Summary
Cannabis (also known as THC, marijuana, weed, pot, grass, hemp, and many others) is a preparation of the cannabis plant that produces psychoactive effects when consumed (via smoking, vaporizing, or ingestion). It is the most used illicit substance in the world. The mechanism of action is binding activity at cannabinoid receptors distributed throughout the body.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset |
|---|---|---|---|
| Oral | 30-90 min | 1-2 hrs | 2-4 hrs |
| Sublingual | 10-30 min | 1-2 hrs | 1-3 hrs |
Tolerance
Build-up
develops over weeks of regular use via CB1 receptor downregulation
Reset
2–4 weeks for most users; heavy users may need longer
Cross-Tolerances
Effects
Positive
- Physical euphoria
- Pain relief
- Inflammation suppression
- Stimulation
Negative
- Dry mouth
- Increased heart rate
- Sedation
- Dry eyes
- Decreased blood pressure
- Decreased heart rate
Positive
- Anxiety suppression
- Mood enhancement
- Cognitive enhancement
- Motivation enhancement
- Wakefulness
- Focus enhancement
- Memory enhancement
- Cognitive euphoria
- Focus Enhancement
Negative
- Anxiety
Positive
- Appetite enhancement
- Increased libido
- Increased music appreciation
- Increased Music Appreciation
- Color enhancement
Negative
- Light sensitivity
- Appetite suppression
- Dehydration
- Appetite Suppression
- Dulled perception
Combinations
CBG's nerd page
Pharmacology, chemical data, effect profiles, and more
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