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    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    DPP-26 Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 29 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: Db-900274, Dipipanone sulfone analogue

    Depressant Research-chemical Opioid

    Summary dose.wiki

    DPP-26 is the sulfone analogue of dipipanone, structurally related to IC-26 (methiodone, the sulfone analogue of methadone). Early user reports describe it as having faster onset and shorter duration than methadone, with notable euphoria. Vendor specifications and limited reports suggest approximately 0.4x morphine potency (roughly 25 mg DPP-26 equivalent to 10 mg morphine).

    Dose Information Drugs.Wiki

    Dose basis. The dose figures on this page are not clinical data. They are aggregated from community reports by a secondary source whose own notes state there is no human pharmacokinetic study behind them, and our internal audit flags this substance's dosing as unverifiable. Treat them as a rough orientation, not a safe range. Assume full respiratory depression, keep naloxone to hand, never dose alone, and never combine with benzodiazepines, alcohol or other depressants.

    ROA Light Common Strong Heavy
    Oral 5-15mg 15-35mg 35-60mg 60mg+
    Insufflated 3-10mg 10-25mg 25-45mg 45mg+
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — Drugs.Wiki

    Insufflated

    Dose ladder — Drugs.Wiki

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 20-45 min 30-60 min 1-3 hrs 4-6 hrs 12 hrs 5.83-10.75 hrs
    Insufflated 5-15 min 15-30 min 1-3 hrs 3-5 hrs 8 hrs 4.33-8.75 hrs

    Effect Profile

    Scores (0–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 6.3
    Strong 6/10

    Strong euphoria with moderate itching/nausea, mild sedation and pain relief

    Euphoria / Warmth ×3
    9
    physical euphoria cognitive euphoria euphoria
    Analgesia ×2
    4
    pain relief
    Sedation / Relaxation ×1
    5
    sedation muscle relaxation
    ⚠ Itching / Nausea ×1
    6
    nausea constipation
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset Falls quickly once you stop, at a rate you can't judge. After any break, treat your tolerance as gone.

    No tolerance chart. Our decay curves for opioids were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.

    Opioid tolerance drops fast when you stop, and even a few days off can be enough, so a dose that used to be normal can now stop your breathing. Overdose deaths rise sharply after prison, detox or leaving treatment, and tolerance also falls during a hospital stay. After any break, start with a much smaller amount, try a test dose first, don't use alone, and keep naloxone within reach. Alcohol, benzodiazepines, gabapentinoids and other sedatives make an opioid overdose much more likely.

    Sources: FRANK: heroin · National Harm Reduction Coalition · WHO: opioid overdose · Merrall et al. 2010 · Binswanger et al. 2007 · Strang et al. 2003 · FDA 2019: gabapentinoids and breathing

    Cross-Tolerances

    other µ‑opioid agonists

    Effects dose.wiki

    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral

    Combinations

    Cross-Check DPP-26 with another substance

    DPP-26's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📖 dose.wiki
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track DPP-26 there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "DPP-26 (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    DPP-26
    Unit
    mg
    Description 
    DPP-26
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 5 · light 5-15 · common 15-35 · strong 35-60 · heavy 60+
Insufflated dose (mg): threshold 3 · light 3-10 · common 10-25 · strong 25-45 · heavy 45+

Oral duration: onset 20-45m · come-up 0.5-1h · peak 1-3h · offset 4-6h · total 5.83-10.75h · after-effects 12h
Insufflated duration: onset 5-15m · come-up 15-30m · peak 1-3h · offset 3-5h · total 4.33-8.75h · after-effects 8h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 25 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.