Delorazepam
Aliases: En, Dadumir, Nordiclazepam, Chlordesmethyldiazepam
Categories
Summary
Extremely long elimination half-life (60-140 hours) means appreciable plasma levels can persist for 5-7 days after a single dose, and longer with repeated dosing. Accumulation is a major risk factor for next-day psychomotor impairment and respiratory depression when combined with other depressants. Active metabolite of diclazepam and cloxazolam; users may feel its effects even when taking those prodrugs. Because it is potent (approximately 10 times more potent than diazepam by weight) and long-acting, start with the low end of the dosing range, especially in naive or respiratory-compromised individuals. Oral bioavailability is approximately 77-87 percent; food has little effect.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 0.25-0.5mg | 0.5-1.5mg | 1.5-2mg | 2-3mg+ |
| Sublingual | 0.25-0.5mg | 0.5-1.5mg | 1.5-2mg | 2-3mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Oral | 30-90 min | 0.5-2 hrs | 2-6 hrs | 6-18 hrs | 72 hrs | 720-0 min |
| Sublingual | 30-90 min | 30-90 min | 2-6 hrs | 6-18 hrs | 72 hrs | 720-0 min |
Tolerance
Build-up
develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
Reset
weeks to months depending on half-life and duration of use; taper recommended
Effects
Positive
- Muscle relaxation
- Seizure suppression
- Physical euphoria
- Anxiolytic
- Muscle Relaxant
Negative
- Sedation
- Residual sleepiness
- Sedative
- Dystaxia
- Hypnotic
Positive
- Anxiety suppression
- Cognitive euphoria
Negative
- Memory suppression
- Amnesia
- Emotion suppression
- Thought deceleration
- Motor control loss
- Dizziness
- Delusions of sobriety
- Rebound anxiety
Positive
- Increased libido
- Appetite enhancement
Negative
- Disinhibition
- Decreased Libido
- Acuity Suppression
- Acuity suppression
- Double vision
- Visual acuity suppression
- Dulled perception
- Perception of bodily heaviness