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    Cyproheptadine Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • PubChem toxicity data
    • dose data not in PW/TripSit (unverifiable)

    Aliases: Reactin, Apeplus, Biohept, Periatin, Periactin

    Depressant

    Summary dose.wiki

    For serotonin syndrome management: administer a 12 mg oral loading dose, then 2 mg every 2 hours until clinical improvement (max 32 mg/24 hours); thereafter give 4-8 mg every 6 hours as needed. Monitor for over-sedation, urinary retention, delirium, and hepatic enzymes in prolonged courses. May interfere with hemostasis and prolong bleeding time.

    Dose Information dose.wiki Drugs.Wiki

    Dose basis. Ranges aligned to therapeutic tablet strengths (4 mg) and typical single-dose sedation reports; do not exceed 32 mg in any 24-hour period without medical oversight. Community reporting + label-style dosing context; not a target for recreation. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Oral 4-8mg 8-12mg 16-20mg 24-32mg
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 30-60 min 1-3 hrs 2-6 hrs 2-4 hrs 24 hrs 5.5-14 hrs

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track Cyproheptadine there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "Cyproheptadine (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    Cyproheptadine
    Unit
    mg
    Description 
    Cyproheptadine
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 2-4 · light 4-8 · common 8-12 · strong 16-20 · heavy 24-32

Oral duration: onset 0.5-1h · come-up 1-3h · peak 2-6h · offset 2-4h · total 5.5-14h · after-effects 24h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 10 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops over 1–4 weeks of regular use
    Reset days to weeks depending on duration of use

    Tolerance Decay

    Half tolerance 3d Baseline ~14d

    Users commonly report tolerance to the sedative effect developing over several days of continuous use and partial reversal over weeks after cessation; robust quantitative data are lacking.

    Effects dose.wiki

    Positive
    • Appetite Stimulation
    • Antipruritic Relief
    • Muscle relaxation
    Negative
    • Dry Mouth
    • Motor Coordination Suppression
    • Increased heart rate
    • Muscle cramps
    • Nausea
    Neutral
    • Sedation
    Positive
    • Relaxation
    • Reduced anxiety
    Negative
    • Drowsiness
    • Cognitive Impairment
    • Delirium
    • Confusion
    • Dysphoria
    • Anxiety
    • Paranoia
    • Dizziness
    Negative
    • Blurred Vision
    Neutral
    • Dulled perception
    • External hallucinations
    • Internal hallucinations
    • Visual and audio distortions
    • Perception of Bodily Heaviness
    • External Hallucination
    • Auditory Hallucination

    Pill Identifiers

    9 known pill identifiers on record — view imprints, colors, shapes, and images
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    Cyproheptadine's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    💊 Pill Identifier 📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki