I had been becoming more and more interested in drugs of any and all kinds, and this curiosity surpassed the point of being satisfied by merely reading others experiences. I realized that I needed to know how it felt, to try everything.
Duloxetine
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 3 corroborating sources
- no dose data
- PubChem toxicity data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 3 corroborating sources
- no dose data
- PubChem toxicity data
Aliases: Cymbalta
Summary
Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder.
Effects
Aggregated from 15 Erowid experience reports
Positive Effects 5
Stimulation
33.3%
70%
Focus Enhancement
20.0%
70%
Euphoria
20.0%
70%
Body High
20.0%
70%
Empathy
20.0%
70%
Adverse Effects 3
Anxiety
60.0%
70%
Nausea
26.7%
70%
Confusion
20.0%
70%
Community Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 7 reports 6 neutral 1 cautionary visit
I am an 18 year old male. My father has clinical-depression and my mother is a narcissist. All my life I had thoughts of how much better it would be to go to sleep and not wake up. Think about a seven year old boy holding a steak knife thinking 'I want to kill myself'.
I'm on attempt #2 to get off Cymbalta and have had to go to a psychiatrist to help me get off it. Unfortunately his help in getting me off it hasn't worked yet either. What happens when I try to stop? Let's see.
I am a 59 yr old with chronic back pain. I have had a lumbar laminectomy and two spinal fusions (L4-L5-S1 ALIF + PLIF and L3-L4 XLIF) over the last four years. I take opiate pain medications, typically over the last year 20 to 40 mg Oxycontin and 10 to 30 mg Percocet daily.
Duloxetine first time I started taking Duloxetine for pain I have (fibromyalgia). At the first week starting dosage of 30mg/day it didn't seem to do a whole lot. But the first few days of the 60mg/day dosage felt like the aftereffects of an Ecstacy trip.
I started taking Cymbalta about a year and half ago. While at first I noticed a lot of improvement, I feel like it's working less and less. There's been very few negatives with Cymbalta. It makes me grind my teeth at night when I'm asleep, and it isn't the cheapest drug I've ever had, even with insurance.
Cymbalta Withdrawal Nightmares I have become increasingly aware (and disturbed by) the many cases of severe Cymbalta withdrawal symptoms. Including, but not limited to, 'brain zaps'! I myself have been on Cymbalta for eight years. I am terrified to go off of it because of the physical repercussions.
Bluelight 1 thread 1 cautionary visit
cymbalta (duloxitine) withdrawal - completely unbearable 3 days ago I stopped (forgot to take) my daily cymbalta 30 mg. I had successfully went from 60 to 30 mg. The first day, not much happened. I had skipped a dose so many times that the first day withdrawal no longer occurred.
Pill Identifiers
4
known pill identifiers on record — view imprints, colors, shapes, and images
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Duloxetine's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
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