Ether Stats & Data
CCOCCRTZKZFJDLAIYFH-UHFFFAOYSA-NPharmacology
DrugBankMechanism of Action
The mechanism of action by which .... ethyl ether produce/s/ reversible loss of consciousness is still unclear. Anesthesia can be produced by a wide variety of chemical agents, ranging from inert rare gases to steriodal molecules. This apparent lack of specificity, together with the observation that general anesthesia can be reversed by high pressure, poses a unique pharmacological problem. Most theories concern interaction of anesthetics with either membrane lipids or hydrophobic regions of sp
Metabolism
It has been estimated that about 8-10% of absorbed ethyl ether is metabolized in the body whereas the remainder is excreted unchanged through the lungs. Ethyl ether is metabolized to ethanol and acetaldehyde by the inducible hepatic microsomal enzyme system, a cytochrome P450-containing monooxygenase system. Ethanol and acetaldehyde are rapidly oxidized to acetate, and the acetate subsequently enters the 2-carbon pool of intermediary metabolism.
This section covers risks general risks for both medical and nonmedical inhalants. For specific risks with nonmedical inhalants, see Toxicity and harm potential for toxic inhalants It is strongly recommended that one use harm reduction practices when using this class of substances. Both medical and nonmedical inhalants should be avoided by:
LD50
LD50: 996 mg/kg (Intravenous, Mouse) (L1327)LD50: 2420 mg/kg (Intraperitoneal, Mouse) (L1327)LD50: 1213 mg/kg (Oral, Rat) (A681)
Carcinogenicity
No indication of carcinogenicity to humans (not listed by IARC).
Addiction & dependence
The chronic use of many inhalants can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.
Effect Profile
Curated + 54 ReportsLow dissociative depth with strong mania, low motor impairment
Tolerance & Pharmacokinetics
drugs.wikiNo tolerance chart. Our decay curves for these drugs were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.
How fast tolerance to these drugs fades after a break has not been measured well enough to draw, so don't count on a dose you used to take still being safe: after time off, start with a much smaller amount and don't use alone. Mixing sedatives with each other, with alcohol or with opioids sharply raises the risk of a fatal overdose. If you've been using regularly, don't stop suddenly: withdrawal from benzodiazepines, alcohol or GHB/GBL can cause seizures or delirium, so get medical help to cut down gradually.
Sources: FRANK: benzodiazepines · Alcohol and Drug Foundation: GHB · FDA 2020: benzodiazepine boxed warning · FDA 2019: gabapentinoids and breathing · NHS: alcohol use disorder
Experience Report Analysis
ErowidDemographics
Gender Distribution
Age Distribution
Reports Over Time
Effect Analysis
ErowidEffects aggregated from 54 experience reports (54 single-substance Erowid)
Effect Sentiment Distribution
Confidence Distribution
Each bar is the share of reports mentioning the effect; its whisker, and the band on the rows below, is the 95% interval: where the share could plausibly be with other reports of the same kind.
Positive Effects 7
Adverse Effects 6
Show 5 neutral or unclassified mentions
Common Combinations
Most co-occurring substances, as a share of all 72 reports filed under Ether; whiskers are 95% intervals
Form / Preparation
Most common forms and preparations, as a share of the 44 reports that give one; whiskers are 95% intervals
Redose Patterns
Redosing behavior across 49 reports