Chlorpheniramine
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- PubChem toxicity data
- classified Tentative
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- PubChem toxicity data
- classified Tentative
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: Cpm, Piriton, Demazin, Teldrin, Allerest, 4-cyclopropylmethoxy-3, cyclopropylmescaline
Summary
Chlorpheniramine is a first-generation antihistamine used for allergy relief. At therapeutic doses it causes drowsiness and anticholinergic effects including dry mouth, blurred vision, and urinary retention. High doses can cause delirium with realistic hallucinations.
Perspectives
“I was surprised at the fast development of this drug, with the knowledge that it was a long-laster. Twenty minutes into it I was aware of some changes, and by the end of one and a half hours there was a complete plus three. The most remarkable property is the eyes-closed imagery. No, not just imagery but fantasy. It is not completely benign, but it locks into music with an extraordinary fit. I was at one moment keenly aware of my body touching the rug, the tactile aspects of my surroundings, and then I would find that my world was simply my personal sphere of reality that kept engulfing everything about me, all completely augmented by the music. Constructed by the music. I hoped that I wouldn’t offend anyone else around me with this growing world of mine. Eyes open, there was not that much of note. Not much insight. Not much in the way of visuals. By the eighth hour an effort to sleep showed me how exposed and vunerable I was, and when I closed my eyes I needed my guards against this fantasy world. Even at the twelth hour there was no easy way to relax and sleep. Use higher dosages with caution.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 50-60mg | 60-70mg | 70-80mg | 80mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 0.5-2 hrs | 30-60 min | 2-3 hrs | 1-2 hrs | 12-18 hrs |
Effect Profile
6 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Moderate visuals with mild auditory effects and body load, low headspace
Tolerance
Tolerance Decay
With repeated daily use, subjective sedation may diminish over several days, but anticholinergic cognitive/urinary effects persist; cross-tolerance with other first-generation antihistamines is likely anecdotally but not well-quantified.
Effects
Aggregated from 6 Erowid experience reports
Positive Effects 1
Adverse Effects 1
Combinations
Cross-Check Chlorpheniramine with another substancePiHKAL / TiHKAL
“I was surprised at the fast development of this drug, with the knowledge that it was a long-laster. Twenty minutes into it I was aware of some changes, and by the end of one and a half hours there was a complete plus three. The most remarkable property is the eyes-closed imagery. No, not just imagery but fantasy. It is not completely benign, but it locks into music with an extraordinary fit. I was at one moment keenly aware of my body touching the rug, the tactile aspects of my surroundings, and then I would find that my world was simply my personal sphere of reality that kept engulfing everything about me, all completely augmented by the music. Constructed by the music. I hoped that I wouldn’t offend anyone else around me with this growing world of mine. Eyes open, there was not that much of note. Not much insight. Not much in the way of visuals. By the eighth hour an effort to sleep showed me how exposed and vunerable I was, and when I closed my eyes I needed my guards against this fantasy world. Even at the twelth hour there was no easy way to relax and sleep. Use higher dosages with caution.”
Pill Identifiers
Helpful Links
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