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    Efavirenz Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 1 source
    • partial dose data
    • duration data present
    • 18 combo interactions documented
    • PubChem toxicity data

    Aliases: Sustiva

    Psychedelic

    Summary PsychonautWiki

    Efavirenz (sold by the brand name Sustiva) is an antiretroviral medication used in the treatment and prevention of HIV/AIDS. It is notable for being able to produce psychedelic and hallucinogenic effects despite possessing an extremely novel pharmacological profile and chemical structure not shared with any other psychedelic substance.

    Dose Information PsychonautWiki

    ROA Light Common Strong Heavy
    Smoked BA 50% - 600-1800mg - -
    Light Common Strong Heavy

    Onset, Duration & After-effects PsychonautWiki

    ROA Onset Peak After Effects
    Smoked 1-5 min 1-2 hrs 6-12 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 6.5
    Strong 6/10

    Strong visuals with mild headspace, auditory effects, and body load

    Visual Intensity ×3
    10
    color enhancement drifting tracers pattern recognition enhancement visual distortions brightened colour
    Headspace Depth ×3
    4
    introspection time distortion confusion
    Auditory Effects ×1
    4
    auditory distortion
    ⚠ Body Load / Somatic Effects ×1
    4
    nausea increased heart rate
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Efavirenz
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use (serotonergic psychedelic)
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Effects

    Positive
    • Stimulation
    • Mental/physical stimulation
    Negative
    • Nausea
    • Pupil dilation
    • Increased heart rate
    • Insomnia
    • Restlessness
    Neutral
    • Dilated pupils
    • Decreased appetite
    • Sedation
    Positive
    • Introspection
    • Euphoria
    • Wakefulness
    • Empathy
    • Insight
    • Analysis enhancement
    Negative
    • Anxiety
    • Confusion
    Neutral
    • Time distortion
    • Ego softening
    Positive
    • Color enhancement
    • Tracers
    • Increased music appreciation
    • Tactile enhancement
    • Enhanced tactile sensation
    • Pattern recognition enhancement
    • Brightened colour
    Neutral
    • Visual distortions
    • Drifting
    • Auditory distortion

    Combinations TripSit

    Cross-Check Efavirenz with another substance

    Pill Identifiers

    5 known pill identifiers on record — view imprints, colors, shapes, and images
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    Efavirenz's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    💊 Pill Identifier 📘 Experience Reports 📖 PsychonautWiki