Background: Diagnosed ADHD, seem to need a higher dose of every stimulant except Adderall, but can't stand the irritability and anger it causes. Vyvanse is shitty, unpredictable Adderall . Dislike Concerta due to how uneven it releases and the horrid crash.
Cyclazodone
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- toxicity data (PsychonautWiki)
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- toxicity data (PsychonautWiki)
- classified Research-chemical
Aliases: Cyclazadone, Cyclopropylpemoline
Summary
Cyclazodone is a centrally acting stimulant developed in the 1960s, structurally related to pemoline and 4-methylaminorex. It appeared on the research chemical market in 2017 with limited pharmacological data. While animal studies suggest lower cardiotoxicity and hepatotoxicity than amphetamine, the structurally related pemoline was withdrawn due to causing liver damage in children.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 5-15mg | 15-25mg | 25-60mg | 60mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 20-45 min | 30-60 min | 2-4 hrs | 1-2 hrs | 3.83-7.75 hrs |
Effect Profile
4 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Stimulant
7.4
Strong+
7/10
Strong euphoria, anxiety/jitters, and focus with moderate stimulation
Stimulation / Energy
×3
7
stimulation
stamina enhancement
wakefulness
Euphoria / Mood Lift
×2
10
physical euphoria
cognitive euphoria
euphoria
motivation enhancement
Focus / Productivity
×2
9
focus enhancement
analysis enhancement
motivation enhancement
thought acceleration
Anxiety / Jitters
×1
10
anxiety
increased heart rate
teeth grinding
vasoconstriction
sweating
Based on reports from:
Import into PsychonautWiki Journal
The PsychonautWiki Journal app includes Cyclazodone, but its built-in data can be thinner than ours. Importing this file adds a separate "Cyclazodone (Substance Search)" custom substance with our dose ranges, durations and tolerance, so you can log against whichever you prefer.
⬇ Download import file
Import this file as custom substances
and you get "Cyclazodone (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer.
Ranges are harm-reduction guidance, not a prescription.
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute tolerance; longer for full reset
Tolerance Decay
Full tolerance
2d
Half tolerance
7d
Baseline
~14d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Tolerance patterns are extrapolated from stimulant class experience and user reports; high uncertainty. Spacing use ≥48–72 h reduces rapid tolerance build.
Cross-Tolerances
Effects
Aggregated from 4 Erowid experience reports
Positive Effects 3
Focus Enhancement
100.0%
70%
Euphoria
75.0%
70%
Stimulation
75.0%
70%
Adverse Effects 1
Anxiety
75.0%
70%
Community Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 4 reports 1 positive 2 neutral 1 cautionary visit
For the past 8 or 9 months I've been using the functional stimulant Cyclazodone to treat my ADHD, and I must say it's absolutely wonderful. Let's start over. Waaaay over. I was 4 years old when I took my first 5mg Adderall dose. Four. From then on I've had photographic memory.
First and Second Experiences With Cyclazodone male, mid 20s body weight 65 kg past experiences: non-response to amphetamine and methylphenidate On Friday at 17:13, I took 10 mg of cyclazodone (orally). Immediately after administration, resting heart rate was 80 BPM.
Third Experience With Cyclazodone male, mid 20s body weight 65 kg past experiences: non-response to amphetamine and methylphenidate 16:48 - 39 mg cyclazodone (oral route) HR 76 BPM Today was an ordinary working day. I slept poorly (~6 hrs), I felt tired and demotivated all day. Negative thoughts, low self worth.
Cyclazodone's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
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