Brotizolam
Aliases: Dormex, Noxtal, We-941, Lendorm, Goodmin, lendormin
Categories
Summary
Brotizolam is an extremely potent short-acting thienotriazolodiazepine prescribed for short-term treatment (2-4 weeks only) of severe insomnia. Doses are active at as little as 80 micrograms, with therapeutic doses typically 0.125-0.25 mg. Residual effects the next day may impair cognitive and motor function, particularly above 0.5 mg. Not approved for sale in the UK, US, or Canada. Requires special precaution in elderly patients, during pregnancy, and in those with substance abuse history.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 100ug-200ug | 200-400ug | 400ug-600ug | 600ug+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 15-30 min | 30-45 min | 1-2 hrs | 4-6 hrs | 12 hrs |
Tolerance
Build-up
develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
Reset
weeks to months depending on half-life and duration of use; taper recommended
Effects
Positive
- Muscle relaxation
- Physical euphoria
- Anxiolytic
- Muscle Relaxant
Negative
- Respiratory depression
- Motor impairment
- Sedation
- Sedative
- Dystaxia
- Hypnotic
Positive
- Anxiety suppression
- Cognitive euphoria
Negative
- Motor control loss
- Amnesia
- Emotion suppression
- Cognitive impairment
- Delusions of sobriety
- Compulsive redosing
- Thought deceleration
- Delusions
Positive
- Increased libido
- Appetite enhancement
- Increased music appreciation
Negative
- Disinhibition
- Visual acuity suppression
- Acuity suppression
- Dehydration
- Light sensitivity
- Dulled perception
- Perception of bodily heaviness