Summary
APICA (also known as SDB-001, and 2NE1) is a novel synthetic cannabinoid that produces modified cannabis-like effects when administered. It has been shown to act as a potent agonist for the CB1 and CB2 cannabinoid receptors.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Smoked | 0.5-1.5mg | 1.5-2mg | 2-4mg | 4mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects |
|---|---|---|---|---|
| Smoked | 0 min | 12-30 min | 6-12 min | 12-36 min |
Tolerance
Build-up
develops over weeks of regular use via CB1 receptor downregulation
Reset
2–4 weeks for most users; heavy users may need longer
Effects
Positive
- Pain relief
- Stimulation
Negative
- Dry mouth
- Tachycardia
- Nausea/vomiting
- Strong dysphoria on comedown
- Nausea
- Spontaneous bodily sensations
- Vasodilation
- Red eyes
Positive
- Thought connectivity
- Mindfulness
- Conceptual thinking
Negative
- Anxiety
- Paranoia
- Thought deceleration
- Dream suppression
- Motor control loss
- Psychosis
- Emotion intensification
Positive
- Increased music appreciation
- Auditory acuity enhancement
Negative
- Dehydration
- Auditory distortion
- Changes in felt gravity
- Perception of bodily heaviness
- Appetite intensification
- Visual sharpening or mild pseudo-hallucinations
- Dulled perception
- Drifting