Summary
CBG is the biosynthetic precursor of THC and CBD but produces no appreciable intoxication or euphoria. It acts as a weak partial agonist at CB1/CB2 receptors with low affinity, but is a potent ฮฑ2-adrenergic agonist and 5-HT1A antagonist, which may underlie its alert-yet-calm profile. Human clinical trial data (20 mg oral) demonstrated significant anxiety reduction without cognitive impairment. Safety concerns exist due to ฮฑ2-adrenergic activation potentially causing sedation, dry mouth, and reduced blood pressure/heart rate. Metabolized primarily by CYP2J2, CYP2C9, CYP2C19, and CYP3A4 enzymes.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects |
|---|---|---|---|---|
| Oral | 30-90 min | 1-2 hrs | 2-4 hrs | 4 hrs |
| Sublingual | 10-30 min | 1-2 hrs | 1-3 hrs | 4 hrs |
| Vaporized | 1-5 min | 15-30 min | 30-90 min | 4 hrs |
Tolerance
Build-up
develops over weeks of regular use via CB1 receptor downregulation
Reset
2โ4 weeks for most users; heavy users may need longer
Effects
Positive
- Physical euphoria
- Pain relief
- Inflammation suppression
- Stimulation
Negative
- Dry mouth
- Increased heart rate
- Sedation
- Dry eyes
- Decreased blood pressure
- Decreased heart rate
Positive
- Anxiety suppression
- Mood enhancement
- Cognitive enhancement
- Motivation enhancement
- Wakefulness
- Focus enhancement
- Memory enhancement
- Cognitive euphoria
- Focus Enhancement
Negative
- Anxiety
Positive
- Appetite enhancement
- Increased libido
- Increased music appreciation
- Increased Music Appreciation
- Color enhancement
Negative
- Light sensitivity
- Appetite suppression
- Dehydration
- Appetite Suppression
- Dulled perception