Cychlorphine
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- 29 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 2 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- 29 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: Cychlorophine, N-propionitrile chlorophine
Summary
Extremely limited pharmacological data; field samples frequently contain co-contaminants including xylazine or chlorphine. Standard fentanyl test strips yield false-negatives for benzimidazolone opioids. Naloxone may have reduced effectiveness for reversal of toxicity.
Dose Information
Dose basis. The dose figures on this page are not clinical data. They are aggregated from community reports by a secondary source whose own notes state there is no human pharmacokinetic study behind them, and our internal audit flags this substance's dosing as unverifiable. Treat them as a rough orientation, not a safe range. This is a microgram-active opioid: a normal milligram scale cannot weigh a dose of it accurately, and a weighing error here is measured in lethal multiples rather than percentages. Volumetric dosing is the only defensible method, and batch-to-batch potency in the unregulated supply varies enormously. Assume full respiratory depression, keep naloxone to hand, never dose alone, and never combine with benzodiazepines, alcohol or other depressants.
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 10-40µg | 40-120µg | 120-250µg | 250µg+ |
| Insufflated | 5-25µg | 25-80µg | 80-150µg | 150µg+ |
| Intravenous | 2-10µg | 10-40µg | 40-80µg | 80µg+ |
Sources
Oral
Dose ladder — Drugs.WikiInsufflated
Dose ladder — Drugs.WikiIntravenous
Dose ladder — Drugs.WikiOnset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 5-15 min | 30-90 min | 3-6 hrs | 3.58-7.75 hrs |
| Insufflated | 5-15 min | 30-90 min | 3-6 hrs | 3.58-7.75 hrs |
| Intravenous | 1-5 min | 30-90 min | 3-6 hrs | 3.52-7.58 hrs |
Effect Profile
Scores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong euphoria and pain relief with strong itching/nausea, low sedation
Tolerance
No tolerance chart. Our decay curves for opioids were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.
Opioid tolerance drops fast when you stop, and even a few days off can be enough, so a dose that used to be normal can now stop your breathing. Overdose deaths rise sharply after prison, detox or leaving treatment, and tolerance also falls during a hospital stay. After any break, start with a much smaller amount, try a test dose first, don't use alone, and keep naloxone within reach. Alcohol, benzodiazepines, gabapentinoids and other sedatives make an opioid overdose much more likely.
Sources: FRANK: heroin · National Harm Reduction Coalition · WHO: opioid overdose · Merrall et al. 2010 · Binswanger et al. 2007 · Strang et al. 2003 · FDA 2019: gabapentinoids and breathing
Cross-Tolerances
Effects
Effect glossary — · full glossary
Combinations
Cross-Check Cychlorphine with another substanceHelpful Links
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Cychlorphine there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Cychlorphine Source: SubstanceSearch (substancesearch.com) Oral dose (µg): threshold 10 · light 10-40 · common 40-120 · strong 120-250 · heavy 250+ Insufflated dose (µg): threshold 5 · light 5-25 · common 25-80 · strong 80-150 · heavy 150+ Intravenous dose (µg): threshold 2 · light 2-10 · common 10-40 · strong 40-80 · heavy 80+ Oral duration: onset 5-15m · peak 0.5-1.5h · offset 3-6h · total 3.58-7.75h · after-effects 2-6h Insufflated duration: onset 5-15m · peak 0.5-1.5h · offset 3-6h · total 3.58-7.75h · after-effects 2-6h Intravenous duration: onset 1-5m · peak 0.5-1.5h · offset 3-6h · total 3.52-7.58h · after-effects 2-6h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 80 µg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for Cychlorphine? Let us know. Reports are reviewed by moderators — this is not posted publicly.