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    Cyclazodone molecular structure

    Cyclazodone Stats & Data

    Cyclazadone Cyclopropylpemoline
    Psychoactive Class Stimulant
    Half-Life Unknown in humans; functional effects typically 5–8 h with a long tail in some users.

    Pharmacology

    DrugBank
    State Solid

    Description

    Cyclazodone is a psychomotor stimulant. There is little information about it and it does not appear to have ever been marketed.

    Pharmacodynamics

    Purported to be a relatively weak triple monoamine releaser, similar to Cocaine (but not nearly as potent).

    Toxicity

    emoline toxicity has also been associated with choreoathetosis and rhabdomyolysis.

    Indication

    Intended as a therapeutic agent for ADHD, similar to Pemoline (being a derivative thereof); never marketed.

    Receptor Profile

    Receptor Actions

    Agonists
    TAAR1 agonist
    Other
    Dopamine releasing agent
    Norepinephrine releasing agent
    Serotonin releasing agent (low to moderate affinity)

    Effect Profile

    Curated + 4 Reports
    Stimulant 7.4

    Strong euphoria, anxiety/jitters, and focus with moderate stimulation

    Stimulation / Energy×3
    7
    Euphoria / Mood Lift×2
    10
    Focus / Productivity×2
    9
    Anxiety / Jitters×1
    10

    Tolerance & Pharmacokinetics

    drugs.wiki
    Half-Life
    Unknown in humans; functional effects typically 5–8 h with a long tail in some users.
    Addiction Potential
    Psychological dependence possible, as with other dopaminergic stimulants; compulsive redosing appears less common than with amphetamines but is reported. Long‑term dependence liability in humans is not characterized.

    Tolerance Decay

    Full tolerance 2d Half tolerance 3d Baseline ~7d

    Tolerance patterns are extrapolated from stimulant class experience and user reports; high uncertainty. Spacing use ≥48–72 h reduces rapid tolerance build.

    Cross-Tolerances

    Amphetamines
    50% ●○○
    Methylphenidate
    40% ●○○
    Pemoline-class (fenozolone, thozalinone)
    60% ●○○

    Experience Report Analysis

    Erowid
    4 Reports
    2020–2024 Date Range
    4 With Age Data
    5 Effects Detected

    Demographics

    Gender Distribution

    Age Distribution

    Reports Over Time

    Effect Analysis

    Erowid

    Effects aggregated from 4 experience reports (4 Erowid)

    4 Reports
    5 Effects Detected
    3 Positive
    1 Adverse
    1 Neutral

    Effect Sentiment Distribution

    Confidence Distribution

    Positive Effects 3

    Focus Enhancement 100.0% 70%
    Euphoria 75.0% 70%
    Stimulation 75.0% 70%

    Adverse Effects 1

    Anxiety 75.0% 70%

    Real-World Dose Distribution

    62K Doses

    From 8 individual dose entries

    Sublingual (n=7)

    Median: 20.0mg 25th: 15.0mg 75th: 30.0mg 90th: 34.0mg
    mg/kg median: 0.315 mg/kg 75th: 0.472

    Legal Status

    Country Status Notes
    Germany Cyclazodone is not a controlled substance under the BtMG ( Narcotics Act ) or the NpSG ( New Psychoactive Substances Act ). According to §2 AMG ( Medicines Act ) it would fall under the definition of a medicine because it induces pharmacological effect. By a decision of the European Court of Justice, this definition was declared ineffective because it was not compatible with EU law. Cyclazodone can be considered legal.
    Switzerland Cyclazodone is not controlled under Buchstabe A, B, C and D. It could be considered legal.
    United States Cyclazodone being an analogue of pemoline , a Schedule IV controlled substance in the US, may fall under Federal Analogue Act, 21 U.S.C. § 813 when intended for human consumption.

    Harm Reduction

    drugs.wiki

    • Class warning: Pemoline, a close structural relative, was withdrawn in the U.S. for risk of severe liver injury; cyclazodone’s human hepatotoxic risk is unquantified, so repeated or high‑dose use should be treated as potentially hepatotoxic. Discontinue and seek medical care if jaundice, right‑upper‑quadrant pain, dark urine, pale stools, or marked fatigue occur. • Consider baseline and periodic liver function tests (ALT/AST/bilirubin) if using beyond single occasional trials or more than once weekly; avoid if you have known liver disease. • Avoid stacking with hepatotoxins (heavy alcohol, high/repeated acetaminophen, anabolic steroids, isoniazid, high‑dose vitamin A) during the same week of use. • Onset can be variable; some users report very delayed or stepwise onsets and sudden intensity several hours later. Because of this, do not redose for several hours after an initial dose. • Cardiovascular screening and monitoring similar to other stimulants is prudent: avoid if you have uncontrolled hypertension, significant heart disease, or hyperthyroidism; check blood pressure/heart rate during first trials. • MAOIs are contraindicated with sympathomimetic stimulants due to hypertensive crises—do not combine within 14 days of MAOI use. • Combining with other stimulants or high caffeine increases risks of anxiety, tachycardia, hypertension, bruxism, and insomnia; spacing such agents is safer. • Subjective effects are often described as functional stimulation with focus and minimal euphoria; however, some users experience marked anxiety, body load, and dysphoria at doses others find moderate—start low, titrate cautiously. • Prefer oral administration; insufflation appears in anecdotes but offers no safety advantage and may increase adverse effects. • Product authenticity/purity is uncertain in gray markets; reagent references for cyclazodone are sparse. Where possible, use professional GC/MS drug checking; otherwise, avoid multi‑gram purchases and unknown vendors. • Tolerance to stimulation builds with frequent use; spacing use by several days reduces tolerance and cumulative strain on the liver and sleep. • There is no established human half‑life; effects are long enough that late‑day dosing can impair sleep. • Do not combine with decongestants (pseudoephedrine/phenylephrine) or other adrenergics due to additive pressor effects. • Avoid during pregnancy or if trying to conceive; there are no human safety data.

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