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    Disclaimer
    ⚠ Benzodiazepines can cause physical dependence with regular use. Withdrawal can be life-threatening. Never combine with opioids or alcohol.

    Brotizolam

    Aliases: Dormex, Noxtal, We-941, Lendorm, Goodmin, lendormin

    Depressant Benzodiazepine

    Summary TheDrug.Wiki TripSit

    Brotizolam is an extremely potent short-acting thienotriazolodiazepine prescribed for short-term treatment (2-4 weeks only) of severe insomnia. Doses are active at as little as 80 micrograms, with therapeutic doses typically 0.125-0.25 mg. Residual effects the next day may impair cognitive and motor function, particularly above 0.5 mg.

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Oral 100ug-200ug 200-400ug 400ug-600ug 600ug+
    Light Common Strong Heavy

    Benzo Equivalence Calculator

    mg
    0.25 mg Brotizolam
    =
    — mg Diazepam

    ⚠ These are approximate equivalences for educational and cross-tapering reference. Individual response, tolerance, and half-life differences mean actual equivalence varies. Always consult a healthcare provider for tapering guidance.

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Comeup Peak Offset After Effects
    Oral 15-30 min 30-45 min 1-2 hrs 4-6 hrs 12-12 hrs

    Effect Profile

    1 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Benzodiazepine 7.3
    Strong+ 7/10

    Strong anxiolysis, euphoria, and cognitive impairment with mild sedation

    Anxiolysis ×3
    10
    anxiety suppression anxiolytic muscle relaxation muscle relaxant emotion suppression
    Sedation / Relaxation ×2
    5
    sedation muscle relaxation
    ⚠ Motor / Cognitive Impairment ×1
    9
    motor control loss cognitive impairment amnesia delusions of sobriety
    Euphoria / Mood Lift ×1
    10
    cognitive euphoria physical euphoria disinhibition
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Brotizolam
    View methodology →

    Tolerance

    Build-up develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
    Reset weeks to months depending on half-life and duration of use; taper recommended

    Tolerance Decay

    Full tolerance 14d Half tolerance 7d Baseline ~28d

    As with other benzodiazepines, tolerance to sedative/hypnotic effects tends to accrue over days to weeks of regular use and decays over several weeks of abstinence. Cross‑tolerance within the class is expected; the quantitative ratios are approximate and based on clinical and community observations, not controlled head‑to‑head trials.

    Cross-Tolerances

    Other benzodiazepines
    80%
    Z-drugs
    50%

    Effects TheDrug.Wiki TripSit

    Positive
    • Muscle relaxation
    • Physical euphoria
    • Anxiolytic
    • Muscle Relaxant
    Negative
    • Respiratory depression
    • Motor impairment
    Neutral
    • Sedation
    • Sedative
    • Dystaxia
    • Hypnotic
    Positive
    • Anxiety suppression
    • Cognitive euphoria
    Negative
    • Motor control loss
    • Amnesia
    • Emotion suppression
    • Cognitive impairment
    • Delusions of sobriety
    • Compulsive redosing
    • Thought deceleration
    • Delusions
    Positive
    • Increased libido
    • Appetite enhancement
    • Increased music appreciation
    Negative
    • Disinhibition
    • Visual acuity suppression
    • Acuity suppression
    • Dehydration
    • Light sensitivity
    Neutral
    • Dulled perception
    • Perception of bodily heaviness

    Combinations TripSit

    Brotizolam's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

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