Cyproheptadine
Aliases: Reactin, Apeplus, Biohept, Periatin, Periactin
Summary
For serotonin syndrome management: administer a 12 mg oral loading dose, then 2 mg every 2 hours until clinical improvement (max 32 mg/24 hours); thereafter give 4-8 mg every 6 hours as needed. Monitor for over-sedation, urinary retention, delirium, and hepatic enzymes in prolonged courses. May interfere with hemostasis and prolong bleeding time.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset |
|---|---|---|---|---|
| Oral | 30-60 min | 1-3 hrs | 2-6 hrs | 2-4 hrs |
Tolerance
Build-up
develops over 1–4 weeks of regular use
Reset
days to weeks depending on duration of use
Effects
Positive
- Appetite Stimulation
- Antipruritic Relief
- Muscle relaxation
Negative
- Dry Mouth
- Motor Coordination Suppression
- Dry mouth
- Increased heart rate
- Muscle cramps
- Nausea
- Sedation
Positive
- Relaxation
- Reduced anxiety
Negative
- Drowsiness
- Cognitive Impairment
- Delirium
- Confusion
- Dysphoria
- Anxiety
- Paranoia
- Dizziness
Negative
- Blurred Vision
- Blurred vision
- Dulled perception
- External hallucinations
- Internal hallucinations
- Visual and audio distortions
- Perception of Bodily Heaviness
- External Hallucination
- Auditory Hallucination
- External hallucination
Pill Identifiers
9
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