Flmodafinil
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- classified Tentative
- classified Research-chemical
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- classified Tentative
- classified Research-chemical
Aliases: Nls-4, Lauflumide, Crl-40,940, Bisfluoromodafinil, crl-40-940
Summary
Flmodafinil (CRL-40,940; bisfluoromodafinil; lauflumide) is a bis(4-fluoro) derivative of modafinil with enhanced dopamine transporter affinity and improved lipophilicity. Unlike modafinil, it does not induce CYP3A4 or CYP3A5 enzymes, reducing drug-drug interactions. Animal studies demonstrate robust wake-promoting activity without classic amphetamine-like locomotor sensitisation.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral / Sublingual | 20-40mg | 40-75mg | 75-150mg | 150mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral / Sublingual | 20-40 min | 30-60 min | 2-4 hrs | 2-4 hrs | 6-12 hrs |
| Insufflated | 5-15 min | 20-30 min | 2-4 hrs | 2-4 hrs | 6-12 hrs |
| Rectal (Solution) | 15-30 min | 30-60 min | 2-4 hrs | 2-4 hrs | 6-12 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong focus and anxiety/jitters with moderate stimulation, mild euphoria
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Flmodafinil there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Flmodafinil Source: SubstanceSearch (substancesearch.com) Oral / Sublingual dose (mg): threshold 15-20 · light 20-40 · common 40-75 · strong 75-150 · heavy 150+ Insufflated dose (mg): threshold 5 Rectal (Solution) dose (mg): threshold 10 Oral / Sublingual duration: onset 20-40m · come-up 0.5-1h · peak 2-4h · offset 2-4h · total 6-12h · after-effects 6h Insufflated duration: onset 5-15m · come-up 20-30m · peak 2-4h · offset 2-4h · total 6-12h · after-effects 6h Rectal (Solution) duration: onset 15-30m · come-up 0.5-1h · peak 2-4h · offset 2-4h · total 6-12h · after-effects 6h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 57.5 mg (Oral / Sublingual).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Anecdotal reports suggest noticeable attenuation after several consecutive days and substantial reduction after ~2 weeks of daily use; spacing 3–5 days between uses often preserves efficacy. Cross‑tolerance expected with other eugeroics (modafinil, armodafinil, adrafinil). Data quality: anecdotal.
Effects
- Stimulation
- Increased heart rate
- Vasoconstriction
- Headaches
- Nausea
- Headache
- Sweating
- Diarrhea
- Insomnia
- Body odor alteration
- Wakefulness enhancement
- Focus enhancement
- Motivation enhancement
- Analysis enhancement
- Cognitive euphoria
- Wakefulness
- Anxiety
- Irritability
- Dizziness
- Thought acceleration
- Increased Music Appreciation
- Increased libido
- Libido enhancement
- Appetite suppression
- Dehydration
- Light sensitivity
- Photophobia
- Spontaneous physical sensations
Helpful Links
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for Flmodafinil? Let us know. Reports are reviewed by moderators — this is not posted publicly.