Home
    Disclaimer

    CBDA Well-documented
    Well-documented
    Multiple authoritative sources agree on dosing and effects.
    • 3 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 16 combo interactions documented
    • dose data not in PW/TripSit (unverifiable)

    Nootropic Cannabinoid

    Summary dose.wiki

    CBDA is the raw acidic precursor of CBD found in fresh cannabis and hemp plants. Heating above 110°C rapidly converts it to CBD via decarboxylation, so CBDA products must remain unheated to preserve potency. In vitro and animal research shows CBDA has approximately 100-fold greater affinity for the 5-HT1A serotonin receptor compared to CBD and exhibits selective COX-2 enzyme inhibition.

    Dose Information dose.wiki Drugs.Wiki

    Dose basis. Ranges synthesized from manufacturer COAs and user reports; no standardized human dosing trials for purified CBDA. Start at low end if on interacting medications or if sensitive to serotonergic agents. Hold under tongue 60–120 s before swallowing. Lower doses often reported effective vs oral; data largely anecdotal. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Oral 5-10mg 10-30mg 30-60mg 60mg+
    Sublingual 2-6mg 6-20mg 20-40mg 40mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 15-45 min 30-60 min 1-3 hrs 1-2 hrs 12 hrs 2.75-6.75 hrs
    Sublingual 5-20 min 15-30 min 1-3 hrs 1-2 hrs 12 hrs 2.33-5.83 hrs

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track CBDA there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "CBDA (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    CBDA
    Unit
    mg
    Description 
    CBDA
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 2 · light 5-10 · common 10-30 · strong 30-60 · heavy 60+
Sublingual dose (mg): threshold 1 · light 2-6 · common 6-20 · strong 20-40 · heavy 40+

Oral duration: onset 15-45m · come-up 0.5-1h · peak 1-3h · offset 1-2h · total 2.75-6.75h · after-effects 12h
Sublingual duration: onset 5-20m · come-up 15-30m · peak 1-3h · offset 1-2h · total 2.33-5.83h · after-effects 12h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 20 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops over weeks of regular use via CB1 receptor downregulation
    Reset 2–4 weeks for most users; heavy users may need longer

    Tolerance Decay

    Half tolerance 14d Baseline ~28d

    No controlled data. Repeated daily use appears to show minimal escalation needs anecdotally; any tolerance seems to be modest and reverses within 2–4 weeks off use.

    Cross-Tolerances

    CBD (partial)
    30%

    Effects dose.wiki

    Positive
    • Nausea suppression
    • Pain relief
    • Muscle relaxation
    • Inflammation reduction
    Positive
    • Anxiety suppression
    • Mood uplift
    • Clear-headedness
    • Cognitive enhancement
    Neutral
    • Non-intoxicating

    Combinations

    Cross-Check CBDA with another substance

    CBDA's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki