Esketamine
Aliases: Spravato, Ketanest, Ketanest s
Summary
Ketamine (also known as Ket, K, Special K, vitamin K, Kitty, and others) is a classical dissociative substance of the arylcyclohexylamine class. It is perhaps the best-known and archetypal member of the dissociatives, a diverse group which includes PCP, methoxetamine, DXM, and nitrous oxide. The mechanism of action is not fully known, although blocking of the NMDA glutamate receptor is thought to be involved.
Dose Information
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset |
|---|---|---|---|---|
| Intranasal | 5-15 min | 5-15 min | 20-60 min | 1-2 hrs |
| Intravenous | 1-5 min | 2-5 min | 10-30 min | 45-90 min |
| Intramuscular | 2-10 min | 5-15 min | 30-60 min | 1-2 hrs |
Effect Profile
2 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong dissociative depth and motor impairment with mild mania and insight
Tolerance
Tolerance Decay
Rapid tolerance to subjective dissociation is commonly reported with repeated (daily or multi‑day) use and often partially decays over several days to weeks; estimates above are heuristic and based on community/HR summaries rather than controlled PK/PD studies.
Cross-Tolerances
Effects
- Pain relief
- Analgesia
- Stimulation
- Increased blood pressure
- Nausea
- Vertigo
- Insomnia
- Headache
- Sedation
- Physical disconnection
- Cognitive euphoria
- Conceptual thinking
- Immersion enhancement
- Depression reduction
- Depersonalization
- Derealization
- Motor control loss
- Memory suppression
- Cognitive disconnection
- Dizziness
- Anxiety
- Dissociation
- Time distortion
- Physical enhancement
- Spatial disorientation
- Derealization
- Light sensitivity
- Disinhibition
- Appetite suppression
- Visual distortions
- Visual disconnection
- Dulled perception
- Metallic taste