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    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    DPP-26 Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 1 source
    • 2 ROAs with full dose ladders
    • duration data present
    • 19 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: Db-900274, Dipipanone sulfone analogue

    Depressant Research-chemical Opioid

    Summary TheDrug.Wiki

    DPP-26 is the sulfone analogue of dipipanone, structurally related to IC-26 (methiodone, the sulfone analogue of methadone). Early user reports describe it as having faster onset and shorter duration than methadone, with notable euphoria. Vendor specifications and limited reports suggest approximately 0.4x morphine potency (roughly 25 mg DPP-26 equivalent to 10 mg morphine).

    Dose Information TheDrug.Wiki

    ROA Light Common Strong Heavy
    Oral 5-15mg 15-35mg 35-60mg 60mg+
    Insufflated 3-10mg 10-25mg 25-45mg 45mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Peak Offset After Effects Total
    Oral 20-45 min 1-3 hrs 4-6 hrs 12 hrs 6-10 hrs
    Insufflated - 1-3 hrs 4-6 hrs 12 hrs 6-10 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 6.3
    Strong 6/10

    Strong euphoria with moderate itching/nausea, mild sedation and pain relief

    Euphoria / Warmth ×3
    9
    physical euphoria cognitive euphoria euphoria
    Analgesia ×2
    4
    pain relief
    Sedation / Relaxation ×1
    5
    sedation muscle relaxation
    ⚠ Itching / Nausea ×1
    6
    nausea constipation
    Based on reports from:
    Erowid Experience Reports PsychonautWiki DPP-26
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 7d Half tolerance 7d Baseline ~35d

    Patterns inferred from user accounts and general opioid pharmacology: daily use for a week commonly produces noticeable tolerance; partial decay occurs over 3–5 days; near‑baseline often requires 2–4 weeks. Cross‑tolerance with other opioids is expected.

    Cross-Tolerances

    other µ‑opioid agonists
    100%

    Effects TheDrug.Wiki

    Positive
    • Physical euphoria
    • Pain relief
    • Muscle relaxation
    • Stimulation
    Negative
    • Respiratory depression
    • Nausea
    • Increased heart rate
    Neutral
    • Sedation
    • Itchiness
    • Pupil constriction
    Positive
    • Cognitive euphoria
    • Anxiety suppression
    • Reduced anxiety
    • Euphoria
    Negative
    • Constipation
    • Compulsive redosing
    • Anxiety
    • Thought deceleration
    • Dizziness
    Neutral
    • Time distortion
    Positive
    • Increased music appreciation
    • Increased libido
    • Tactile enhancement
    • Color enhancement
    Negative
    • Disinhibition
    • Light sensitivity
    • Appetite suppression
    • Dehydration
    • Double vision
    Neutral
    • Dulled perception

    Combinations TripSit

    Cross-Check DPP-26 with another substance

    DPP-26's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki