First Trial, Surprisingly Potent by Xorkoth I'm a man who loves and is fascinated by the DOX class of substances, the 2,5-dimethoxy substituted psychedelic amphetamines.
DOIP
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- classified Tentative
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- classified Tentative
- classified Research-chemical
Aliases: 2,5-dimethoxy-4-isopropylamphetamine
Summary
A rare psychedelic ampthetamine of the same class as the likes of DOM. Is a quite powerful and potent psychedelic that has very strong amphetamine effects. Not for the faint of heart.
Perspectives
“This drug primarily manifested as bodyload, just an intense twisting piercing nausea, urinary retention, bruxism, tremors, and general discomfort and malaise. The headspace was just on threshold- there definitely was something psychedelic there, but it was furtive and elusive, it seemed just over the border from being a regular stimulant.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 800-1500ug | 1.5-3mg | 3mg+ | - |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Total |
|---|---|---|---|
| Oral | 0.75-2 hrs | 18-30 hrs | 18-30 hrs |
Effect Profile
4 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
3.1
Light+
3/10
Moderate body load with mild visuals, low headspace
Visual Intensity
×3
5
color enhancement
drifting
brightened colour
Headspace Depth
×3
2
time distortion
confusion
Auditory Effects
×1
0
Body Load / Somatic Effects
×1
6
nausea
vasoconstriction
increased heart rate
Stimulant
3.8
Moderate
4/10
Strong anxiety/jitters with moderate stimulation and euphoria
Stimulation / Energy
×3
6
stimulation
wakefulness
alertness enhancement
Euphoria / Mood Lift
×2
6
euphoria
cognitive euphoria
Focus / Productivity
×2
0
Anxiety / Jitters
×1
10
anxiety
restlessness
increased heart rate
vasoconstriction
Based on reports from:
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Name
DOIP
Unit
µg
Description
DOIP Source: SubstanceSearch (substancesearch.com) Oral dose (µg): threshold 800ug · light 800-1500ug · common 1.5-3mg · strong 3mg+ Oral duration: onset 0.75-2h · peak 18-30h · total 18-30h · after-effects 1-48h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 2250 µg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Build-up
develops rapidly after a single use
Reset
7–14 days for baseline
Tolerance Decay
Full tolerance
1h
Half tolerance
10d
Baseline
~14d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
Aggregated from 4 Erowid experience reports
Positive Effects 3
Stimulation
100.0%
70%
Euphoria
75.0%
70%
Focus Enhancement
75.0%
70%
Adverse Effects 0
Combinations
Cross-Check DOIP with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 3 reports 2 positive 1 neutral visit
1-4-2019 - DOiP, 2nd trial: 12mg at home halfway through work on a Friday 1:12pm (T+0:00) - Ingested 12mg in 2.4mL of vodka (5mg/mL). Taste was bitter, not too strong. When I use 1mg/mL solutions with DOXs, I can't taste anything but the alcohol.
[This report originally appeared as handwritten notes in the Shulgin Lab Book 3 , PDF page 395] - 1.0mg 10:23AM=[0:00] ATS 11/6/80 n.e. whatsoever. - 2.0mg 1:25PM=[0:00] ATS 11/9/80 n.e. ± 4.0mg 1:17PM=[0:00] ATS 11/11/80 [0:35] alert? [1:00] ±? threshold. [2:30] nothing.
Bluelight 4 threads 4 neutral visit
First Trial, Surprisingly Potent by Xorkoth I'm a man who loves and is fascinated by the DOX class of substances, the 2,5-dimethoxy substituted psychedelic amphetamines.
1-4-2019 - DOiP, 2nd trial: 12mg at home halfway through work on a Friday 1:12pm (T+0:00) - Ingested 12mg in 2.4mL of vodka (5mg/mL). Taste was bitter, not too strong. When I use 1mg/mL solutions with DOXs, I can't taste anything but the alcohol.
After about a 4 week break from psychedelics, I decided to jump back in. There was some nervous energy as my last trip wasn’t very fun and was mostly comprised of worrying vibes, I had a feeling I had maybe overdone it in the last year or so.
Age: 25 Weight: 130 lbs Dosage: 5 mg oral in solution Setting: My house Preface: DOiP (also known as DOiPr) is another fairly logical direction to go when developing psychedelic phenethylamines.
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