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    Flubromazolam molecular structure

    Flubromazolam Stats & Data

    Depressant Research-chemical Benzodiazepine
    F-lam Jyi-73 Liquid xanax flam
    NPS DataHub
    MW371.21
    FormulaC17H12BrFN4
    CAS612526-40-6
    IUPAC8-bromo-6-(2-fluorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
    SMILESBrc1ccc2c(c1)C(=NCc1nnc(C)n12)c1ccccc1F
    InChIKeyVXGSZBZQCBNUIP-UHFFFAOYSA-N
    Benzodiazepines; 2020/3. Benzodiazepine; 2021/3. Benzodiazepine; 2022/3. Benzodiazepine
    Chemical Class Benzodiazepine
    Psychoactive Class Depressant

    Interaction Warnings

    ⚠ dissociatives

    This combination can result in an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If this occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it.

    ⚠ stimulants

    It is dangerous to combine benzodiazepines with stimulants due to the risk of excessive intoxication. Stimulants decrease the sedative effect of benzodiazepines, which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of benzodiazepines will be significantly increased, leading to intensified disinhibition as well as other effects.

    Receptor Profile

    Receptor Actions

    Modulators
    GABA-A receptor positive allosteric modulator (benzodiazepine site)

    History & Culture

    Flubromazolam, also designated JYI-73, is a novel synthetic triazolobenzodiazepine that emerged as part of the broader wave of designer benzodiazepines appearing on recreational drug markets. The substance first came to the attention of drug monitoring agencies following seizures by customs and law enforcement in Sweden, with the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) subsequently noting indications of its wider use as a recreational drug. Among designer benzodiazepines, flubromazolam has attracted particular concern from researchers and public health officials due to its exceptional potency, being active in the microgram range with an unusually prolonged duration of action. This pharmacological profile, combined with documented cases of life-threatening adverse reactions at doses as low as 3 milligrams, has led to warnings that flubromazolam and certain other potent triazolobenzodiazepines may pose substantially greater risks than many other substances in the designer benzodiazepine category.

    Subjective Effect Notes

    physical: The physical effects of flubromazolam can be broken down into several components which progressively intensify proportional to dosage.

    cognitive: The cognitive effects of flubromazolam can be broken down into several components which progressively intensify proportional to dosage. The general head space of flubromazolam is described by many as one of intense sedation and decreased inhibition. It contains a large number of typical depressant cognitive effects.

    Effect Profile

    Curated + 13 Reports
    Benzodiazepine 6.6

    Strong anxiolysis and cognitive impairment with moderate sedation, low euphoria

    Anxiolysis×3
    10
    Sedation / Relaxation×2
    6
    Motor / Cognitive Impairment×1
    8
    Euphoria / Mood Lift×1
    2
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Flubromazolam

    Tolerance & Pharmacokinetics

    drugs.wiki

    Tolerance Decay

    Full tolerance 3d Half tolerance 37d Baseline ~60d

    Cross-Tolerances

    Alprazolam
    85% ●○○
    Diazepam
    85% ●○○
    Clonazepam
    85% ●○○
    Lorazepam
    85% ●○○
    Etizolam
    85% ●○○
    Bromazolam
    85% ●○○
    Clonazolam
    85% ●○○
    Flualprazolam
    85% ●○○

    Experience Report Analysis

    Erowid
    13 Reports
    2015–2024 Date Range
    12 With Age Data
    11 Effects Detected

    Demographics

    Gender Distribution

    Age Distribution

    Reports Over Time

    Effect Analysis

    Erowid

    Effects aggregated from 13 experience reports (13 Erowid)

    13 Reports
    11 Effects Detected
    7 Positive
    3 Adverse
    1 Neutral

    Effect Sentiment Distribution

    Confidence Distribution

    Positive Effects 7

    Anxiety Suppression 61.5% 70%
    Sedation 46.2% 70%
    Euphoria 38.5% 70%
    Stimulation 38.5% 70%
    Color Enhancement 23.1% 70%
    Empathy 23.1% 70%
    Focus Enhancement 23.1% 70%

    Adverse Effects 3

    Memory Suppression 38.5% 70%
    Confusion 30.8% 70%
    Seizure 23.1% 70%

    Real-World Dose Distribution

    62K Doses

    From 12 individual dose entries

    Oral (n=7)

    Median: 0.25mg 25th: 0.25mg 75th: 0.5mg 90th: 0.6mg
    mg/kg median: 0.006 mg/kg 75th: 0.008

    Form / Preparation

    Most common forms and preparations reported

    Redose Patterns

    Redosing behavior across 11 reports

    0.0% Redosed
    1.0 Avg Doses

    Benzodiazepine Equivalence

    0.25 mg Flubromazolam = 10.0 mg Diazepam
    Potency ratio 40.0

    Flubromazolam - 0.25mg ~=10mg Diazepam.

    ⚠ All other CNS depressants.
    Read full reports on Erowid →

    Legal Status

    Country Status Notes
    Canada Schedule IV All benzodiazepines are controlled under Schedule IV of the Controlled Drugs and Substances Act.
    Germany NpSG (Neue-psychoaktive-Stoffe-Gesetz) Controlled under the New Psychoactive Substances Act since July 18, 2019. Production and import with intent to distribute, administration to another person, and trading are punishable offenses. Possession is technically illegal but not subject to criminal penalties.
    Netherlands List 2 (Opiumwet) Controlled under List 2 of the Opium Law (Opiumwet), making possession, distribution, and production illegal.
    Poland NPS controlled Classified as a New Psychoactive Substance (NPS) under Polish drug legislation, making both possession and distribution illegal.
    Russia Schedule III Listed as a Schedule III controlled substance since 2017 under Russian narcotics legislation.
    Switzerland Verzeichnis E Specifically named as a controlled substance under Verzeichnis E of the Swiss Narcotics Act (Betäubungsmittelgesetz).
    Turkey Illegal Classified as a controlled drug under Turkish law. Possession, production, supply, and import are all prohibited.
    United Kingdom Class C Designated as a Class C controlled substance under the Misuse of Drugs Act 1971 as of May 31, 2017. Possession, production, and supply carry criminal penalties.
    United States Schedule I Placed into Schedule I of the Controlled Substances Act as of January 23, 2023, indicating classification as having high abuse potential with no currently accepted medical use.

    References

    Data Sources

    Cited References

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