Summary
Flutoprazepam is an extremely long-acting benzodiazepine primarily used in Japan for severe insomnia and as an anticonvulsant. It is approximately 4 times more potent than diazepam by weight. The extremely long duration is due to its active metabolite norflurazepam (90 hour half-life), which causes significant accumulation and next-day sedation. Due to the long half-life, effects may not peak until many hours after administration. Has been reported as a date rape drug.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 0.5-1mg | 1.5-3mg | 3-5mg | 5mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | After Effects | Total |
|---|---|---|---|---|---|
| Oral | 30-90 min | 1-2 hrs | 2-12 hrs | 1440-0 min | 720-0 min |
Tolerance
Build-up
develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
Reset
weeks to months depending on half-life and duration of use; taper recommended
Effects
Positive
- Muscle relaxation
- Physical euphoria
- Anxiolytic
- Muscle Relaxant
Negative
- Respiratory depression
- Motor impairment
- Sedation
- Sedative
- Dystaxia
- Hypnotic
Positive
- Anxiety suppression
- Cognitive euphoria
Negative
- Motor control loss
- Amnesia
- Emotion suppression
- Delusions of sobriety
- Dream suppression
- Thought deceleration
- Dizziness
- Compulsive redosing
Positive
- Increased libido
- Appetite enhancement
Negative
- Disinhibition
- Acuity suppression
- Visual acuity suppression
- Decreased Libido
- Acuity Suppression
- Double vision
- Dulled perception
- Perception of bodily heaviness