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    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    Cychlorphine Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 1 source
    • 3 ROAs with full dose ladders
    • duration data present
    • 19 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: Cychlorophine, N-propionitrile chlorophine

    Depressant Research-chemical Opioid

    Summary TheDrug.Wiki

    Extremely limited pharmacological data; field samples frequently contain co-contaminants including xylazine or chlorphine. Standard fentanyl test strips yield false-negatives for benzimidazolone opioids. Naloxone may have reduced effectiveness for reversal of toxicity.

    Dose Information TheDrug.Wiki

    ROA Light Common Strong Heavy
    Oral 10-40µg 40-120µg 120-250µg 250µg+
    Insufflated 5-25µg 25-80µg 80-150µg 150µg+
    Intravenous 2-10µg 10-40µg 40-80µg 80µg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Peak Offset After Effects Total
    Oral 30-90 min 3-6 hrs 2-6 hrs 4-8 hrs
    Insufflated 30-90 min 3-6 hrs 2-6 hrs 4-8 hrs
    Intravenous 30-90 min 3-6 hrs 2-6 hrs 4-8 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 7.0
    Strong+ 7/10

    Strong euphoria, itching/nausea, and pain relief with low sedation

    Euphoria / Warmth ×3
    10
    physical euphoria euphoria cognitive euphoria warmth
    Analgesia ×2
    8
    analgesia pain relief
    Sedation / Relaxation ×1
    3
    sedation
    ⚠ Itching / Nausea ×1
    10
    pruritus nausea constipation
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Cychlorphine
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 4d Half tolerance 10d Baseline ~35d

    Empirical timelines extrapolated from general opioid use patterns; specific tolerance kinetics for cychlorphine are unknown.

    Cross-Tolerances

    Opioids (µ-agonists)
    70%

    Effects TheDrug.Wiki

    Positive
    • Analgesia
    • Anxiolysis
    • Physical euphoria
    • Pain relief
    Negative
    • Respiratory depression
    • Pruritus
    • Nausea
    Neutral
    • Sedation
    • Miosis
    • Itchiness
    Positive
    • Euphoria
    • Reduced anxiety
    • Cognitive euphoria
    • Anxiety suppression
    • Wakefulness
    • Motivation enhancement
    Negative
    • Constipation
    • Compulsive redosing
    • Motivation suppression
    • Anxiety
    Positive
    • Warmth
    • Increased music appreciation
    • Increased libido
    Negative
    • Appetite suppression
    • Light sensitivity
    • Disinhibition
    • Dehydration
    Neutral
    • Dulled perception
    • Internal hallucination
    • Warm flush

    Combinations TripSit

    Cross-Check Cychlorphine with another substance

    Cychlorphine's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki