Chemical Class
Benzodiazepine
Psychoactive Class
Depressant
Pharmacology
DrugBank
Half-life 4 hours
Protein binding 99% bound to plasma proteins.
State Solid
Metabolism Hepatic.
Description
Clotiazepam is a thienodiazepine, not approved for sale in the U.S. or Canada, but has been approved in the U.K. It is a schedule IV drug in Canada.
Mechanism of Action
Clotiazepam acts at the benzodiazepine receptors (BZD). This agonizes the action of GABA, increasing the frequency of opening of the channel chlorinates and penetration of the ions chlorinates through the ionophore. Increase in membrane polarization decreases the probability of discharge of neurons.
Pharmacodynamics
Clotiazepam is a thienodiazepine possessing anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It increases the stage 2 non-rapid eye movement sleep.
Indication
For the treatment of anxiety disorders.
Effect Profile
Curated
Benzodiazepine
4.7
Strong euphoria with low anxiolysis, sedation, and cognitive impairment
Anxiolysis×3
3
Sedation / Relaxation×2
3
Motor / Cognitive Impairment×1
2
Euphoria / Mood Lift×1
10
Based on reports from:
Tolerance & Pharmacokinetics
drugs.wikiTolerance Decay
Full tolerance
3d
Half tolerance
37d
Baseline
~60d