DOM Stats & Data
[Cl-].COc1cc(CC(C)N)c(OC)cc1C.[H+]IPIMRNFGYPQKAM-UHFFFAOYSA-NPharmacology
DrugBankDescription
A psychedelic phenyl isopropylamine derivative, commonly called DOM, whose mood-altering effects and mechanism of action may be similar to those of LSD.
Receptor Profile
Receptor Actions
History & Culture
1963–1964
DOM was first synthesized by Alexander Shulgin in 1963. The initial step of the synthesis was performed by his then fifteen-year-old son Theodore "Ted" Shulgin at Dow Chemical Company on June 22, 1963, during a brief period when the younger Shulgin had developed an interest in chemistry. Alexander Shulgin completed the synthesis on November 30, 1963. The compound was initially assigned the code name K-61,082, with "DOM" itself being an acronym derived from the code name "des-oxy-methyl" that Shulgin coined for the substance. Shulgin first discovered the effects of DOM on January 4, 1964, when he ingested a 1 mg dose orally. The hallucinogenic properties of the compound were subsequently confirmed on February 3, 1964, when Shulgin's colleague Thornton W. Sargent ingested 2.3 mg and experienced its full psychedelic effects.
1967–present
In mid-1967, DOM appeared on the black market in the Haight-Ashbury district of San Francisco during the height of the counterculture movement. Tablets containing 20 mg, and later 10 mg, of DOM were distributed widely under the name "STP," which was said to stand for "Serenity, Tranquility, and Peace," though alternative interpretations such as "Super Terrific Psychedelic" and "Stop The Police" also circulated. The name was actually borrowed from a motor oil additive that bore no chemical relation to the drug. These tablets were manufactured by underground chemists Owsley Stanley and Tim Scully. This distribution proved disastrous for several reasons. The tablets contained excessively high doses of the compound, and DOM's slow onset of action created particular problems for users accustomed to LSD. While LSD typically produces noticeable effects within fifteen to twenty minutes, DOM may only show initial effects at the half-hour mark, with full intensity not reached until approximately two hours after ingestion. Many users, expecting the rapid onset they knew from LSD and observing little activity after thirty minutes, assumed the dose was weak and consumed one or two additional tablets. This resulted in numerous hospitalizations, with treatment further complicated by the fact that medical personnel were initially unaware that the tablets called "STP" contained DOM. The negative publicity and health emergencies caused the supply of DOM to fade thereafter.
Despite the troubled circumstances of its initial distribution, DOM holds a significant place in psychedelic history. Shulgin later documented the compound in his book PiHKAL and included it among his "magical half-dozen," a personal selection of the phenethylamine compounds he considered most important. This group comprises mescaline, DOM, 2C-B, 2C-E, 2C-T-2, and 2C-T-7, with DOM being one of the five that Shulgin himself developed and synthesized. There are reports that low doses of DOM were used as a stimulant by members of the Grateful Dead, which may represent one of the earliest documented instances of psychedelic microdosing.
Subjective Effect Notes
physical: The physical effects of DOM can be broken down into several components which progressively intensify proportional to dosage.
cognitive: The cognitive effects of DOM are described by many as a combination of extreme mental stimulation and a powerful enhancement of a person's current mental state.
Effect Profile
Curated + 67 ReportsStrong visuals, body load, headspace, and auditory effects
Strong stimulation and anxiety/jitters with moderate euphoria and focus
Tolerance & Pharmacokinetics
drugs.wikiTolerance Decay
Acute tolerance rises rapidly after a single dose and can persist for days; functional tolerance commonly makes redosing ineffective and mostly prolongs duration. Cross-tolerance with other classic serotonergic psychedelics is expected. Data are primarily from community reports and general psychedelic pharmacology rather than controlled trials.
Cross-Tolerances
Demographics
Gender Distribution
Age Distribution
Reports Over Time
Effect Analysis
Erowid + BluelightEffects aggregated from 67 experience reports (54 Erowid + 13 Bluelight)
Effect Sentiment Distribution
Confidence Distribution
Positive Effects 36
Adverse Effects 42
Dose-Response Correlation
How effect frequency changes across dose levels
View data table
| Effect | Strong (n=12) | Heavy (n=10) |
|---|---|---|
| Visual Distortions | 91.7% | 70.0% |
| Color Enhancement | 83.3% | 60.0% |
| Stimulation | 75.0% | 80.0% |
| Music Enhancement | 66.7% | 70.0% |
| Euphoria | 66.7% | 40.0% |
| Anxiety | 66.7% | 30.0% |
| Empathy | 58.3% | 20.0% |
| Confusion | 33.3% | 50.0% |
| Tactile Enhancement | 41.7% | 20.0% |
| Nausea | 41.7% | 40.0% |
| Focus Enhancement | 33.3% | 40.0% |
| Auditory Effects | 25.0% | 40.0% |
| Sedation | 33.3% | 30.0% |
| Closed-Eye Visuals | 33.3% | 20.0% |
| Open-Eye Visuals | 33.3% | 30.0% |
Dose–Effect Mapping
Experience ReportsHow reported effects shift across dose tiers, based on 54 experience reports.
Limited tier coverage — most reports fall within the Strong / Heavy range. Effects at other dose levels may not be represented.
| Effect | Strong (n=12) | Heavy (n=10) | |
|---|---|---|---|
| visual distortions | ↓ | ||
| color enhancement | ↓ | ||
| stimulation | → | ||
| music enhancement | → | ||
| euphoria | ↓ | ||
| anxiety | ↓ | ||
| empathy | ↓ | ||
| confusion | ↑ | ||
| tactile enhancement | ↓ | ||
| nausea | → | ||
| focus enhancement | ↑ | ||
| auditory effects | ↑ | ||
| sedation | → | ||
| closed-eye visuals | ↓ | ||
| open-eye visuals | → | ||
| muscle tension | — | → | |
| introspection | ↑ | ||
| hospital | — | → | |
| body high | — | → | |
| psychosis | — | → |
Showing top 20 of 23 effects
Risk Escalation
Sentiment AnalysisAverage frequency of positive vs adverse effects across dose tiers
View effect breakdown
Adverse Effects
| Effect | Strong (n=12) | Heavy (n=10) | Change |
|---|---|---|---|
| Anxiety | -55% | ||
| Confusion | +50% | ||
| Nausea | -4% | ||
| Muscle Tension | — | 0% | |
| Psychosis | — | 0% | |
| Memory Suppression | — | 0% |
Positive Effects
| Effect | Strong (n=12) | Heavy (n=10) | Change |
|---|---|---|---|
| Color Enhancement | -27% | ||
| Stimulation | 6% | ||
| Music Enhancement | 4% | ||
| Euphoria | -40% | ||
| Empathy | -65% | ||
| Tactile Enhancement | -52% | ||
| Focus Enhancement | +20% | ||
| Introspection | +19% | ||
| Body High | — | 0% |
Dosage Distribution
Dose distribution from experience reports
Real-World Dose Distribution
62K DosesFrom 62 individual dose entries
Oral (n=34)
Sublingual (n=9)
Common Combinations
Most co-occurring substances in experience reports
Form / Preparation
Most common forms and preparations reported
Body-Weight Dosing
Dose relative to body weight from reports with weight data
Oral
Sublingual
Redose Patterns
Redosing behavior across 43 reports
Legal Status
| Country | Status | Notes |
|---|---|---|
| Australia | Illegal | Prohibited under a blanket ban covering all substituted phenethylamines, which includes the entire DOx family of compounds. |
| Austria | Illegal | Controlled under the SMG (Suchtmittelgesetz Österreich). Possession, production, and sale are prohibited. |
| Belgium | Schedule I | Listed under HOOFDSTUK II of Belgian controlled substances legislation. Possession, distribution, and production are prohibited. |
| Brazil | Illegal | Listed on Portaria SVS/MS nº 344 under the name 'STP'. Possession, production, and sale are prohibited. |
| Canada | Schedule I | Controlled substance under the Controlled Drugs and Substances Act. Possession, trafficking, and production are criminal offenses. |
| Czech Republic | Schedule I | Classified as a Schedule I controlled substance under national drug legislation. |
| Germany | Anlage I BtMG | Controlled under Anlage I of the Betäubungsmittelgesetz (Narcotics Act) since April 15, 1971. Manufacturing, possession, import, export, buying, selling, procuring, or dispensing without a license is illegal. |
| Italy | Tabella I | Listed in Tabella I of the 'Tabelle delle sostanze stupefacenti e psicotrope'. Possession, purchase, and sale are illegal. |
| Latvia | Schedule I | Classified as a Schedule I controlled substance under Latvian drug control legislation. |
| New Zealand | Class A | Controlled as a Class A substance, the most restrictive classification under New Zealand's Misuse of Drugs Act. |
| Russia | Schedule I | Classified as a Schedule I substance in the Russian Federation. Buying, selling, or possessing without a license is illegal. |
| Switzerland | Verzeichnis D | Specifically named as a controlled substance under Verzeichnis D of Swiss narcotics legislation. |
| United Kingdom | Class A | Controlled under the Misuse of Drugs Act 1971. Buying, selling, or possessing without a license is prohibited. |
| United States | Schedule I | Controlled under the Controlled Substances Act. Manufacturing, buying, possessing, or distributing without a DEA license is illegal. |
Harm Reduction
drugs.wikiDOM has a slow onset and an extremely long duration; this historically led to non-fatal overdoses in the late 1960s when strong tablets were redosed prematurely. Redosing is discouraged, as intensity can increase significantly several hours after ingestion. Cardiovascular stimulation and peripheral vasoconstriction are commonly reported with DOx compounds; avoid combining with other stimulants or vasoconstrictors and avoid strenuous activity or hot environments; stay cool and sip fluids regularly. Lithium has repeatedly been associated with seizures and severe adverse reactions when combined with serotonergic psychedelics (e.g., LSD); by extension treat DOM + lithium as a dangerous combination. Metabolism involves CYP2D6; potent CYP2D6 inhibitors (fluoxetine, paroxetine, quinidine) may increase exposure, and DOM/related DOx can themselves inhibit CYP2D6—be cautious with co-medications that rely on this pathway. Immunoassay urine screens may return class-positive for ‘amphetamines’ with substituted amphetamines; targeted confirmation (e.g., GC/MS) can detect hydroxy-DOM and other metabolites, and detection windows vary—do not rely on specific ‘one week’ claims. Because DOM is potent at low milligram doses, use a 1 mg-accurate scale or volumetric dosing to reduce dosing error; avoid insufflation due to prolonged vasoconstriction and unpredictable intensity. Be prepared for insomnia during and after the experience; plan 24–36 hours of downtime. Where available, use reagent testing and consider lab drug checking; be aware that DOx has been sold on blotter or as other psychedelics—always wait at least 3 hours before making any dosing decisions.
References
Data Sources
Cited References
Drugs.wiki References
- TripSit DOM Wiki (dosage/duration, warning about long onset)
- Erowid DOM (STP) Vault (history of 1960s overdoses; long duration)
- PiHKAL #68 DOM (primary literature summary; human-active range)
- Ewald et al., 2007 (DOM metabolism via CYP2D6; hydroxy-DOM detection) — summary via Drugs-Forum studies and citation
- Bluelight discussion citing Ewald et al. J Chrom B 2007 (CYP2D6 involvement; analytical detection)
- Reddit r/researchchemicals: DOx and stimulant combo risks; vasoconstriction anecdotes (community harm-reduction context)
- Reddit r/researchchemicals: DOM dose-dependent body load and long stimulation (user report)
- Bluelight threads summarizing lithium + psychedelics seizure risk (applied cautiously to DOM)
- TripSit drug combination chart (general interaction cautioning for psychedelics + stimulants/MAOIs)
- Erowid Crew Blog/DrugsData project update (drug checking context; status updates 2024–2025)