Codeine (also known as 3-Methylmorphine) is a naturally-occurring opioid substance of the morphinan class found in extracts of the poppy, particularly Papaver bracteatum. Members of this group produce effects such as sedation, cough suppression, and euphoria when administered. Codeine is the second most predominant alkaloid in opium (up to three percent).
⚠ Equianalgesic dose ratios are approximations and do not account for
genetic factors, tolerance, incomplete cross-tolerance, or pharmacokinetic variations.
Methadone conversion is especially variable at higher doses.
Always consult a healthcare provider before making any changes to opioid therapy.
Effect Profile
260 reports
Scores (1–10) curated from multiple sources:
Effect keyword matching from PsychonautWiki catalog
Validated against 198 Erowid trip reports
Weighted by importance: core (×3), major (×2), minor (×1)
Build-updevelops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Tolerance Decay
Full tolerance
5dHalf tolerance
3dBaseline
~14d
Opioid tolerance builds rapidly with near-daily use and decays over weeks. Loss of tolerance after short breaks markedly increases overdose risk if returning to prior ‘pour’ sizes. Data are approximate and largely based on general opioid patterns rather than promethazine/codeine–specific studies.