Home
    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Benzodiazepines can cause physical dependence with regular use. Withdrawal can be life-threatening. Never combine with opioids or alcohol.

    Desmethylflunitrazepam

    Aliases: Fonazepam, Ro05-4435, Norflunitrazepam, N-desmethylflunitrazepam

    Depressant Research-chemical Benzodiazepine

    Summary TheDrug.Wiki TripSit

    Extremely potent benzodiazepine requiring accurate milligram-scale measurement. Produces profound anterograde amnesia and severe motor impairment; users commonly experience complete blackouts at doses above 2 mg. Long elimination half-life leads to significant next-day impairment and cumulative effects with repeated dosing.

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Oral 0.5-1mg 1-2mg 2-4mg 4mg+
    Sublingual 0.5-1mg 1-2mg 2-4mg 4mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Peak Offset After Effects Total
    Oral 20-60 min 2-4 hrs 6-10 hrs 12-24 hrs 8.3-15 hrs
    Sublingual 15-45 min 2-4 hrs 6-10 hrs 12-24 hrs 8.2-14.8 hrs
    Insufflated 10-30 min 2-4 hrs 6-10 hrs 12-24 hrs 8.2-14.5 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Benzodiazepine 7.1
    Strong+ 7/10

    Strong anxiolysis, cognitive impairment, and euphoria with mild sedation

    Anxiolysis ×3
    10
    anxiety suppression anxiolytic muscle relaxation muscle relaxant emotion suppression
    Sedation / Relaxation ×2
    5
    sedation muscle relaxation
    ⚠ Motor / Cognitive Impairment ×1
    10
    motor control loss amnesia memory suppression delusions of sobriety double vision
    Euphoria / Mood Lift ×1
    10
    cognitive euphoria physical euphoria disinhibition
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Desmethylflunitrazepam
    View methodology →

    Tolerance

    Build-up develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
    Reset weeks to months depending on half-life and duration of use; taper recommended

    Tolerance Decay

    Full tolerance 14d Half tolerance 7d Baseline ~21d

    Benzodiazepine tolerance builds with repeated daily use and decays slowly over weeks after cessation; precise kinetics for desmethylflunitrazepam are not established. Cross‑tolerance across benzodiazepines is strong; partial cross‑tolerance exists to non‑benzodiazepine GABA-A hypnotics (Z‑drugs) and alcohol. Numbers above are heuristic markers for planning conservative spacing of doses and extended tapers, not pharmacokinetic half‑lives of the drug. Evidence base: clinical literature on benzodiazepine withdrawal/tolerance patterns and general BZD pharmacology.

    Cross-Tolerances

    Other benzodiazepines
    100%
    Z-drugs
    50%
    Alcohol
    30%

    Effects TheDrug.Wiki

    Positive
    • Muscle relaxation
    • Physical euphoria
    • Anxiolytic
    • Muscle Relaxant
    Negative
    • Respiratory depression
    • Motor impairment
    Neutral
    • Sedation
    • Sedative
    • Dystaxia
    • Hypnotic
    Positive
    • Anxiety suppression
    • Cognitive euphoria
    Negative
    • Amnesia
    • Motor control loss
    • Thought deceleration
    • Emotion suppression
    • Delusions of sobriety
    • Compulsive redosing
    • Dizziness
    • Memory suppression
    Positive
    • Increased libido
    • Appetite enhancement
    Negative
    • Disinhibition
    • Acuity suppression
    • Decreased Libido
    • Acuity Suppression
    • Visual acuity suppression
    • Double vision
    Neutral
    • Dulled perception
    • Perception of bodily heaviness

    Combinations TripSit

    Desmethylflunitrazepam's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 TripSit 📖 PsychonautWiki