🧪This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
⚠Synthetic cannabinoids are far more potent and unpredictable than natural cannabis. They lack a ceiling effect and have been linked to seizures, psychosis, and death.
• CB-13 is designed to stay largely outside the blood–brain barrier, providing peripheral CB₁/CB₂ activity (analgesia, anti-inflammatory) with greatly reduced central psychoactivity.
• Recreational 'high' is weak or absent below very large doses; most user reports describe mild body relaxation, analgesia and sleepiness rather than classic cannabis effects.
• Because effective doses are hundreds of milligrams orally, material cost, impurities and liver load become significant concerns.
• Limited human data – no formal safety studies. Start with allergy test (<5 mg vaped or <25 mg oral).
• May cause dose-dependent hypotension, tachycardia, dry mouth, nausea, and impaired motor coordination. Very high doses in rodents produced hypothermia and catalepsy.
• Avoid driving for at least 6 h after use.
• Being peripherally restricted does NOT guarantee absence of central effects if very large doses are taken or if the blood–brain barrier is compromised (e.g., by alcohol or inflammation).
Dose Information
TheDrug.Wiki
ROA
Light
Common
Strong
Heavy
Oral
-
-
-
450mg+(notrecommended)+
Vaporized
-
-
-
>50mg(littleadditionaleffect)+
LightCommonStrongHeavy
Onset, Duration & After-effects
TheDrug.Wiki
ROA
Onset
Peak
Offset
After Effects
Oral
30-90 min
2-4 hrs
2-4 hrs
2-6 hrs
Vaporized
1-5 min
30-90 min
1-2 hrs
2-6 hrs
Tolerance
Build-updevelops over weeks of regular use via CB1 receptor downregulation
Reset2–4 weeks for most users; heavy users may need longer
