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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    Cyclazodone

    Aliases: Cyclazadone, Cyclopropylpemoline

    Stimulant Nootropic Research-chemical

    Summary TheDrug.Wiki PsychonautWiki

    Cyclazodone is a centrally acting stimulant developed in the 1960s, structurally related to pemoline and 4-methylaminorex. It appeared on the research chemical market in 2017 with limited pharmacological data. While animal studies suggest lower cardiotoxicity and hepatotoxicity than amphetamine, the structurally related pemoline was withdrawn due to causing liver damage in children.

    Dose Information TheDrug.Wiki PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 5-15mg 15-25mg 25-60mg 60mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects
    Oral 20-45 min 30-60 min 2-4 hrs 1-2 hrs 1-6 hrs

    Effect Profile

    4 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 7.4
    Strong+ 7/10

    Strong euphoria, anxiety/jitters, and focus with moderate stimulation

    Stimulation / Energy ×3
    7
    stimulation stamina enhancement wakefulness
    Euphoria / Mood Lift ×2
    10
    physical euphoria cognitive euphoria euphoria motivation enhancement
    Focus / Productivity ×2
    9
    focus enhancement analysis enhancement motivation enhancement thought acceleration
    ⚠ Anxiety / Jitters ×1
    10
    anxiety increased heart rate teeth grinding vasoconstriction sweating
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Cyclazodone
    View methodology →

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute tolerance; longer for full reset

    Tolerance Decay

    Full tolerance 2d Half tolerance 3d Baseline ~7d

    Tolerance patterns are extrapolated from stimulant class experience and user reports; high uncertainty. Spacing use ≥48–72 h reduces rapid tolerance build.

    Cross-Tolerances

    Amphetamines
    50%
    Methylphenidate
    40%
    Pemoline-class (fenozolone, thozalinone)
    60%

    Effects Erowid

    Aggregated from 4 Erowid experience reports

    Positive Effects 3

    Focus Enhancement 100.0% 70%
    Euphoria 75.0% 70%
    Stimulation 75.0% 70%

    Adverse Effects 1

    Anxiety 75.0% 70%
    Cyclazodone's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki