CBDV
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 3 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 16 combo interactions documented
- dose data not in PW/TripSit (unverifiable)
- 3 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 16 combo interactions documented
- dose data not in PW/TripSit (unverifiable)
Aliases: Gwp42006, Cannabidivarol
Summary
Clinical studies using doses up to 800 mg twice daily for 8 weeks have shown good safety with mostly mild gastrointestinal upset and somnolence. Like CBD, CBDV is a moderate inhibitor of several CYP450 enzymes; use caution with narrow-therapeutic-index drugs. Early evidence suggests anticonvulsant, anti-inflammatory and possible nootropic or attention-enhancing properties.
Dose Information
Dose basis. Human dosing data for purified CBDV are limited; ranges below synthesize clinical exposures to GW’s CBDV (GWP42006) and user reports. Oral bioavailability is low and variable for lipophilic cannabinoids; a high‑fat meal can increase exposure (shown for CBD; CBDV likely similar). Start low and titrate slowly, especially if taking other CYP‑metabolised medicines. Product labels may include total cannabinoids rather than pure CBDV; verify lab reports. Inhaled CBDV mainly comes from CBDV‑rich hemp flower or concentrates; actual delivered CBDV is highly product‑dependent because CBDV content varies and CBDVA decarboxylation may be incomplete. Redose cautiously after 10–15 minutes to assess effect. (Dose figures and this note are from Drugs.Wiki.)
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 20-50mg | 50-200mg | 200-400mg | 400mg+ |
| Smoked | 2-5mg | 5-15mg | 15-30mg | 30mg+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 0.5-2 hrs | 2-4 hrs | 2-3 hrs | 4.5-9 hrs |
| Smoked | 0-5 min | 15-60 min | 1-2 hrs | 1.25-3.08 hrs |
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track CBDV there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
CBDV Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 10 · light 20-50 · common 50-200 · strong 200-400 · heavy 400+ Smoked dose (mg): threshold 1 · light 2-5 · common 5-15 · strong 15-30 · heavy 30+ Oral duration: onset 0.5-2h · peak 2-4h · offset 2-3h · total 4.5-9h · after-effects 12h Smoked duration: onset 0-5m · peak 0.25-1h · offset 1-2h · total 1.25-3.08h · after-effects 12h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 125 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
No clear evidence of clinically meaningful tolerance with daily CBDV over weeks to months in limited trials/anecdotes; if present, likely mild and reversible. Cross‑tolerance with CBD is plausible due to overlapping mechanisms, but magnitude is uncertain.
Cross-Tolerances
Effects
- Mild anxiolysis
- Decreased seizure frequency
- Reduced inflammation or pain
- Subtle mood elevation
- Enhanced mental clarity or focus
- Very low or absent intoxication
Combinations
Cross-Check CBDV with another substanceHelpful Links
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for CBDV? Let us know. Reports are reviewed by moderators — this is not posted publicly.