Chlordiazepoxide - Substance Search

Summary TheDrug.Wiki Erowid TripSit

Chlordiazepoxide was the first benzodiazepine synthesized and is primarily prescribed for anxiety disorders and acute alcohol withdrawal. It has a long half-life and produces long-lasting active metabolites, making it useful for tapering but inappropriate for elderly patients due to accumulation risk. Abrupt discontinuation after prolonged use can cause life-threatening withdrawal including seizures.

Dose Information TheDrug.Wiki TripSit

ROA	Light	Common	Strong	Heavy
Oral	5-10mg	10-20mg	-	20-40mg+

Light Common Strong Heavy

Benzo Equivalence Calculator

Convert from

mg

Convert to

25.0 mg Chlordiazepoxide

=

— mg Diazepam

⚠ These are approximate equivalences for educational and cross-tapering reference. Individual response, tolerance, and half-life differences mean actual equivalence varies. Always consult a healthcare provider for tapering guidance.

Onset, Duration & After-effects TheDrug.Wiki TripSit

ROA	Onset	Comeup	Peak	Offset	After Effects	Total
Oral	30-60 min	30-90 min	1-4 hrs	6-24 hrs	12-24 hrs	8-30.5 hrs

Effect Profile

12 reports

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Benzodiazepine 7.6

Intense 8/10

Strong anxiolysis and euphoria with moderate cognitive impairment, mild sedation

Anxiolysis ×3

10

anxiety suppression anxiolytic muscle relaxation muscle relaxant emotion suppression

Sedation / Relaxation ×2

5

sedation muscle relaxation

⚠ Motor / Cognitive Impairment ×1

7

motor control loss amnesia delusions of sobriety

Euphoria / Mood Lift ×1

10

cognitive euphoria physical euphoria disinhibition

Based on reports from:

Erowid Experience Reports PsychonautWiki Chlordiazepoxide

Tolerance

Build-up develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance

Reset weeks to months depending on half-life and duration of use; taper recommended

Tolerance Decay

Full tolerance 14d Half tolerance 7d Baseline ~42d

Benzodiazepine tolerance builds to sedative/anxiolytic effects within days to weeks of regular use and decays slowly over weeks after cessation. Cross‑tolerance within GABA-A positive modulators is substantial but incomplete; individual variability is large. Data derived from clinical guidance and community reports; figures are illustrative, not prescriptive.