Chlorphentermine Stats & Data
NPS DataHub
MW183.68
FormulaC10H14ClN
CAS461-78-9
IUPAC1-(4-chlorophenyl)-2-methylpropan-2-amine
SMILES
Clc1ccc(cc1)CC(C)(C)NInChIKey
ZCKAMNXUHHNZLN-UHFFFAOYSA-N
Psychoactive Class
Stimulant
Pharmacology
DrugBank
Half-life 40 hours
State Solid
Description
A sympathomimetic agent that was formerly used as an anorectic. It has properties similar to those of dextroamphetamine. It has been implicated in lipid storage disorders and pulmonary hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1223)
Pharmacodynamics
Chlorphentermine is a relatively weak stimulant with little abuse potential. It presents a prominent serotonergic profile leading to pulmonary hypertension and cardiac fibrosis after prolonged use. Thus, this drug is no longer used.
Absorption
Well absorbed following oral administration.
Indication
Used as an appetite suppressant.
Effect Profile
Curated
Stimulant
6.5
Strong euphoria and anxiety/jitters with moderate focus and stimulation
Stimulation / Energy×3
6
Euphoria / Mood Lift×2
10
Focus / Productivity×2
7
Anxiety / Jitters×1
10
Based on reports from:
Tolerance & Pharmacokinetics
drugs.wikiTolerance Decay
Full tolerance
1d
Half tolerance
10d
Baseline
~18d