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    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    Cychlorphine Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 3 ROAs with full dose ladders
    • duration data present
    • 19 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: Cychlorophine, N-propionitrile chlorophine

    Depressant Research-chemical Opioid

    Summary dose.wiki

    Extremely limited pharmacological data; field samples frequently contain co-contaminants including xylazine or chlorphine. Standard fentanyl test strips yield false-negatives for benzimidazolone opioids. Naloxone may have reduced effectiveness for reversal of toxicity.

    Dose Information dose.wiki Drugs.Wiki

    Dose basis. The dose figures on this page are not clinical data. They are aggregated from community reports by a secondary source whose own notes state there is no human pharmacokinetic study behind them, and our internal audit flags this substance's dosing as unverifiable. Treat them as a rough orientation, not a safe range. This is a microgram-active opioid: a normal milligram scale cannot weigh a dose of it accurately, and a weighing error here is measured in lethal multiples rather than percentages. Volumetric dosing is the only defensible method, and batch-to-batch potency in the unregulated supply varies enormously. Assume full respiratory depression, keep naloxone to hand, never dose alone, and never combine with benzodiazepines, alcohol or other depressants.

    ROA Light Common Strong Heavy
    Oral 10-40µg 40-120µg 120-250µg 250µg+
    Insufflated 5-25µg 25-80µg 80-150µg 150µg+
    Intravenous 2-10µg 10-40µg 40-80µg 80µg+
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Peak Offset After Effects Total
    Oral 5-15 min 30-90 min 3-6 hrs 2-6 hrs 3.58-7.75 hrs
    Insufflated 5-15 min 30-90 min 3-6 hrs 2-6 hrs 3.58-7.75 hrs
    Intravenous 1-5 min 30-90 min 3-6 hrs 2-6 hrs 3.52-7.58 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 7.0
    Strong+ 7/10

    Strong euphoria, itching/nausea, and pain relief with low sedation

    Euphoria / Warmth ×3
    10
    physical euphoria euphoria cognitive euphoria warmth
    Analgesia ×2
    8
    analgesia pain relief
    Sedation / Relaxation ×1
    3
    sedation
    ⚠ Itching / Nausea ×1
    10
    pruritus nausea constipation
    View methodology →

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track Cychlorphine there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "Cychlorphine (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    Cychlorphine
    Unit
    µg
    Description 
    Cychlorphine
Source: SubstanceSearch (substancesearch.com)

Oral dose (µg): threshold 10 · light 10-40 · common 40-120 · strong 120-250 · heavy 250+
Insufflated dose (µg): threshold 5 · light 5-25 · common 25-80 · strong 80-150 · heavy 150+
Intravenous dose (µg): threshold 2 · light 2-10 · common 10-40 · strong 40-80 · heavy 80+

Oral duration: onset 5-15m · peak 0.5-1.5h · offset 3-6h · total 3.58-7.75h · after-effects 2-6h
Insufflated duration: onset 5-15m · peak 0.5-1.5h · offset 3-6h · total 3.58-7.75h · after-effects 2-6h
Intravenous duration: onset 1-5m · peak 0.5-1.5h · offset 3-6h · total 3.52-7.58h · after-effects 2-6h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 80 µg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 4d Half tolerance 10d Baseline ~35d

    Empirical timelines extrapolated from general opioid use patterns; specific tolerance kinetics for cychlorphine are unknown.

    Cross-Tolerances

    Opioids (µ-agonists)
    70%

    Effects dose.wiki

    Positive
    • Analgesia
    • Anxiolysis
    • Physical euphoria
    • Pain relief
    Negative
    • Respiratory depression
    • Pruritus
    • Nausea
    Neutral
    • Sedation
    • Miosis
    • Itchiness
    Positive
    • Euphoria
    • Reduced anxiety
    • Cognitive euphoria
    • Anxiety suppression
    • Wakefulness
    • Motivation enhancement
    Negative
    • Constipation
    • Compulsive redosing
    • Motivation suppression
    • Anxiety
    Positive
    • Warmth
    • Increased music appreciation
    • Increased libido
    Negative
    • Appetite suppression
    • Light sensitivity
    • Disinhibition
    • Dehydration
    Neutral
    • Dulled perception
    • Internal hallucination
    • Warm flush

    Combinations

    Cross-Check Cychlorphine with another substance

    Cychlorphine's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki