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    ⚠ Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    Buprenorphine

    Aliases: Bupe, Subs, Sobos, Strips, Nalone, suboxone

    Categories

    Depressant Opioid
    Buprenorphine structure

    Summary TheDrug.Wiki Erowid TripSit PsychonautWiki

    Buprenorphine is a partial μ-opioid agonist and κ-opioid antagonist used for opioid use disorder treatment and pain management. It has a ceiling effect for respiratory depression and euphoria at therapeutic doses, making it safer than full opioid agonists. However, this ceiling effect is removed when combined with benzodiazepines or alcohol. When used for opioid dependence treatment, buprenorphine must be started when moderate withdrawal symptoms appear to avoid precipitated withdrawal. Often combined with naloxone (Suboxone) to deter IV misuse, though naloxone's deterrent effect has been questioned.

    Dose Information TheDrug.Wiki TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Sublingual 1-2mg 2-4mg 4-8mg 8mg+
    Oral 0.2-0.4mg 0.4-0.8mg 0.8-1.5mg 1.5mg+
    Insufflated 0.2-0.4mg 0.4-0.8mg 0.8-1.5mg 1.5mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects
    Sublingual 30-80 min 1-2 hrs 1.5-4 hrs 6-12 hrs 24-72 hrs
    Transdermal 12-24 hrs - 24-48 hrs 12-24 hrs 24-72 hrs
    Intravenous 2-5 min 5-15 min 30-60 min 4-8 hrs 12-24 hrs
    Intramuscular 15-30 min 30-60 min 1-2 hrs 4-8 hrs 12-24 hrs
    Oral 60-90 min - - - 1.0-16.0 hrs
    Insufflated 30-60 min - 4-8 hrs - 1-3 hrs

    Tolerance

    Build-up develops slowly due to partial agonist ceiling; still produces opioid cross-tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
    Cross-tolerance
    Morphine Heroin Oxycodone Fentanyl Codeine Tramadol Kratom Methadone

    Effects TheDrug.Wiki TripSit

    Positive
    • Analgesia
    • Physical euphoria
    • Pain relief
    • Cough suppression
    Negative
    • Respiratory depression
    • Nausea
    • Dry Mouth
    Neutral
    • Sedation
    • Itchiness
    • Difficulty urinating
    • Relaxant
    • Pupil constriction
    Positive
    • Cognitive euphoria
    • Anxiety suppression
    • Euphoria
    • Mood lift
    • Cognitive Euphoria
    • Anxiety Suppression
    • Dream potentiation
    Negative
    • Constipation
    • Dizziness
    • Compulsive redosing
    Positive
    • Visual geometry
    • Increased music appreciation
    Negative
    • Appetite suppression
    • Decreased Libido
    • Appetite Suppression
    • Spatial disorientation
    Neutral
    • Dulled perception
    • Internal hallucinations
    • Internal hallucination
    • Visual and auditory hallucinations

    Combinations TripSit

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