Flmodafinil
Aliases: Nls-4, Lauflumide, Crl-40,940, Bisfluoromodafinil, crl-40-940
Categories
Summary
Flmodafinil (CRL-40,940; bisfluoromodafinil; lauflumide) is a bis(4-fluoro) derivative of modafinil with enhanced dopamine transporter affinity and improved lipophilicity. Unlike modafinil, it does not induce CYP3A4 or CYP3A5 enzymes, reducing drug-drug interactions. Animal studies demonstrate robust wake-promoting activity without classic amphetamine-like locomotor sensitisation. Human anecdotes report shorter subjective duration (6-8 hours) with crisper onset but potential late-phase anxiety spike 6-8 hours post-dose. Keeping daily use at or below 100 mg and finishing doses before 10 a.m.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral / Sublingual | 20-40mg | 40-75mg | 75-150mg | 150mg+ |
| Oral | 20-40mg | 40-75mg | 75-150mg | 150mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Oral / Sublingual | 20-40 min | 30-60 min | 2-4 hrs | 2-4 hrs | 6 hrs | 360-0 min |
| Insufflated | 5-15 min | 20-30 min | 2-4 hrs | 2-4 hrs | 6 hrs | 360-0 min |
| Rectal (Solution) | 15-30 min | 30-60 min | 2-4 hrs | 2-4 hrs | 6 hrs | 360-0 min |
| Oral | 30-45 min | - | 6.0-12.0 hrs | - | 1.0-8.0 hrs | 360-0 min |
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute tolerance; longer for full reset
Effects
Positive
- Stimulation
Negative
- Increased heart rate
- Vasoconstriction
- Headaches
- Nausea
- Headache
- Sweating
- Diarrhea
- Insomnia
- Body odor alteration
Positive
- Wakefulness enhancement
- Focus enhancement
- Motivation enhancement
- Analysis enhancement
- Cognitive euphoria
- Wakefulness
Negative
- Anxiety
- Irritability
- Dizziness
- Thought acceleration
Positive
- Increased Music Appreciation
- Increased music appreciation
- Increased libido
- Libido enhancement
Negative
- Appetite suppression
- Dehydration
- Light sensitivity
- Photophobia
- Appetite Suppression
- Spontaneous physical sensations