Summary
Clinical studies using doses up to 800 mg twice daily for 8 weeks have shown good safety with mostly mild gastrointestinal upset and somnolence. Like CBD, CBDV is a moderate inhibitor of several CYP450 enzymes; use caution with narrow-therapeutic-index drugs. Early evidence suggests anticonvulsant, anti-inflammatory and possible nootropic or attention-enhancing properties. Psychoactive effects are generally subtle or absent; some users describe a clear-headed, slightly stimulating sensation of bodily calm. Because extracts often contain other cannabinoids, confirm lab reports to estimate actual CBDV content before dosing.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects |
|---|---|---|---|---|
| Oral | 0.5-2 hrs | 2-4 hrs | 2-3 hrs | 12 hrs |
| Smoked | 0-5 min | 15-60 min | 1-2 hrs | 12 hrs |
Tolerance
Build-up
develops over weeks of regular use via CB1 receptor downregulation
Reset
2–4 weeks for most users; heavy users may need longer
Effects
Positive
- Mild anxiolysis
- Decreased seizure frequency
- Reduced inflammation or pain
Negative
Positive
- Subtle mood elevation
- Enhanced mental clarity or focus
Negative
- Very low or absent intoxication