DPP-26
Aliases: Db-900274, Dipipanone sulfone analogue
Summary
DPP-26 is the sulfone analogue of dipipanone, structurally related to IC-26 (methiodone, the sulfone analogue of methadone). Early user reports describe it as having faster onset and shorter duration than methadone, with notable euphoria. Vendor specifications and limited reports suggest approximately 0.4x morphine potency (roughly 25 mg DPP-26 equivalent to 10 mg morphine).
Dose Information
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset |
|---|---|---|---|---|
| Oral | 20-45 min | 30-60 min | 1-3 hrs | 4-6 hrs |
| Insufflated | 5-15 min | 15-30 min | 1-3 hrs | 3-5 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong euphoria with moderate itching/nausea, mild sedation and pain relief
Tolerance
Tolerance Decay
Patterns inferred from user accounts and general opioid pharmacology: daily use for a week commonly produces noticeable tolerance; partial decay occurs over 3–5 days; near‑baseline often requires 2–4 weeks. Cross‑tolerance with other opioids is expected.
Cross-Tolerances
Effects
- Physical euphoria
- Pain relief
- Muscle relaxation
- Stimulation
- Respiratory depression
- Nausea
- Increased heart rate
- Sedation
- Itchiness
- Pupil constriction
- Cognitive euphoria
- Anxiety suppression
- Reduced anxiety
- Euphoria
- Constipation
- Compulsive redosing
- Anxiety
- Thought deceleration
- Dizziness
- Time distortion
- Increased music appreciation
- Increased libido
- Tactile enhancement
- Color enhancement
- Disinhibition
- Light sensitivity
- Appetite suppression
- Dehydration
- Double vision
- Dulled perception