Ephedrine - Substance Search

Summary TheDrug.Wiki Erowid TripSit PsychonautWiki

Ephedrine is a naturally occurring alkaloid found in Ephedra species. It is used medically as a bronchodilator, decongestant, and to treat hypotension. Structurally similar to amphetamines but less potent.

Dose Information TheDrug.Wiki TripSit PsychonautWiki

ROA	Light	Common	Strong	Heavy
Oral	10-20mg	20-30mg	30-50mg	50mg+

Light Common Strong Heavy

Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

ROA	Onset	Peak	Offset	After Effects	Total
Oral	20-90 min	1-2 hrs	2-4 hrs	2-4 hrs	3.3-7.5 hrs
Insufflated	5-15 min	30-60 min	1-2 hrs	2-4 hrs	1.6-3.2 hrs

Effect Profile

63 reports

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Validated against 63 Erowid trip reports
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Stimulant 7.8

Intense 8/10

Strong stimulation, euphoria, and anxiety/jitters with moderate focus

Stimulation / Energy ×3

10

stimulation wakefulness alertness enhancement

Euphoria / Mood Lift ×2

10

physical euphoria cognitive euphoria euphoria

Focus / Productivity ×2

6

memory enhancement

⚠ Anxiety / Jitters ×1

10

anxiety restlessness increased heart rate

Based on reports from:

Erowid Experience Reports PsychonautWiki Ephedrine

Tolerance

Build-up develops over days to weeks of regular use

Reset 3–7 days for acute; 1–3 weeks for full reset

Tolerance Decay

Full tolerance 2d Half tolerance 3d Baseline ~7d

Tachyphylaxis to pressor and subjective stimulant effects is common with repeated dosing over hours–days; substantial recovery generally occurs over several days of abstinence. Data are largely theoretical/anecdotal for recreational patterns.