    Full tolerance 3d Half tolerance 14d Baseline ~28d

    Tolerance and cross‑tolerance patterns are inferred from user surveys and clinical observations of SCRAs as a class; quantitative values are illustrative to help plan spacing between sessions and should not be treated as precise pharmacometrics.

    Cross-Tolerances

    Cannabis (THC)
    50%
    Other synthetic cannabinoids
    70%

    Effects dose.wiki

    Positive
    • Bodily warmth
    • Stimulation
    • Physical euphoria
    Negative
    • Tachycardia
    • Nausea
    • Increased heart rate
    • Pupil dilation
    • Insomnia
    Neutral
    • Xerostomia
    • Sedation
    Positive
    • Euphoria
    • Anxiety suppression
    • Conceptual thinking
    • Analysis enhancement
    • Empathy
    Negative
    • Anxiety
    • Memory suppression
    • Confusion
    • Motor control loss
    Neutral
    • Time distortion
    Positive
    • Tactile enhancement
    • Color enhancement
    • Tracers
    • Increased music appreciation
    • Enhanced tactile sensation
    • Pattern recognition enhancement
    Neutral
    • Visual snow
    • Visual distortions
    • Drifting
    • Auditory distortion

    Combinations

    Cross-Check AM-1248 with another substance

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.

    Bluelight 1 thread 1 neutral visit
    Am 1248 First Time Sativa Lovers Delight neutral

    Weight: 110 lbs Age: late 20s Experience: marijuana, herbal incense (unknown), jwh-122, am-2201 Set/Setting: good mood, slightly tired after long day at work. home alone on a Friday evening. ROA: oral/sublingual, smoked. Ingestion: Started with a small pinch (eyeballed.

    scraped 2026-03-14
    AM-1248's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki