Flutoprazepam Stats & Data
Clc1ccc2N(CC3CC3)C(=O)CN=C(c3ccccc3F)c2c1OFVXPDXXVSGEPX-UHFFFAOYSA-NReceptor Profile
Receptor Actions
Effect Profile
Curated + 1 ReportsStrong anxiolysis, euphoria, and cognitive impairment with mild sedation
Tolerance & Pharmacokinetics
drugs.wikiTolerance Decay
Benzodiazepine tolerance builds with frequent exposure (days–weeks) and decays slowly (weeks). Cross-tolerance exists across most GABA-A positive allosteric modulators. Figures are approximate and largely based on clinical practice patterns and community experience rather than controlled trials for this specific drug.
Cross-Tolerances
Experience Report Analysis
ErowidDemographics
Gender Distribution
Age Distribution
Reports Over Time
Benzodiazepine Equivalence
Flutoprazepam - ~2.5mg ~=10mg Diazepam.
Harm Reduction
drugs.wikiFlutoprazepam is a long-acting benzodiazepine; its primary active metabolite is norflurazepam (a.k.a. desalkylflurazepam), which has a long half-life and contributes to prolonged sedation and accumulation. This greatly increases next-day impairment and the risk that redosing will lead to blackouts. Driving or operating machinery can remain unsafe for 24–48+ hours after dosing, particularly with repeated use. Combining flutoprazepam with opioids, alcohol, GHB/GBL, or other depressants markedly raises overdose risk through additive/synergistic respiratory and CNS depression; naloxone will reverse opioid effects but not benzodiazepine sedation, so mixed overdoses may only be partially reversed. Long-acting benzodiazepines commonly appear in drug checking of the unregulated opioid supply (e.g., benzo-dope), which complicates overdose response and recovery; test your supply when possible and assume sedation may outlast the opioid. Tolerance to benzodiazepines can develop within days to weeks of regular use, while reversal of tolerance can take weeks; avoid daily use and space sessions by multiple days to reduce escalation. Abrupt cessation after frequent use can precipitate a dangerous withdrawal (including seizures); if dependent, taper gradually with medical supervision rather than stopping suddenly. Elderly individuals and those with pulmonary disease or sleep apnea are at increased risk of falls, confusion, and respiratory depression with long-acting benzodiazepines. Avoid using stimulants to counter sedation: this does not restore coordination/judgment and increases the likelihood of risky redosing. Because active duration is very long, single-dose trials should be small and well-spaced (e.g., at least 72 hours) before considering any redose. If using powders or liquids of uncertain strength, employ volumetric dosing to improve accuracy; in an unregulated market, consider drug checking services to verify identity and dose.
References
Data Sources
Cited References
- Barzaghi et al. 1989: Pharmacokinetics of flutoprazepam
- Bluelight: Flutoprazepam Discussion Thread
- DrugBank: Flutoprazepam
- Erowid Experience: Restas Regret
- PsychonautWiki: Benzodiazepines
- PsychonautWiki: Dangerous Combinations
- ScienceDirect: Flutoprazepam Overview
- Sukamoto et al. 1980: Psychopharmacological studies of KB-509
- TripSit Factsheet: Flutoprazepam
- TripSit Wiki: Benzodiazepines
- TripSit Wiki: Drug Combinations
- TripSit Wiki: Uncommon Benzodiazepines
- Bluelight: Flutoprazepam or Restas
- TripSit Factsheet: Norflurazepam
- TripSit Wiki: Benzodiazepines
- Drug-Do: Benzos
Drugs.wiki References
- Bluelight — Benzo discussion table listing flutoprazepam (Restas) dosing and 60–90 h duration
- Bluelight thread: Flutoprazepam/Restas (Japan-exclusive) user reports
- EUDA/EMCDDA drug profile: Benzodiazepines (class effects, durations, harms, overdose risks)
- IsomerDesign PiHKAL info: Norflurazepam synonyms include N‑desalkylflutoprazepam (metabolite link)
- PubChem: Desalkylflurazepam (Norflurazepam) CID 4540
- TripSit combinations: depressant mixing (alcohol/benzos) flagged dangerous
- DrugChecking.community (Toronto Drug Checking Service): frequent benzodiazepine co-detection with opioids; naloxone limits when benzos present
- NCBI Bookshelf: Concurrent benzo–opioid use linked to increased overdose risk (systematic evidence)
- NCBI CBHSQ/DAWN: ED outcomes worse with benzos plus alcohol/opioids
- Hi-Ground benzodiazepine harm-reduction page (unsafe combos; dependence/withdrawal warnings)