Arimistane
Aliases: Estrovade, 3-deoxy-7-oxo-dhea, Androst-3,5-dien-7,17-dione, 3,5-androstadiene-7,17-dione
Categories
Summary
Arimistane is a suicide aromatase inhibitor banned by WADA and considered unsafe by the FDA for use as a dietary supplement. Run baseline labs before use, then retest estradiol (E2-sensitive LC-MS/MS), total/free testosterone, SHBG, AST/ALT, and lipid panel every 2 weeks during use. Limit cycles to 6 weeks maximum followed by at least 4 weeks off to restore aromatase enzyme levels. If estradiol falls below 15 pg/mL, reduce dose immediately or discontinue. Joint dryness above 75 mg/day may respond to omega-3 fatty acids (1 g EPA+DHA), collagen supplementation, and dose reduction.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 30-60 min | 1-2 hrs | 4-6 hrs | 12-24 hrs | 24-72 hrs |
| Sublingual | 15-30 min | 45-90 min | 3-5 hrs | 12-24 hrs | 24-72 hrs |
| Transdermal (Topical) | 1-2 hrs | 2-4 hrs | 4-8 hrs | 12-24 hrs | 24-72 hrs |
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Effects
Positive
Negative
- Mild fatigue
- Headache
- Motor impairment
- Dry joints
- Creaky ligaments
- Reduced water retention
- Increased vascularity
- Hot flashes
- Night sweats
- Sedation
Positive
- Reduced anxiety
- Anxiety suppression
- Dream potentiation
- Enhanced dream recall
Negative
- Brain fog
- Irritability
- Elevated aggression/drive
- Libido swings
- Mood volatility
- Mood changes
Positive
- Increased music appreciation
- Color enhancement
- Tactile enhancement
Negative
- Decreased libido
- Light sensitivity
- Appetite suppression
- Dehydration
- Disinhibition
- Dulled perception
- Softening of skin