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    Disclaimer
    ⚠ Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    Buprenorphine

    Aliases: Bupe, Subs, Sobos, Strips, Nalone, suboxone

    Depressant Opioid

    Summary TheDrug.Wiki Erowid TripSit PsychonautWiki

    Buprenorphine is a partial μ-opioid agonist and κ-opioid antagonist used for opioid use disorder treatment and pain management. It has a ceiling effect for respiratory depression and euphoria at therapeutic doses, making it safer than full opioid agonists. However, this ceiling effect is removed when combined with benzodiazepines or alcohol.

    Dose Information TheDrug.Wiki TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Sublingual 1-2mg 2-4mg 4-8mg 8mg+
    Oral 0.2-0.4mg 0.4-0.8mg 0.8-1.5mg 1.5mg+
    Insufflated 0.2-0.4mg 0.4-0.8mg 0.8-1.5mg 1.5mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects
    Sublingual 30-80 min 1-2 hrs 1.5-4 hrs 6-12 hrs 24-72 hrs
    Transdermal 12-24 hrs - 24-48 hrs 12-24 hrs 24-72 hrs
    Intravenous 2-5 min 5-15 min 30-60 min 4-8 hrs 12-24 hrs
    Intramuscular 15-30 min 30-60 min 1-2 hrs 4-8 hrs 12-24 hrs
    Oral 60-90 min - 1.5-2 hrs 4-8 hrs 1-16 hrs
    Insufflated 30-60 min - 4-8 hrs - 1-3 hrs

    Opioid MME Calculator

    ⚠ Citation & Disclaimer: Conversion factors sourced from the NIH HEAL Initiative MME Calculator (Adams et al., PAIN 2025), the CDC 2022 Clinical Practice Guideline for Prescribing Opioids for Pain, and the MDCalc MME Calculator. These are approximate equianalgesic ratios for educational reference only. Individual responses vary significantly based on genetics, tolerance, cross-tolerance, and route of administration. This is not medical advice. Do not use these conversions to adjust opioid dosing without professional medical guidance.
    mg
    0.26 mg Buprenorphine
    ≈
    — mg Morphine

    ⚠ Equianalgesic dose ratios are approximations and do not account for genetic factors, tolerance, incomplete cross-tolerance, or pharmacokinetic variations. Methadone conversion is especially variable at higher doses. Always consult a healthcare provider before making any changes to opioid therapy.

    Effect Profile

    178 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Validated against 152 Erowid trip reports
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 8.1
    Intense 8/10

    Strong euphoria, pain relief, and itching/nausea with moderate sedation

    Euphoria / Warmth ×3
    10
    physical euphoria cognitive euphoria euphoria mood lift
    Analgesia ×2
    10
    analgesia pain relief
    Sedation / Relaxation ×1
    7
    sedation dream potentiation
    ⚠ Itching / Nausea ×1
    10
    nausea constipation dry mouth
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Buprenorphine
    View methodology →

    Tolerance

    Build-up develops slowly due to partial agonist ceiling; still produces opioid cross-tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 7d Half tolerance 3d Baseline ~14d

    Tolerance accrues with repeated dosing and decays slowly after cessation. Risky behaviors arise when users underestimate tolerance loss during/after taper or detox and resume previous opioid doses.

    Cross-Tolerances

    Other opioids
    60%

    Effects Erowid Bluelight

    Aggregated from 152 Erowid and 26 Bluelight experience reports

    Positive Effects 34

    Contentment 34.6% 84%
    Euphoria 34.3% 89%
    Sedation 28.7% 84%
    Stimulation 24.7% 82%
    Anxiety Suppression 23.6% 79%
    Empathy 20.2% 80%
    Sociability Enhancement 15.4% 86%
    Tactile Enhancement 10.6% 85%
    Music Enhancement 10.5% 70%
    Focus Enhancement 9.6% 71%
    Pain Relief 9.5% 87%
    Body High 8.4% 83%
    Mood Lift 7.7% 78%
    Itching 7.7% 90%
    Empathogenic Connection 7.7% 82%
    Peace 7.7% 88%
    Emotional Openness 7.7% 82%
    Catharsis 3.8% 90%
    Tactile Intimacy Enhancement 3.8% 80%
    Memory Enhancement 3.8% 75%

    Adverse Effects 35

    Nausea 27.5% 84%
    Body Load 23.1% 79%
    Vomiting 19.2% 94%
    Confusion 13.5% 80%
    Dysphoria 11.5% 87%
    Urinary Retention 11.5% 85%
    Dizziness 11.5% 88%
    Insomnia 11.5% 83%
    Headache 8.4% 83%
    Sweating 8.4% 87%
    Visual Distortions 3.9% 90%
    Motor Impairment 3.9% 80%
    Dry Mouth 3.8% 95%
    Sadness 3.8% 90%
    Emotional Suppression 3.8% 85%
    Heart Rate Increase 3.8% 85%
    Environmental Transfiguration 3.8% 90%
    Amnesia 3.8% 90%
    Tremor 3.8% 85%
    Time Dilation 3.8% 85%

    Combinations TripSit

    Pill Identifiers

    2 known pill identifiers on record — view imprints, colors, shapes, and images
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    Buprenorphine's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

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