Summary
Fluorolintane exhibits high-affinity NMDA antagonism (Ki = 87.92 nM) with even stronger dopamine and norepinephrine transporter blockade, producing stimulant-euphoriant effects at light doses. ED50 for sensorimotor-gating disruption in rats is 13.3 mg/kg i.p. Subjective duration is shorter than diphenidine but more compulsive. Acute side effects include tachycardia, hypertension, nystagmus, and delayed urinary retention. No human pharmacokinetic data exists; rat microsome studies suggest elimination half-life of 4-8 hours with active hydroxylated metabolites.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral / Sublingual | 75-100mg | 100-150mg | 150-250mg | 250mg+ |
| Oral | 75-100mg | 100-150mg | 150-250mg | 250mg++ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Oral / Sublingual | 20-45 min | 30-60 min | 1-2 hrs | 2-3 hrs | 12 hrs | 180-0 min |
| Insufflated | 5-15 min | 15-30 min | 1-2 hrs | 2-3 hrs | 12 hrs | 180-0 min |
| Rectal | 10-20 min | 20-40 min | 1-2 hrs | 2-3 hrs | 12 hrs | 180-0 min |
| Oral | 15-45 min | - | 3.0-6.0 hrs | - | 2.0-6.0 hrs | 180-0 min |
Tolerance
Build-up
develops rapidly after a single use (serotonergic psychedelic)
Reset
7–14 days for baseline
Effects
Positive
- Stimulation
- Physical euphoria
- Pain relief
- Spontaneous tactile sensations
Negative
- Increased heart rate
- Numbness
- Loss of balance
- Clumsiness in movement
- Physical disconnection
- Tactile disconnection
Positive
- Euphoria
- Conceptual thinking
Negative
- Motor control loss
- Thought loops
- Confusion
- Depersonalization
- Derealization
- Anxiety
- Dissociation
- Time distortion
Positive
- Perception of bodily lightness
Negative
- Light sensitivity
- Tactile suppression
- Double vision
- Acuity suppression
- Auditory suppression
- Visual disconnection
- Internal hallucinations
- Auditory distortion
- Auditory hallucinations