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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    Arimistane Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 3 ROAs with full dose ladders
    • duration data present
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: Estrovade, 3-deoxy-7-oxo-dhea, Androst-3,5-dien-7,17-dione, 3,5-androstadiene-7,17-dione

    Research-chemical

    Summary dose.wiki

    Arimistane is a suicide aromatase inhibitor banned by WADA and considered unsafe by the FDA for use as a dietary supplement. Run baseline labs before use, then retest estradiol (E2-sensitive LC-MS/MS), total/free testosterone, SHBG, AST/ALT, and lipid panel every 2 weeks during use. Limit cycles to 6 weeks maximum followed by at least 4 weeks off to restore aromatase enzyme levels.

    Dose Information dose.wiki Drugs.Wiki

    Dose basis. Community-reported only; no human pharmacokinetics or dosing trials located in the literature. Product purity/potency varies widely across supplement brands. Anecdotal practice to speed onset; formal bioavailability data are lacking. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Oral 12.5-25mg 25-50mg 50-75mg 75mg+
    Sublingual 10-15mg 15-30mg 30-45mg 45mg+
    Transdermal 25-50mg 50-75mg 75-100mg 100mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 30-60 min 1-2 hrs 4-6 hrs 12-24 hrs 24-72 hrs 17.5-33 hrs
    Sublingual 15-30 min 45-90 min 3-5 hrs 12-24 hrs 24-72 hrs 16-31 hrs
    Transdermal - - 4-6 hrs 12-24 hrs 24-72 hrs 24-48 hrs

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track Arimistane there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "Arimistane (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    Arimistane
    Unit
    mg
    Description 
    Arimistane
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 12.5 · light 12.5-25 · common 25-50 · strong 50-75 · heavy 75+
Sublingual dose (mg): threshold 5-10 · light 10-15 · common 15-30 · strong 30-45 · heavy 45+
Transdermal dose (mg): threshold 25 · light 25-50 · common 50-75 · strong 75-100 · heavy 100+

Oral duration: onset 0.5-1h · come-up 1-2h · peak 4-6h · offset 12-24h · total 17.5-33h · after-effects 24-72h
Sublingual duration: onset 15-30m · come-up 0.75-1.5h · peak 3-5h · offset 12-24h · total 16-31h · after-effects 24-72h
Transdermal duration: peak 4-6h · offset 12-24h · total 24-48h · after-effects 24-72h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 37.5 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Tolerance Decay

    Full tolerance 42d Half tolerance 21d Baseline ~56d

    No formal tolerance data. Timings reflect community patterns (weeks of continuous daily use leading to reduced responsiveness and increased side effects), not receptor-level tolerance. Interpret as practical guidance rather than a pharmacologic model.

    Cross-Tolerances

    steroidal aromatase inhibitors (class effect)
    50%

    Effects dose.wiki

    Negative
    • Mild fatigue
    • Headache
    • Motor impairment
    Neutral
    • Dry joints
    • Creaky ligaments
    • Reduced water retention
    • Increased vascularity
    • Hot flashes
    • Night sweats
    • Sedation
    Positive
    • Reduced anxiety
    • Anxiety suppression
    • Dream potentiation
    • Enhanced dream recall
    Negative
    • Brain fog
    • Irritability
    • Elevated aggression/drive
    Neutral
    • Libido swings
    • Mood volatility
    • Mood changes
    Positive
    • Increased music appreciation
    • Color enhancement
    • Tactile enhancement
    Negative
    • Decreased libido
    • Light sensitivity
    • Appetite suppression
    • Dehydration
    • Disinhibition
    Neutral
    • Dulled perception
    • Softening of skin
    Arimistane's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki