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    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Synthetic cannabinoids are far more potent and unpredictable than natural cannabis. They lack a ceiling effect and have been linked to seizures, psychosis, and death.

    CB-13 Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 16 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: Cra-13, Sab-378

    Depressant Psychedelic Research-chemical Cannabinoid

    Summary dose.wiki

    CB-13 is designed to stay largely outside the blood–brain barrier, providing peripheral CB₁/CB₂ activity (analgesia, anti-inflammatory) with greatly reduced central psychoactivity. Recreational 'high' is weak or absent below very large doses; most user reports describe mild body relaxation, analgesia and sleepiness rather than classic cannabis effects. Because effective doses are hundreds of milligrams orally, material cost, impurities and liver load become significant concerns.

    Dose Information dose.wiki Drugs.Wiki

    Dose basis. No clinical dosing guidelines; values are aggregated from community reports and small-user self-experiments. High lipophilicity suggests food/meal fat may increase exposure (inference from CBD PK; if eating with high-fat meals expect stronger effects). Users report low volatility and inefficient aerosolization; risk of thermal decomposition/pyrolysis products as with other synthetic cannabinoids; use caution and low temperatures if attempted. Avoid herbal-carrier ‘blend’ preparations due to uneven distribution (‘hot pockets’) seen with synthetic cannabinoids generally. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Oral 75-150mg 150-300mg 300-450mg 450mg+ (not recommended)
    Vaporized 10-15mg 15-30mg (inefficient) 30-50mg 50mg+ (little additional effect)
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Peak Offset After Effects Total
    Oral 30-90 min 2-4 hrs 2-4 hrs 2-6 hrs 4.5-9.5 hrs
    Vaporized 1-5 min 30-90 min 1-2 hrs 2-6 hrs 1.52-3.58 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 5.6
    Strong 6/10

    Moderate visuals with mild headspace and auditory effects, low body load

    Visual Intensity ×3
    7
    color enhancement drifting tracers pattern recognition enhancement
    Headspace Depth ×3
    4
    conceptual thinking time distortion confusion
    Auditory Effects ×1
    4
    auditory distortion
    ⚠ Body Load / Somatic Effects ×1
    2
    nausea
    View methodology →

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track CB-13 there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "CB-13 (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    CB-13
    Unit
    mg
    Description 
    CB-13
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 50 · light 75-150 · common 150-300 · strong 300-450 · heavy 450+ (not recommended)
Vaporized dose (mg): threshold 5 · light 10-15 · common 15-30 (inefficient) · strong 30-50 · heavy 50+ (little additional effect)

Oral duration: onset 0.5-1.5h · peak 2-4h · offset 2-4h · total 4.5-9.5h · after-effects 2-6h
Vaporized duration: onset 1-5m · peak 0.5-1.5h · offset 1-2h · total 1.52-3.58h · after-effects 2-6h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 225 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops over weeks of regular use via CB1 receptor downregulation
    Reset 2–4 weeks for most users; heavy users may need longer

    Tolerance Decay

    Full tolerance 5d Half tolerance 14d Baseline ~28d

    Based on cannabinoid-class tolerance patterns: repeated daily activation downregulates CB1 signaling with partial reversal over days to weeks. Data specific to CB‑13 in humans are lacking; values above are heuristic. Evidence quality: anecdotal and cannabinoid-class extrapolation.

    Cross-Tolerances

    THC and other CB1 agonists
    50%

    Effects dose.wiki

    Positive
    • Mild body euphoria/relaxation
    • Analgesia
    • Anxiolysis
    Negative
    • Sedation/drowsiness
    • Dry mouth
    • Nausea
    Neutral
    • Reddened eyes
    • Impaired coordination
    • Mild hypotension/light-headedness
    • Reduced heart rate
    Positive
    • Reduced anxiety
    • Reduced physical symptoms of anxiety
    • Decreased performance anxiety
    • Euphoria
    • Conceptual thinking
    Negative
    • Dizziness
    • Anxiety
    • Memory suppression
    • Confusion
    Neutral
    • Time distortion
    Positive
    • Tracers
    • Color enhancement
    • Tactile enhancement
    • Increased music appreciation
    • Enhanced tactile sensation
    • Pattern recognition enhancement
    Negative
    • Warmth/tingling
    Neutral
    • Dulled perception
    • Drifting
    • Auditory distortion

    Combinations

    Cross-Check CB-13 with another substance

    CB-13's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki