Home
    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    Diclofensine Limited data
    Limited data
    Sparse data. Doses and effects may be unreliable or untested.
    • 1 source
    • partial dose data
    • duration data present
    • classified Tentative
    • classified Research-chemical

    Aliases: Ro8-4650

    Stimulant Research-chemical

    Summary TripSit

    A triple monoamine reuptake inhibitor developed by Hoffman-LaRoche in the 1970s as an antidepressant but discontinued, probably due to high abuse potential. Has not become popular as a recreational drug at this time. Acts as an SNDRI, mostly inhibits dopamine and noradrenaline.

    Dose Information TripSit

    ROA Light Common Strong Heavy
    Oral 30-40mg 40-60mg - 60-80mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TripSit

    ROA Peak Total
    Oral 4-6 hrs 4-6 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 3.8
    Moderate 4/10

    Strong anxiety/jitters with moderate stimulation and euphoria

    Stimulation / Energy ×3
    6
    stimulation wakefulness alertness enhancement
    Euphoria / Mood Lift ×2
    6
    euphoria cognitive euphoria
    Focus / Productivity ×2
    0
    ⚠ Anxiety / Jitters ×1
    10
    anxiety restlessness increased heart rate vasoconstriction
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Diclofensine
    View methodology →

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute tolerance; longer for full reset

    Tolerance Decay

    Full tolerance 1d Half tolerance 10d Baseline ~18d

    Effects

    Positive
    • Stimulation
    • Mental/physical stimulation
    Negative
    • Increased heart rate
    • Insomnia
    • Pupil dilation
    • Nausea
    • Vasoconstriction
    • Restlessness
    Neutral
    • Sedation
    • Decreased appetite
    Positive
    • Alertness enhancement
    • Euphoria
    • Cognitive euphoria
    • Wakefulness
    • Empathy
    Negative
    • Anxiety
    • Confusion
    • Compulsive redosing
    Neutral
    • Talkativeness
    • Time distortion
    Positive
    • Increased music appreciation
    • Color enhancement
    • Tactile enhancement
    • Brightened colour
    Negative
    • Light sensitivity
    • Disinhibition
    • Appetite suppression
    • Dehydration
    Neutral
    • Dulled perception
    • Drifting
    Diclofensine's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 TripSit 📖 PsychonautWiki