Diclofensine
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 1 source
- partial dose data
- duration data present
- classified Tentative
- classified Research-chemical
- 1 source
- partial dose data
- duration data present
- classified Tentative
- classified Research-chemical
Aliases: Ro8-4650
Summary
A triple monoamine reuptake inhibitor developed by Hoffman-LaRoche in the 1970s as an antidepressant but discontinued, probably due to high abuse potential. Has not become popular as a recreational drug at this time. Acts as an SNDRI, mostly inhibits dopamine and noradrenaline.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 30-40mg | 40-60mg | - | 60-80mg+ |
Onset, Duration & After-effects
| ROA | Peak | Total |
|---|---|---|
| Oral | 4-6 hrs | 4-6 hrs |
Effect Profile
class estimateScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- No reports exist for this substance. Its effect list is the one shared by 1 other substance of the same class, so the scores below describe the class, not this compound.
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong anxiety/jitters with moderate stimulation and euphoria
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Diclofensine there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Diclofensine Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 12-15 · light 30-40 · common 40-60 · heavy 60-80+ Oral duration: peak 4-6h · total 4-6h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 50 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
- Stimulation
- Mental/physical stimulation
- Increased heart rate
- Insomnia
- Pupil dilation
- Nausea
- Vasoconstriction
- Restlessness
- Sedation
- Decreased appetite
- Alertness enhancement
- Euphoria
- Cognitive euphoria
- Wakefulness
- Empathy
- Anxiety
- Confusion
- Compulsive redosing
- Talkativeness
- Time distortion
- Increased music appreciation
- Color enhancement
- Tactile enhancement
- Brightened colour
- Light sensitivity
- Disinhibition
- Appetite suppression
- Dehydration
- Dulled perception
- Drifting
Helpful Links
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