Summary
Citicoline (CDP-choline, cytidine 5'-diphosphocholine) is a water soluble nutrient which serves as a precursor to both choline and cytidine within the brain (which later converts to uridine). To humans, choline is an essential nutrient as its role in reducing the risk of neural tube defects, fatty liver disease, and other pathologies have been documented. CDP-choline is one of the three choline-containing phospholipids that can be orally supplemented (the other two being alpha-GPC and phosphatidylcholine).
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 100-250mg | 250-1000mg | 1000-2000mg | 2000mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 1-2 hrs | 2-3 hrs | 2.5-3.5 hrs | 30-40 hrs | 40-60 hrs |
Tolerance
Build-up
varies by mechanism; therapeutic tolerance may develop over weeks of regular use
Reset
typically days to weeks after discontinuation
Effects
Positive
- Stimulation
- Pain Relief
Negative
- Headaches
- Headache
- Nausea
- Jaw tremor
- Body Odor Alteration
- Increased saliva production
- GI peristalsis
- Bradycardia
Positive
- Memory Enhancement
- Focus Enhancement
- Wakefulness
- Dream Potentiation
- Mindfulness
- Addiction Suppression
- Enhanced Focus
- Mental Clarity
- Mood Enhancement
Negative
- Improved Memory
Positive
- Acuity Enhancement
- Bodily Control Enhancement
- Visual Acuity Enhancement
Negative
- Appetite Suppression
- Light sensitivity
- Warm facial flushing
- Appetite suppression
- Olfactory Intensification
- Drifting
- Internal hallucination