Summary
AMB-CHMICA is a highly potent synthetic cannabinoid with full CB1 and CB2 receptor agonism. Even sub-milligram dosing errors can cause severe toxicity including seizures, hyperemesis, tachyarrhythmia, acute psychosis, and loss of consciousness. Hot-spot formation in herbal blends is common; use a milligram-accurate scale and volumetric dosing. Multiple severe intoxications and several deaths have been documented across Europe and North America. Synthetic cannabinoids carry significantly higher risk than natural cannabis.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Smoked | 1 min | 2-5 min | 5-30 min | 1-2 hrs | 6 hrs |
| Oral | 15-60 min | 30-90 min | 1-2 hrs | 2-4 hrs | 6 hrs |
Tolerance
Build-up
develops over weeks of regular use via CB1 receptor downregulation
Reset
2–4 weeks for most users; heavy users may need longer
Effects
Positive
- Physical euphoria
- Pain relief
Negative
- Tachycardia
- Increased heart rate
- Vertigo
- Dry mouth
- Nausea
- Temperature regulation suppression
- Increased blood pressure
- Sedation
- Red eyes
- Spontaneous bodily sensations
Positive
- Euphoria
- Cognitive euphoria
Negative
- Anxiety
- Paranoia
- Thought disorganization
- Memory suppression
- Analysis suppression
- Motivation suppression
- Depersonalization
- Derealization
- Dizziness
- Motor control loss
- Time distortion
Positive
- Pattern recognition enhancement
- Appetite enhancement
- Bodily control enhancement
- Color enhancement
- Appetite Enhancement
- Increased Music Appreciation
Negative
- Dehydration
- Visual disconnection
- Visual distortions
- Spontaneous Physical Sensations