Pharmacology
DrugBankDescription
Cyclazodone is a psychomotor stimulant. There is little information about it and it does not appear to have ever been marketed.
Pharmacodynamics
Purported to be a relatively weak triple monoamine releaser, similar to Cocaine (but not nearly as potent).
Toxicity
emoline toxicity has also been associated with choreoathetosis and rhabdomyolysis.
Indication
Intended as a therapeutic agent for ADHD, similar to Pemoline (being a derivative thereof); never marketed.
Receptor Profile
Receptor Actions
Effect Profile
Curated + 4 ReportsStrong euphoria, anxiety/jitters, and focus with moderate stimulation
Tolerance & Pharmacokinetics
drugs.wikiTolerance Decay
Tolerance patterns are extrapolated from stimulant class experience and user reports; high uncertainty. Spacing use ≥48–72 h reduces rapid tolerance build.
Cross-Tolerances
Experience Report Analysis
ErowidDemographics
Gender Distribution
Age Distribution
Reports Over Time
Effect Analysis
ErowidEffects aggregated from 4 experience reports (4 Erowid)
Effect Sentiment Distribution
Confidence Distribution
Positive Effects 3
Adverse Effects 1
Real-World Dose Distribution
62K DosesFrom 8 individual dose entries
Sublingual (n=7)
Legal Status
| Country | Status | Notes |
|---|---|---|
| Germany | Cyclazodone is not a controlled substance under the BtMG ( Narcotics Act ) or the NpSG ( New Psychoactive Substances Act ). | According to §2 AMG ( Medicines Act ) it would fall under the definition of a medicine because it induces pharmacological effect. By a decision of the European Court of Justice, this definition was declared ineffective because it was not compatible with EU law. Cyclazodone can be considered legal. |
| Switzerland | Cyclazodone is not controlled under Buchstabe A, B, C and D. | It could be considered legal. |
| United States | Cyclazodone being an analogue of pemoline , a Schedule IV controlled substance in the US, may fall under Federal Analogue Act, 21 U.S.C. | § 813 when intended for human consumption. |
Harm Reduction
drugs.wiki• Class warning: Pemoline, a close structural relative, was withdrawn in the U.S. for risk of severe liver injury; cyclazodone’s human hepatotoxic risk is unquantified, so repeated or high‑dose use should be treated as potentially hepatotoxic. Discontinue and seek medical care if jaundice, right‑upper‑quadrant pain, dark urine, pale stools, or marked fatigue occur. • Consider baseline and periodic liver function tests (ALT/AST/bilirubin) if using beyond single occasional trials or more than once weekly; avoid if you have known liver disease. • Avoid stacking with hepatotoxins (heavy alcohol, high/repeated acetaminophen, anabolic steroids, isoniazid, high‑dose vitamin A) during the same week of use. • Onset can be variable; some users report very delayed or stepwise onsets and sudden intensity several hours later. Because of this, do not redose for several hours after an initial dose. • Cardiovascular screening and monitoring similar to other stimulants is prudent: avoid if you have uncontrolled hypertension, significant heart disease, or hyperthyroidism; check blood pressure/heart rate during first trials. • MAOIs are contraindicated with sympathomimetic stimulants due to hypertensive crises—do not combine within 14 days of MAOI use. • Combining with other stimulants or high caffeine increases risks of anxiety, tachycardia, hypertension, bruxism, and insomnia; spacing such agents is safer. • Subjective effects are often described as functional stimulation with focus and minimal euphoria; however, some users experience marked anxiety, body load, and dysphoria at doses others find moderate—start low, titrate cautiously. • Prefer oral administration; insufflation appears in anecdotes but offers no safety advantage and may increase adverse effects. • Product authenticity/purity is uncertain in gray markets; reagent references for cyclazodone are sparse. Where possible, use professional GC/MS drug checking; otherwise, avoid multi‑gram purchases and unknown vendors. • Tolerance to stimulation builds with frequent use; spacing use by several days reduces tolerance and cumulative strain on the liver and sleep. • There is no established human half‑life; effects are long enough that late‑day dosing can impair sleep. • Do not combine with decongestants (pseudoephedrine/phenylephrine) or other adrenergics due to additive pressor effects. • Avoid during pregnancy or if trying to conceive; there are no human safety data.
References
Data Sources
Cited References
- Bluelight: Cyclazodone Megathread
- ChemSpider: Cyclazodone Chemical Structure
- Erowid: Cyclazodone Experience Report
- Guidicelli Patent: US3609159A
- Miller (2011): TAAR1 and Monoamine Transporters
- NDEWS: Cyclazodone Web Monitoring Alert
- PubChem: Cyclazodone
- Toxicity Case Report: N-Methyl-Cyclazodone
- Erowid: Cyclazodone Experience Report
- Bluelight: Cyclazodone Discussion
- Bluelight: Cyclazodone Safety Discussion
Drugs.wiki References
- NCBI MedGen: Pemoline withdrawn for life‑threatening hepatic failure
- StatPearls: Amphetamine—MAOI contraindication, cardiovascular and serotonergic cautions
- Cyclazodone Megathread (Bluelight) – dosage ranges, limited data warnings
- Bluelight: Cyclazodone discussion threads (general info, limited human data)
- Reddit r/researchchemicals: ‘Be careful if you try cyclazodone’ (15 mg too stimulating)
- Reddit r/researchchemicals: ‘So I Was Wrong About Cyclazodones’ (delayed onset report)
- Erowid/DrugsData—lab drug checking project overview
- Reddit r/ReagentTesting: no reagent reference data for cyclazodone; DrugsData recommended
- Erowid experience report (user report context)