Home
    Disclaimer
    ⚠ Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.
    ⚠ Deliriants can cause frightening, uncontrollable hallucinations and dangerous behavior. Medical emergencies are common at higher doses.

    Doxylamine

    Categories

    Depressant Deliriant Opioid
    Doxylamine structure

    Summary TripSit

    A first generation antihistamine and anticholinergic, originally used to treat nausea and itching, and later as a sleep aid. Causes drowsiness, and delirium in overdose. Sometimes used with opioids to combat nausea and potentiate effects.

    Dose Information TripSit

    ROA Light Common Strong Heavy
    Oral 75-200mg 200-350mg - 350mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TripSit

    ROA Onset Peak After Effects Total
    Oral 20-30 min 6.0-8.0 hrs 1.0-6.0 hrs 360-0 min

    Tolerance

    Build-up sedative effects diminish within 1–2 weeks of daily use
    Reset a few days of abstinence
    Cross-tolerance
    Diphenhydramine Hydroxyzine

    Effects

    Positive
    • Muscle relaxation
    Negative
    • Motor impairment
    • Dry mouth
    • Nausea
    • Increased heart rate
    • Muscle cramps
    • Pupil dilation
    Neutral
    • Sedation
    • Difficulty urinating
    • Hyperthermia
    Positive
    • Reduced anxiety
    Negative
    • Delirium
    • Anxiety
    • Confusion
    • Dizziness
    • Paranoia
    • Amnesia
    • Thought deceleration
    • Memory suppression
    Neutral
    • Time distortion
    Positive
    Negative
    • Photophobia
    • Acuity suppression
    • Visual acuity suppression
    Neutral
    • Dulled perception
    • Internal hallucinations
    • External hallucinations
    • Auditory hallucinations
    • Drifting
    • External hallucination
    • External Hallucination

    Combinations TripSit

    Helpful Links

    💊 Pill Identifier 📘 Experience Reports 📖 TripSit 📖 PsychonautWiki