Dehydroxyfluorafinil Stats & Data
CNC(=O)CS(=O)C(c1ccc(F)cc1)c1ccc(F)cc1MQZWTCIUDSDFCQ-UHFFFAOYSA-NInteraction Warnings
The neurotoxic effects of MDMA may be increased when combined with other stimulants.
This combination may increase strain on the heart.
Receptor Profile
Receptor Actions
Effect Profile
CuratedStrong focus and anxiety/jitters with mild stimulation, low euphoria
Tolerance & Pharmacokinetics
drugs.wikiTolerance Decay
Patterns extrapolated from modafinil‑class anecdotal use; daily use for 1–2 weeks often blunts effects, with partial reversal after 3–5 days off and near‑baseline after 2–4 weeks. Data quality is anecdotal, individual variability is high.
Cross-Tolerances
Harm Reduction
drugs.wikiName/identity: This compound has been sold as “Modafiendz” and discussed as N‑methyl‑4,4'-difluoromodafinil; there is no peer‑reviewed human PK/toxicology, and marketed products may contain variable or mislabelled actives. User reports range from minimal effects to notable palpitations, highlighting batch inconsistency and possible adulteration or degradation. If the analogue shares modafinil’s liabilities, rare but serious cutaneous reactions (e.g., SJS/TEN/DRESS) are a concern; discontinue immediately at any rash or mucosal symptoms. Modafinil‑like CYP effects (3A4 induction; 2C19 inhibition) can meaningfully alter other drugs (e.g., methadone, diazepam) and potentially reduce effectiveness of some hormonal contraceptives—use extra protection while using and for weeks after, pending more data. Cardiovascular strain (tachycardia, BP elevation) and anxiety are reported; those with heart disease, arrhythmia history, or panic disorders should avoid or use only with medical oversight. Residual wakefulness can impair sleep architecture for 6–12 h after offset; avoid late dosing and plan sleep hygiene. Avoid combining with other stimulants or high caffeine to limit BP/HR spikes and jitteriness. Do not snort or inject: modafinil‑class compounds are poorly water soluble and not formulated for non‑oral routes; non‑oral use increases harm without added benefit. Due to frequent mislabeling in the unregulated market, consider drug checking where available; basic reagents are not definitive for this class, but MS‑based services can confirm composition. Until human data exist, treat all dosing guidance as provisional and titrate cautiously.
References
Data Sources
Cited References
- BenchChem listing (CAS 1613222-54-0)
- Bluelight: Legal high similar to speed (UK)
- Bluelight: N-Methyl-4,4-Difluoro-Modafinil
- Cayman Chemical product information PDF
- Cayman Chemical product page
- Drug Users Bible - Modafiendz
- Drugs.com - Caffeine × Modafinil interaction
- Drugs.com - Modafinil interactions list
- PsychonautWiki: N-Methylbisfluoromodafinil
- PubMed: Modafinil half-life study
- UK Psychoactive Substances Act 2016
- Wiley - Thermal degradation of modafinil analogs (DOI)
- ZeptoMetrix Modafiendz product page
- Reddit: / r/Nootropics – New eugeroic Modafiendz
- Reddit: / r/researchchemicals – Dose comparison
Drugs.wiki References
- Bluelight – N‑Methyl‑4,4‑difluoro‑Modafinil (Modafiendz) discussion incl. naming and user reports (palpitations, variable effects)
- Drug Users Bible – Modafiendz (Dehydroxyfluorafinil) user experience and indicative dose bands
- Drugs‑Forum wiki – Modafinil: serious rash warnings; CYP3A4 induction; interaction considerations
- Bluelight – That Wacky Modafinil (mechanistic notes; low abuse liability; orexin/histamine involvement)
- Bluelight – How does modafinil work? (community synthesis; CYP3A4 induction noted)
- Reddit – Modafinil and CYP2C19/3A4 discussion re diazepam/propranolol (illustrates directionality and unpredictability)
- Toronto’s Drug Checking Service – About (availability and value of MS‑based checking for unregulated products)