Doxylamine
Summary
A first generation antihistamine and anticholinergic, originally used to treat nausea and itching, and later as a sleep aid. Causes drowsiness, and delirium in overdose. Sometimes used with opioids to combat nausea and potentiate effects.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 75-200mg | 200-350mg | - | 350mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Total |
|---|---|---|---|
| Oral | 20-30 min | 6-8 hrs | 6.3-8.5 hrs |
Effect Profile
6 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Opioid
1.4
Threshold
1/10
Mild sedation and itching/nausea
Euphoria / Warmth
×3
0
Analgesia
×2
0
Sedation / Relaxation
×1
5
sedation
muscle relaxation
Itching / Nausea
×1
5
nausea
dry mouth
Based on reports from:
Tolerance
Build-up
sedative effects diminish within 1–2 weeks of daily use
Reset
a few days of abstinence
Tolerance Decay
Full tolerance
3d
Half tolerance
4d
Baseline
~5d
Cross-Tolerances
Diphenhydramine
30%
Hydroxyzine
30%
Effects
Aggregated from 6 Erowid experience reports
Positive Effects 2
Stimulation
66.7%
70%
Sedation
50.0%
70%
Adverse Effects 0
Combinations
Pill Identifiers
1
known pill identifiers on record — view imprints, colors, shapes, and images
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Doxylamine's nerd page
Pharmacology, chemical data, effect profiles, and more
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