Desmethylflunitrazepam
Aliases: Fonazepam, Ro05-4435, Norflunitrazepam, N-desmethylflunitrazepam
Categories
Summary
Extremely potent benzodiazepine requiring accurate milligram-scale measurement. Produces profound anterograde amnesia and severe motor impairment; users commonly experience complete blackouts at doses above 2 mg. Long elimination half-life leads to significant next-day impairment and cumulative effects with repeated dosing. Active metabolite of flunitrazepam; legal status varies by jurisdiction. Sudden cessation after regular use can precipitate life-threatening withdrawal seizures; always taper gradually under medical supervision.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 0.5-1mg | 1-2mg | 2-4mg | 4mg+ |
| Sublingual | 0.5-1mg | 1-2mg | 2-4mg | 4mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|
| Oral | 20-60 min | 2-4 hrs | 6-10 hrs | 12-24 hrs | 300-0 min |
| Sublingual | 15-45 min | 2-4 hrs | 6-10 hrs | 12-24 hrs | 300-0 min |
| Insufflated | 10-30 min | 2-4 hrs | 6-10 hrs | 12-24 hrs | 300-0 min |
Tolerance
Build-up
develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
Reset
weeks to months depending on half-life and duration of use; taper recommended
Effects
Positive
- Muscle relaxation
- Physical euphoria
- Anxiolytic
- Muscle Relaxant
Negative
- Respiratory depression
- Motor impairment
- Sedation
- Sedative
- Dystaxia
- Hypnotic
Positive
- Anxiety suppression
- Cognitive euphoria
Negative
- Amnesia
- Motor control loss
- Thought deceleration
- Emotion suppression
- Delusions of sobriety
- Compulsive redosing
- Dizziness
- Memory suppression
Positive
- Increased libido
- Appetite enhancement
Negative
- Disinhibition
- Acuity suppression
- Decreased Libido
- Acuity Suppression
- Visual acuity suppression
- Double vision
- Dulled perception
- Perception of bodily heaviness