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    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Benzodiazepines can cause physical dependence with regular use. Withdrawal can be life-threatening. Never combine with opioids or alcohol.

    Desmethylflunitrazepam Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 17 combo interactions documented
    • classified Research-chemical

    Aliases: Fonazepam, Ro05-4435, Norflunitrazepam, N-desmethylflunitrazepam

    Depressant Research-chemical Benzodiazepine

    Summary dose.wiki TripSit

    Extremely potent benzodiazepine requiring accurate milligram-scale measurement. Produces profound anterograde amnesia and severe motor impairment; users commonly experience complete blackouts at doses above 2 mg. Long elimination half-life leads to significant next-day impairment and cumulative effects with repeated dosing.

    Dose Information dose.wiki TripSit

    ROA Light Common Strong Heavy
    Oral 0.5-1mg 1-2mg 2-4mg 4mg+
    Sublingual 0.5-1mg 1-2mg 2-4mg 4mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki TripSit

    ROA Onset Peak Offset After Effects Total
    Oral 20-60 min 2-4 hrs 6-10 hrs 12-24 hrs 5-10 hrs
    Sublingual 15-45 min 2-4 hrs 6-10 hrs 12-24 hrs 5-10 hrs
    Insufflated 10-30 min 2-4 hrs 6-10 hrs 12-24 hrs 5-10 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Benzodiazepine 7.1
    Strong+ 7/10

    Strong anxiolysis, cognitive impairment, and euphoria with mild sedation

    Anxiolysis ×3
    10
    anxiety suppression anxiolytic muscle relaxation muscle relaxant emotion suppression
    Sedation / Relaxation ×2
    5
    sedation muscle relaxation
    ⚠ Motor / Cognitive Impairment ×1
    10
    motor control loss amnesia memory suppression delusions of sobriety double vision
    Euphoria / Mood Lift ×1
    10
    cognitive euphoria physical euphoria disinhibition
    View methodology →

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track Desmethylflunitrazepam there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "Desmethylflunitrazepam (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    Desmethylflunitrazepam
    Unit
    mg
    Description 
    Desmethylflunitrazepam
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): light 0.5-1 · common 1-2 · strong 2-4 · heavy 4+
Sublingual dose (mg): threshold 0.2 · light 0.5-1 · common 1-2 · strong 2-4 · heavy 4+
Insufflated dose: threshold 0.2

Oral duration: onset 0.33-1h · peak 2-4h · offset 6-10h · total 5-10h · after-effects 12-24h
Sublingual duration: onset 15-45m · peak 2-4h · offset 6-10h · total 5-10h · after-effects 12-24h
Insufflated duration: onset 10-30m · peak 2-4h · offset 6-10h · total 5-10h · after-effects 12-24h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 1.5 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
    Reset weeks to months depending on half-life and duration of use; taper recommended

    Tolerance Decay

    Full tolerance 14d Half tolerance 14d Baseline ~60d

    Benzodiazepine tolerance builds with repeated daily use and decays slowly over weeks after cessation; precise kinetics for desmethylflunitrazepam are not established. Cross‑tolerance across benzodiazepines is strong; partial cross‑tolerance exists to non‑benzodiazepine GABA-A hypnotics (Z‑drugs) and alcohol. Numbers above are heuristic markers for planning conservative spacing of doses and extended tapers, not pharmacokinetic half‑lives of the drug. Evidence base: clinical literature on benzodiazepine withdrawal/tolerance patterns and general BZD pharmacology.

    Cross-Tolerances

    Other benzodiazepines
    100%
    Z-drugs
    50%
    Alcohol
    30%

    Effects dose.wiki

    Positive
    • Muscle relaxation
    • Physical euphoria
    • Anxiolytic
    • Muscle Relaxant
    Negative
    • Respiratory depression
    • Motor impairment
    Neutral
    • Sedation
    • Sedative
    • Dystaxia
    • Hypnotic
    Positive
    • Anxiety suppression
    • Cognitive euphoria
    Negative
    • Amnesia
    • Motor control loss
    • Thought deceleration
    • Emotion suppression
    • Delusions of sobriety
    • Compulsive redosing
    • Dizziness
    • Memory suppression
    Positive
    • Increased libido
    • Appetite enhancement
    Negative
    • Disinhibition
    • Acuity suppression
    • Decreased Libido
    • Visual acuity suppression
    • Double vision
    Neutral
    • Dulled perception
    • Perception of bodily heaviness

    Combinations TripSit

    Cross-Check Desmethylflunitrazepam with another substance

    Desmethylflunitrazepam's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

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