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    Disclaimer
    ๐Ÿงช This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    DON Limited data
    Limited data
    Sparse data. Doses and effects may be unreliable or untested.
    • 2 corroborating sources
    • partial dose data
    • duration data present
    • 18 combo interactions documented
    • classified Tentative
    • classified Research-chemical

    Summary TripSit

    A very rare psychedelic Amphetamine. That is more rough on the body then other DOx compounds. Making it physically painful in some cases.

    Perspectives

    “There was an amphetamine-like stimulation that was apparent an hour into it, and considerable anxiety. I had stomach cramps, but there were indications that there might be something hallucinogenic at a higher dose.”

    Dose Information TripSit

    ROA Light Common Strong Heavy
    Oral 3mg 3-5mg - 5mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TripSit

    Effect Profile

    4 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 3.1
    Light+ 3/10

    Mild visuals with low body load and headspace

    Visual Intensity ×3
    4
    color enhancement brightened colour visual distortions
    Headspace Depth ×3
    2
    confusion time distortion
    Auditory Effects ×1
    0
    Body Load / Somatic Effects ×1
    3
    muscle tension increased heart rate

    Tolerance

    Build-up develops rapidly after a single use (serotonergic psychedelic)
    Reset 7โ€“14 days for baseline

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Effects TripSit

    Positive
    • Mental/physical stimulation
    • Stimulation
    Negative
    • Pupil dilation
    • Restlessness
    • Sweating/chills
    • Muscle tension
    • Insomnia
    • Increased heart rate
    Neutral
    • Decreased appetite
    • Sedation
    Positive
    • Euphoria
    • Empathy
    • Insight
    • Cognitive euphoria
    • Wakefulness
    Negative
    • Confusion
    • Anxiety
    Neutral
    • Change in perception
    • Ego softening
    • Time distortion
    Positive
    • Brightened colour
    • Enhanced tactile sensation
    • Color enhancement
    • Increased music appreciation
    Negative
    • Light sensitivity
    • Disinhibition
    • Appetite suppression
    Neutral
    • Closed/Open eye visuals
    • Visual distortions
    • Dulled perception

    Combinations TripSit

    Cross-Check DON with another substance

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.

    Erowid 3 reports 1 positive 1 neutral 1 cautionary visit
    The First Breakthrough positive exp #31010

    Setting: at home Dose: ~5.5mg Time: around midnight So, after a day of light drinking I came home and decided to try DON again. I had wanted to try this again since my previous attempt (with ~3.5mg) barely achieved what I would consider a +2 on the Shulgin scale.

    Michael · 5.5 mg oral / repeated smoked
    First Time Low-Dose Trial neutral exp #40414

    This was my first time with DON and purely a research endeavor, as there was little to no information provided about this compound. The entry in PiHkAL suggested that this be the more stimulating and less psychedelic version of DOB.

    Smoker · 2.5 mg oral / 1.0 mg oral / smoked / 1.0 mg oral
    Nauseous Hell Trip and Seizure cautionary exp #109798

    DON DOx Compound Near Death Experience I received a compound called DON through the deep web two years ago. I had received 2 tabs of it ['about 6mg']. I can't recall the time period but this was in the time period of 1-2 hours I placed the tab on my tongue and it was the nastiest substance I've put on my tongue for so...

    Eazy · 1.5 hits sublingual
    Bluelight 3 threads 1 positive 2 neutral visit
    Don Second Time First Breakthrough positive

    setting: at home dose: ~5.5mg time: around midnight so, after a day of light drinking i came home and decided to try DON again. i had wanted to try this again since my previous attempt (with ~3.5mg) barely achieved what i would consider a +2 on the shulgy scale.

    scraped 2026-03-14
    Don Experienced 3 5 Mgs neutral

    dosage: 3.5 mg's of the hydrochloride By some lucky chance i had become the lucky owner of quite an amount of DON(2,5-dimethoxy-4-nitro-amphetamine hydrochloride). It came as totally yellow crystals, which where quite soluble in alcohol and water.

    scraped 2026-03-14
    Don First Time Don A Trip Report neutral

    DON: A trip report I am sorry in advance if this is vague in any way, I am more of a Q&A type of person, if you have any specific questions, i am sure they are buried in my head and can be answered just yell! DON Trip report. Before dosing , I fasted for several hours (6) before ingesting this chem.

    scraped 2026-03-14

    Bluelight Reference Guide Bluelight

    The Big & Dandy DON Thread

    I didnt notice any don threads so i thought i would make one.Has anyone ever tried this one.I heard its actually better than dob and doi..I think it sounds really good and it only last 8-15 hours to

    Read full thread on Bluelight โ†’

    PiHKAL / TiHKAL Shulgin

    PiHKAL #70: DON

    “There was an amphetamine-like stimulation that was apparent an hour into it, and considerable anxiety. I had stomach cramps, but there were indications that there might be something hallucinogenic at a higher dose.”

    โ€” Alexander Shulgin, PiHKAL (with 3.0 mg)

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