Summary
CBDA is the raw acidic precursor of CBD found in fresh cannabis and hemp plants. Heating above 110°C rapidly converts it to CBD via decarboxylation, so CBDA products must remain unheated to preserve potency. In vitro and animal research shows CBDA has approximately 100-fold greater affinity for the 5-HT1A serotonin receptor compared to CBD and exhibits selective COX-2 enzyme inhibition. These mechanisms underlie its reported anti-nausea, anxiolytic, anticonvulsant, anti-inflammatory, and analgesic properties. Human anecdotal reports describe a clear-headed, mildly uplifting effect without intoxication.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 15-45 min | 30-60 min | 1-3 hrs | 1-2 hrs | 12 hrs |
| Sublingual | 5-20 min | 15-30 min | 1-3 hrs | 1-2 hrs | 12 hrs |
Tolerance
Build-up
develops over weeks of regular use via CB1 receptor downregulation
Reset
2–4 weeks for most users; heavy users may need longer
Effects
Positive
- Nausea suppression
- Pain relief
- Muscle relaxation
- Inflammation reduction
Negative
Positive
- Anxiety suppression
- Mood uplift
- Clear-headedness
- Cognitive enhancement
Negative
- Non-intoxicating