Bezitramide - Substance Search

Summary TheDrug.Wiki

Withdrawn from Dutch market in 2004 following pediatric fatality. Extremely delayed onset encourages dangerous redosing before peak effects manifest. Historical 5 mg tablets represented supratherapeutic doses for opioid-naive users.

Dose Information TheDrug.Wiki

Light Common Strong Heavy

Onset, Duration & After-effects TheDrug.Wiki

ROA	Onset	Peak	Offset	After Effects
Oral	1-3 hrs	2.5-5 hrs	8-12 hrs	6-12 hrs

Effect Profile

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Opioid 6.4

Strong 6/10

Strong euphoria with moderate itching/nausea, mild pain relief, low sedation

Euphoria / Warmth ×3

10

physical euphoria cognitive euphoria euphoria warmth

Analgesia ×2

4

pain relief

Sedation / Relaxation ×1

3

sedation

⚠ Itching / Nausea ×1

6

nausea constipation

Based on reports from:

Erowid Experience Reports PsychonautWiki Bezitramide

Tolerance

Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance

Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

Tolerance Decay

Full tolerance 6d Half tolerance 14d Baseline ~35d

Opioid tolerance builds rapidly with daily use and decays over weeks after cessation; cross‑tolerance is expected with other μ‑opioid agonists. Quantitative values are approximate and based on general opioid patterns rather than bezitramide‑specific trials; interpret cautiously.