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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

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    • 2 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 19 combo interactions documented
    • classified Tentative
    • classified Research-chemical

    Aliases: 2,5-dimethoxy-4-propylamphetamine

    Psychedelic Stimulant Research-chemical

    Summary TripSit

    A rare psychedelic ampthetamine of the same class as the likes of DOM. Is a quite powerful and potent psychedelic that has very strong amphetamine effects. Not for the faint of heart.

    Perspectives

    “This drug primarily manifested as bodyload—intense twisting piercing nausea, urinary retention, bruxism, tremors, and general discomfort. The headspace was just on threshold; there were absolutely no visual or sensory effects to note.”

    Dose Information TripSit

    ROA Light Common Strong Heavy
    Oral 800-1500ug 1.5-3mg 3mg 3mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TripSit

    ROA Onset Peak After Effects Total
    Oral 0.75-2 hrs 18-30 hrs 1-48 hrs 18-30 hrs

    Effect Profile

    4 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 3.1
    Light+ 3/10

    Moderate body load with mild visuals, low headspace

    Visual Intensity ×3
    5
    color enhancement drifting brightened colour
    Headspace Depth ×3
    2
    time distortion confusion
    Auditory Effects ×1
    0
    ⚠ Body Load / Somatic Effects ×1
    6
    nausea vasoconstriction increased heart rate
    Stimulant 3.8
    Moderate 4/10

    Strong anxiety/jitters with moderate stimulation and euphoria

    Stimulation / Energy ×3
    6
    stimulation wakefulness alertness enhancement
    Euphoria / Mood Lift ×2
    6
    euphoria cognitive euphoria
    Focus / Productivity ×2
    0
    ⚠ Anxiety / Jitters ×1
    10
    anxiety restlessness increased heart rate vasoconstriction
    Based on reports from:
    Erowid Experience Reports PsychonautWiki DOIP
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Effects Erowid

    Aggregated from 4 Erowid experience reports

    Positive Effects 3

    Stimulation 100.0% 70%
    Euphoria 75.0% 70%
    Focus Enhancement 75.0% 70%

    Adverse Effects 0

    Combinations TripSit

    Cross-Check DOIP with another substance

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.

    Erowid 3 reports 3 neutral visit
    First Trial Surprisingly Potent neutral exp #109477

    First Trial, Surprisingly Potent by Xorkoth I'm a man who loves and is fascinated by the DOX class of substances, the 2,5-dimethoxy substituted psychedelic amphetamines.

    Xorkoth · 200 mg / 2 bumps / 5 mg oral / smoked
    Difficult Yet Promising neutral exp #112781

    1-4-2019 - DOiP, 2nd trial: 12mg at home halfway through work on a Friday 1:12pm (T+0:00) - Ingested 12mg in 2.4mL of vodka (5mg/mL). Taste was bitter, not too strong. When I use 1mg/mL solutions with DOXs, I can't taste anything but the alcohol.

    Xorkoth · DOiP · 12 mg oral / 2.4 ml oral / 1 hit smoked / 1 mg oral
    Kid Myself Into Some Awareness? neutral exp #109713

    [This report originally appeared as handwritten notes in the Shulgin Lab Book 3 , PDF page 395] - 1.0mg 10:23AM=[0:00] ATS 11/6/80 n.e. whatsoever. - 2.0mg 1:25PM=[0:00] ATS 11/9/80 n.e. ± 4.0mg 1:17PM=[0:00] ATS 11/11/80 [0:35] alert? [1:00] ±? threshold. [2:30] nothing.

    Alexander Shulgin
    Bluelight 4 threads 3 neutral 1 cautionary visit
    Doip 5mg Orally First Time Surprisingly Potent neutral

    First Trial, Surprisingly Potent by Xorkoth ​ I'm a man who loves and is fascinated by the DOX class of substances, the 2,5-dimethoxy substituted psychedelic amphetamines.

    scraped 2026-03-14
    Doip 12mg Orally 2nd Time Difficult Yet Promising neutral

    1-4-2019 - DOiP, 2nd trial: 12mg at home halfway through work on a Friday ​ 1:12pm (T+0:00) - Ingested 12mg in 2.4mL of vodka (5mg/mL). Taste was bitter, not too strong. When I use 1mg/mL solutions with DOXs, I can't taste anything but the alcohol.

    scraped 2026-03-14
    Doip First Time 20mg Excited Energy neutral

    After about a 4 week break from psychedelics, I decided to jump back in. There was some nervous energy as my last trip wasn’t very fun and was mostly comprised of worrying vibes, I had a feeling I had maybe overdone it in the last year or so.

    scraped 2026-03-14
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    Helpful Links

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