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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    Flmodafinil

    Aliases: Nls-4, Lauflumide, Crl-40,940, Bisfluoromodafinil, crl-40-940

    Stimulant Nootropic Research-chemical

    Summary TheDrug.Wiki TripSit

    Flmodafinil (CRL-40,940; bisfluoromodafinil; lauflumide) is a bis(4-fluoro) derivative of modafinil with enhanced dopamine transporter affinity and improved lipophilicity. Unlike modafinil, it does not induce CYP3A4 or CYP3A5 enzymes, reducing drug-drug interactions. Animal studies demonstrate robust wake-promoting activity without classic amphetamine-like locomotor sensitisation.

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Oral / Sublingual 20-40mg 40-75mg 75-150mg 150mg+
    Oral 20-40mg 40-75mg 75-150mg 150mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Oral / Sublingual 20-40 min 30-60 min 2-4 hrs 2-4 hrs 6-6 hrs 4.8-9.7 hrs
    Insufflated 5-15 min 20-30 min 2-4 hrs 2-4 hrs 6-6 hrs 4.4-8.8 hrs
    Rectal (Solution) 15-30 min 30-60 min 2-4 hrs 2-4 hrs 6-6 hrs 4.8-9.5 hrs
    Oral 30-45 min - 6-12 hrs - 1-8 hrs 6.5-12.8 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 6.2
    Strong 6/10

    Strong focus and anxiety/jitters with moderate stimulation, mild euphoria

    Stimulation / Energy ×3
    7
    stimulation wakefulness enhancement wakefulness
    Euphoria / Mood Lift ×2
    5
    cognitive euphoria motivation enhancement
    Focus / Productivity ×2
    9
    focus enhancement analysis enhancement motivation enhancement thought acceleration
    ⚠ Anxiety / Jitters ×1
    9
    anxiety increased heart rate vasoconstriction sweating
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Flmodafinil
    View methodology →

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute tolerance; longer for full reset

    Effects TheDrug.Wiki

    Positive
    • Stimulation
    Negative
    • Increased heart rate
    • Vasoconstriction
    • Headaches
    • Nausea
    • Headache
    • Sweating
    • Diarrhea
    • Insomnia
    Neutral
    • Body odor alteration
    Positive
    • Wakefulness enhancement
    • Focus enhancement
    • Motivation enhancement
    • Analysis enhancement
    • Cognitive euphoria
    • Wakefulness
    Negative
    • Anxiety
    • Irritability
    • Dizziness
    Neutral
    • Thought acceleration
    Positive
    • Increased Music Appreciation
    • Increased music appreciation
    • Increased libido
    • Libido enhancement
    Negative
    • Appetite suppression
    • Dehydration
    • Light sensitivity
    • Photophobia
    • Appetite Suppression
    Neutral
    • Spontaneous physical sensations
    Flmodafinil's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 TripSit 📖 PsychonautWiki