Bezitramide
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 3 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- dose data not in PW/TripSit (unverifiable)
- 3 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- dose data not in PW/TripSit (unverifiable)
Aliases: R-4845, Burgodin
Summary
Withdrawn from Dutch market in 2004 following pediatric fatality. Extremely delayed onset encourages dangerous redosing before peak effects manifest. Historical 5 mg tablets represented supratherapeutic doses for opioid-naive users.
Dose Information
Dose basis. The dose figures on this page come from clinical practice, where this drug is given by trained staff who are titrating to effect with airway support and monitoring immediately available. They are not a self-administration guide, and the margin they assume does not exist outside that setting. Assume full respiratory depression, keep naloxone to hand, never dose alone, and never combine with benzodiazepines, alcohol or other depressants.
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 0.5-1mg | 1-2.5mg | 2.5-5mg | 5mg+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 1-3 hrs | 2.5-5 hrs | 8-12 hrs | 11.5-20 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong euphoria with moderate itching/nausea, mild pain relief, low sedation
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Bezitramide there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Bezitramide Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 0.25-0.5 · light 0.5-1 · common 1-2.5 · strong 2.5-5 · heavy 5+ Oral duration: onset 1-3h · peak 2.5-5h · offset 8-12h · total 11.5-20h · after-effects 6-12h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 1.75 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Opioid tolerance builds rapidly with daily use and decays over weeks after cessation; cross‑tolerance is expected with other μ‑opioid agonists. Quantitative values are approximate and based on general opioid patterns rather than bezitramide‑specific trials; interpret cautiously.
Effects
- Pain relief
- Physical euphoria
- Cough suppression
- Stimulation
- Respiratory depression
- Nausea
- Tachycardia
- Sedation
- Itchiness
- Difficulty urinating
- Cognitive euphoria
- Anxiety suppression
- Reduced anxiety
- Wakefulness
- Motivation enhancement
- Euphoria
- Alertness enhancement
- Constipation
- Anxiety
- Talkativeness
- Warmth
- Increased music appreciation
- Increased libido
- Appetite suppression
- Light sensitivity
- Disinhibition
- Dehydration
- Dulled perception
- Internal hallucination
- Warm flush
Combinations
Cross-Check Bezitramide with another substanceHelpful Links
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