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    Amantadine Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • PubChem toxicity data

    Summary

    Amantadine is an antiviral drug used for the prophylactic or symptomatic treatment of influenza A, and also as an antiparkinsonian agent to treat extrapyramidal reactions and postherpetic neuralgia. Its antiparkinsonian effect is not fully understood but appears to involve increasing the synthesis and release of dopamine from brain cell nerve endings, possibly inhibiting dopamine uptake, and stimulating the norepinephrine response; it also acts as an NMDA receptor antagonist. Its antiviral mechanism is unrelated, interfering with the viral M2 protein (an ion channel) needed for the viral particle to become uncoated after entering the cell by endocytosis.

    Dose Information PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 100-300mg 300-450mg 450-600mg 600mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects PsychonautWiki

    ROA Onset Peak Offset Total
    Oral 30-90 min 3-5 hrs 24-48 hrs 12-48 hrs

    Effects

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.

    Erowid 2 reports 1 neutral 1 cautionary visit
    I Took the Whole Box and Went to Sleep for 2 Hours neutral exp #114936

    Amantadine Madness T- 4pm: I was searching through my medical cabinet, hoping to find something good and all I found were pills with amantadine, I started teaching for info and all I found was that this could cause delirium at really high doses, so I took the whole box and went to sleep for 2 hours.

    Joel · 1500 mg oral
    Hmm.. Not Worth It cautionary exp #111596

    So, friend found a bottle of so called 'Amantadine', idk what it's use for So yesterday i eated five of them Durning a day, and 5 pills gave me feelings of dissociation, and believe me or not, mdma! I come to home, and everything seems distanced and weird, body high is light to moderare dissociation and everything is o...

    Cyan203 · 500 - 1400 mg oral
    Bluelight 1 thread 1 neutral visit
    The Amantadine Trip Report neutral

    I acquired a pretty decent amount from Very reutable source I took about 2-4grams, I figured this would alright to eyeball seeing how the max single dose of amantadine is 100mg and being that it's compared with memantine and the only memantine trip report says that about half a gram really doesn't do too much but lasts...

    scraped 2026-03-14

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