Summary
DMNPC is a piperidine-based stimulant with binding affinities of approximately 7.6 nM at SERT, 21 nM at DAT, and 34 nM at NET, making it roughly 2.5 times more potent than cocaine at DAT while retaining SSRI-level SERT affinity. The compound blocks voltage-gated sodium channels similar to cocaine, producing local anesthesia and potential cardiac conduction effects. Users report severe mucosal irritation with intranasal use and caustic effects when administered intravenously. Oral administration provides cleaner effects with less vascular strain. Due to its recent emergence in late 2024, pharmacokinetic data is limited and reagent testing plus fentanyl screening is essential.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 15-30 min | 15-30 min | 30-90 min | 1-2 hrs | 1-6 hrs |
| Insufflated | 5-10 min | 10-20 min | 30-90 min | 1-2 hrs | 1-6 hrs |
| Intravenous | 1-5 min | 5-10 min | 10-45 min | 1-2 hrs | 1-6 hrs |
| Vaporized / Smoked | 1-5 min | 5-10 min | 10-45 min | 1-2 hrs | 1-6 hrs |
| Rectal | 10-20 min | 15-30 min | 30-90 min | 1-2 hrs | 1-6 hrs |
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute; 1–3 weeks for full reset
Effects
Positive
- Stimulation
- Physical euphoria
- Pain relief
Negative
- Pupil dilation
- Vasoconstriction
- Increased heart rate
- Respiratory depression
- Nausea
- Itchiness
- Sedation
Positive
- Cognitive euphoria
- Focus enhancement
- Sociability enhancement
- Motivation enhancement
- Wakefulness
Negative
- Compulsive redosing
- Anxiety
- Constipation
- Cognitive fatigue
- Time distortion
Positive
- Tactile enhancement
- Color enhancement
- Increased music appreciation
Negative
- Appetite suppression
- Light sensitivity
- Disinhibition
- Dulled perception
- Increased sexuality
- Visual and auditory hallucinations
- Drifting