At the time of writing, it is 12:57pm. Earlier today, at 11:35am, I administered a 10mg intranasal dose of Doxylamine succinate in order to assess the ability to incite a rapid onset sedation to counteract an anxiety attack. A 25mg oral dose was followed at 12:30pm.
Doxylamine
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 1 source
- partial dose data
- duration data present
- 19 combo interactions documented
- PubChem toxicity data
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 1 source
- partial dose data
- duration data present
- 19 combo interactions documented
- PubChem toxicity data
Summary
A first generation antihistamine and anticholinergic, originally used to treat nausea and itching, and later as a sleep aid. Causes drowsiness, and delirium in overdose. Sometimes used with opioids to combat nausea and potentiate effects.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 75-200mg | 200-350mg | - | 350mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Total |
|---|---|---|---|
| Oral | 20-30 min | 6-8 hrs | 6-8 hrs |
Effect Profile
6 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Opioid
1.4
Threshold
1/10
Mild sedation and itching/nausea
Euphoria / Warmth
×3
0
Analgesia
×2
0
Sedation / Relaxation
×1
5
sedation
muscle relaxation
Itching / Nausea
×1
5
nausea
dry mouth
Based on reports from:
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Name
Doxylamine
Unit
mg
Description
Doxylamine Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 10 · light 75-200 · common 200-350 · heavy 350+ Oral duration: onset 20-30m · peak 6-8h · total 6-8h · after-effects 1-6h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 275 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Build-up
sedative effects diminish within 1–2 weeks of daily use
Reset
a few days of abstinence
Tolerance Decay
Full tolerance
3d
Half tolerance
4d
Baseline
~5d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Cross-Tolerances
Diphenhydramine
30%
Hydroxyzine
30%
Effects
Aggregated from 6 Erowid experience reports
Positive Effects 2
Stimulation
66.7%
70%
Sedation
50.0%
70%
Adverse Effects 0
Combinations
Cross-Check Doxylamine with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 3 reports 3 cautionary visit
My experiences with doxylamine (Unisom) started when I was sent to San Jose for work. I get somewhat restless when I travel so I decided to buy this over the counter sleep-aid at the store.
Well this is about my 35th experience with Unisom Pills, but the worst of them all. I started taking them in about April and my first time i took 14, and I liked the trip so much I took them for about a month straight (everyday.) I got up to taking about a whole bottle a day (32 tablets: maximum strength) then I just d...
Bluelight 3 threads 3 neutral visit
Well I seen that Bluelight was in need for some doxylamine trip reports. And as I'm not one to dissapoint, I thought I'd give it a go. I read somewhere that a girl used to trip on this with about 14 caps. Being a male and over 100 kg, I took 20 caps.
So I had been researching for a while about this. I have Unisom and Benadryl for my insomnia. I'm a very depressed, lonely, psychotic human being. I'm autistic and bipolar. I'm a male and 140 lbs. Kinda wish I could use something else besides this stupid shit for both sleep and high.
t 0:36 i feel weird and drunk almost like dxm but this was doxylamine and i hear knocking t 1:00 i feel more tired and im kinda starting to see things like glitchieness and patterns and im also super paranoid and anxious that il see the scariest shit of my life t 2:00 still some glitchyness but im shaking so freaking h...
Pill Identifiers
1
known pill identifiers on record — view imprints, colors, shapes, and images
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Doxylamine's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
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