Citicoline
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
Aliases: Cdp-choline, Cytidine diphosphate choline
Summary
Citicoline (CDP-choline, cytidine 5'-diphosphocholine) is a water soluble nutrient which serves as a precursor to both choline and cytidine within the brain (which later converts to uridine). To humans, choline is an essential nutrient as its role in reducing the risk of neural tube defects, fatty liver disease, and other pathologies have been documented. CDP-choline is one of the three choline-containing phospholipids that can be orally supplemented (the other two being alpha-GPC and phosphatidylcholine).
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 100-250mg | 250-1000mg | 1000-2000mg | 2000mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset |
|---|---|---|---|---|
| Oral | 1-2 hrs | 2-3 hrs | 2.5-3.5 hrs | 30-40 hrs |
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
- Stimulation
- Pain Relief
- Headaches
- Headache
- Nausea
- Jaw tremor
- Body Odor Alteration
- Increased saliva production
- GI peristalsis
- Bradycardia
- Memory Enhancement
- Focus Enhancement
- Wakefulness
- Dream Potentiation
- Mindfulness
- Addiction Suppression
- Enhanced Focus
- Mental Clarity
- Mood Enhancement
- Improved Memory
- Acuity Enhancement
- Bodily Control Enhancement
- Visual Acuity Enhancement
- Appetite Suppression
- Light sensitivity
- Warm facial flushing
- Appetite suppression
- Olfactory Intensification
- Drifting
- Internal hallucination
Helpful Links
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