Bezitramide
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 3 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 29 combo interactions documented
- dose data not in PW/TripSit (unverifiable)
- 3 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 29 combo interactions documented
- dose data not in PW/TripSit (unverifiable)
Aliases: R-4845, Burgodin
Summary
Withdrawn from Dutch market in 2004 following pediatric fatality. Extremely delayed onset encourages dangerous redosing before peak effects manifest. Historical 5 mg tablets represented supratherapeutic doses for opioid-naive users.
Dose Information
Dose basis. The dose figures on this page come from clinical practice, where this drug is given by trained staff who are titrating to effect with airway support and monitoring immediately available. They are not a self-administration guide, and the margin they assume does not exist outside that setting. Assume full respiratory depression, keep naloxone to hand, never dose alone, and never combine with benzodiazepines, alcohol or other depressants.
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 0.5-1mg | 1-2.5mg | 2.5-5mg | 5mg+ |
Sources
Oral
Dose ladder — Drugs.WikiOnset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 1-3 hrs | 2.5-5 hrs | 8-12 hrs | 11.5-20 hrs |
Effect Profile
Scores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong euphoria with moderate itching/nausea, mild pain relief, low sedation
Tolerance
No tolerance chart. Our decay curves for opioids were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.
Opioid tolerance drops fast when you stop, and even a few days off can be enough, so a dose that used to be normal can now stop your breathing. Overdose deaths rise sharply after prison, detox or leaving treatment, and tolerance also falls during a hospital stay. After any break, start with a much smaller amount, try a test dose first, don't use alone, and keep naloxone within reach. Alcohol, benzodiazepines, gabapentinoids and other sedatives make an opioid overdose much more likely.
Sources: FRANK: heroin · National Harm Reduction Coalition · WHO: opioid overdose · Merrall et al. 2010 · Binswanger et al. 2007 · Strang et al. 2003 · FDA 2019: gabapentinoids and breathing
Effects
Effect glossary — · full glossary
Combinations
Cross-Check Bezitramide with another substanceHelpful Links
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Bezitramide there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Bezitramide Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 0.25-0.5 · light 0.5-1 · common 1-2.5 · strong 2.5-5 · heavy 5+ Oral duration: onset 1-3h · peak 2.5-5h · offset 8-12h · total 11.5-20h · after-effects 6-12h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 1.75 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for Bezitramide? Let us know. Reports are reviewed by moderators — this is not posted publicly.