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    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    Arimistane

    Aliases: Estrovade, 3-deoxy-7-oxo-dhea, Androst-3,5-dien-7,17-dione, 3,5-androstadiene-7,17-dione

    Depressant Research-chemical Opioid

    Summary TheDrug.Wiki

    Arimistane is a suicide aromatase inhibitor banned by WADA and considered unsafe by the FDA for use as a dietary supplement. Run baseline labs before use, then retest estradiol (E2-sensitive LC-MS/MS), total/free testosterone, SHBG, AST/ALT, and lipid panel every 2 weeks during use. Limit cycles to 6 weeks maximum followed by at least 4 weeks off to restore aromatase enzyme levels.

    Dose Information TheDrug.Wiki

    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Comeup Peak Offset After Effects
    Oral 30-60 min 1-2 hrs 4-6 hrs 12-24 hrs 24-72 hrs
    Sublingual 15-30 min 45-90 min 3-5 hrs 12-24 hrs 24-72 hrs
    Transdermal (Topical) 1-2 hrs 2-4 hrs 4-8 hrs 12-24 hrs 24-72 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 2.0
    Light 2/10

    Mild sedation

    Euphoria / Warmth ×3
    0
    Analgesia ×2
    0
    Sedation / Relaxation ×1
    4
    sedation dream potentiation
    ⚠ Itching / Nausea ×1
    0
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Arimistane
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 42d Half tolerance 21d Baseline ~56d

    No formal tolerance data. Timings reflect community patterns (weeks of continuous daily use leading to reduced responsiveness and increased side effects), not receptor-level tolerance. Interpret as practical guidance rather than a pharmacologic model.

    Cross-Tolerances

    steroidal aromatase inhibitors (class effect)
    50%

    Effects TheDrug.Wiki

    Negative
    • Mild fatigue
    • Headache
    • Motor impairment
    Neutral
    • Dry joints
    • Creaky ligaments
    • Reduced water retention
    • Increased vascularity
    • Hot flashes
    • Night sweats
    • Sedation
    Positive
    • Reduced anxiety
    • Anxiety suppression
    • Dream potentiation
    • Enhanced dream recall
    Negative
    • Brain fog
    • Irritability
    • Elevated aggression/drive
    Neutral
    • Libido swings
    • Mood volatility
    • Mood changes
    Positive
    • Increased music appreciation
    • Color enhancement
    • Tactile enhancement
    Negative
    • Decreased libido
    • Light sensitivity
    • Appetite suppression
    • Dehydration
    • Disinhibition
    Neutral
    • Dulled perception
    • Softening of skin

    Combinations TripSit

    Arimistane's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki